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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.289355753601154,

Latest revision as of 12:13, 17 September 2013


Full id: C2823_mesenchymal_alveolar_spleen_Smooth_normal_mesodermal_Mesenchymal



Phase1 CAGE Peaks

Hg19::chr5:52083733..52083821,+p1@ITGA1
p2@PELO
Hg19::chr5:52083828..52083843,+p6@PELO
Hg19::chr5:52083850..52083861,+p9@PELO
Hg19::chr5:52083886..52083895,+p10@PELO


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0045123cellular extravasation0.0155415249616414
GO:0030593neutrophil chemotaxis0.0223346942055352
GO:0005518collagen binding0.0223346942055352
GO:0030595leukocyte chemotaxis0.0223346942055352
GO:0050900leukocyte migration0.0240797902081608
GO:0009897external side of plasma membrane0.0305050789062747
GO:0008305integrin complex0.0305050789062747
GO:0007229integrin-mediated signaling pathway0.038793191786861
GO:0007160cell-matrix adhesion0.038793191786861
GO:0031589cell-substrate adhesion0.038793191786861
GO:0043235receptor complex0.038793191786861
GO:0042330taxis0.0409869718598991
GO:0006935chemotaxis0.0409869718598991
GO:0009986cell surface0.0409869718598991
GO:0007626locomotory behavior0.0467614554761341



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
multi-tissue structure9.87e-11342
digestive system2.72e-10145
digestive tract2.72e-10145
primitive gut2.72e-10145
multi-cellular organism5.18e-10656
subdivision of digestive tract1.18e-09118
anatomical cluster1.47e-09373
endoderm-derived structure1.54e-08160
endoderm1.54e-08160
presumptive endoderm1.54e-08160
larynx4.16e-089
mesenchyme1.01e-07160
entire embryonic mesenchyme1.01e-07160
adult organism1.10e-07114
trunk mesenchyme1.54e-07122
organ system subdivision1.60e-07223
anatomical system2.19e-07624
anatomical group2.95e-07625
sac4.74e-0726
primordium7.55e-07160
Disease
Ontology termp-valuen
ovarian cancer4.77e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.11.6149
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.12.29123
MA0103.10.521546
MA0105.11.90157
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.12.95284
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.11.43218
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.70272
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.10559
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0021048
MA0102.21.75932
MA0258.11.07498
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335428.36945510360711.542446414682e-065.9007897839917e-05
CEBPB#105147.971147625824820.0002476385788090830.0026854039593232
CTCF#1066445.360256373075030.001211145381643620.00819347146738427
E2F1#186944.907389214879320.001724022357361790.0106749967973266
E2F6#187645.017155731697390.00157802193473060.00998769970555293
EBF1#187948.9064668465690.00015887907472010.0019994182051684
EP300#203346.77394172622320.0004748459821442640.00435059562498156
FOXA2#3170424.63046375266522.71504128667089e-069.45187323128735e-05
HNF4A#3172423.13229036295373.48990320893214e-060.000115782084255929
HNF4G#3174428.75342252644681.46167379934821e-065.67704536742759e-05
NFKB1#479045.488063424193840.001102199566301980.00769058127371808
POU2F2#545249.106124057742520.000145395665174930.00188680142584549
SP1#666745.69838137814090.0009482606065333980.00685508337272386
SRF#6722413.79717826216782.75840773062708e-050.000585301391667942
TAF1#687243.343046285745290.008005664898701650.0323144328807104
TFAP2C#7022410.80922860986027.32289634782688e-050.00114748082771297
YY1#752844.911170749853860.00171871838055440.0107017962765588
ZNF263#1012748.221841637010680.0002187871180958320.00249725768599023



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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