MCL coexpression mm9:2853

Phase1 CAGE Peaks

	Short description
Mm9::chr13:49063373..49063398,-	p2@Fam120a
Mm9::chr13:49063403..49063437,-	p1@Fam120a
Mm9::chr6:119338689..119338757,-	p2@Adipor2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042562	hormone binding	0.00657426176518929
GO:0009755	hormone-mediated signaling	0.00657426176518929
GO:0009725	response to hormone stimulus	0.0082178272064866
GO:0019395	fatty acid oxidation	0.0082178272064866
GO:0046982	protein heterodimerization activity	0.0197227852955679
GO:0006631	fatty acid metabolic process	0.0388977154440366
GO:0042802	identical protein binding	0.0388977154440366
GO:0046983	protein dimerization activity	0.0388977154440366
GO:0032787	monocarboxylic acid metabolic process	0.0388977154440366
GO:0009719	response to endogenous stimulus	0.041089136032433

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	1.49e-18	118
endoderm	1.49e-18	118
presumptive endoderm	1.49e-18	118
digestive system	1.52e-17	116
digestive tract	1.52e-17	116
primitive gut	1.52e-17	116
subdivision of digestive tract	1.41e-16	114
gastrointestinal system	7.33e-15	47
intestine	4.48e-14	31
mucosa	3.51e-09	15
organ component layer	3.63e-09	24
gut epithelium	8.92e-09	55
exocrine gland	1.63e-08	25
exocrine system	1.63e-08	25
intestinal mucosa	2.89e-08	13
anatomical wall	2.89e-08	13
wall of intestine	2.89e-08	13
gastrointestinal system mucosa	2.89e-08	13
digestive tract diverticulum	3.99e-08	23
sac	3.99e-08	23
liver	1.06e-07	22
epithelial sac	1.06e-07	22
digestive gland	1.06e-07	22
epithelium of foregut-midgut junction	1.06e-07	22
anatomical boundary	1.06e-07	22
hepatobiliary system	1.06e-07	22
foregut-midgut junction	1.06e-07	22
hepatic diverticulum	1.06e-07	22
liver primordium	1.06e-07	22
septum transversum	1.06e-07	22
liver bud	1.06e-07	22
unilaminar epithelium	3.21e-07	66
trunk mesenchyme	3.78e-07	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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