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|located_in=
|located_in=
|name=granulocyte monocyte progenitor cell
|name=granulocyte monocyte progenitor cell
|namespace=cell;;efo
|namespace=FANTOM
|obo_creation_date=
|obo_creation_date=
|part_of=UBERON:0002371
|part_of=UBERON:0002371

Latest revision as of 16:34, 12 September 2014

Name:granulocyte monocyte progenitor cell
Namespace:FANTOM
Definition:"A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251]
Synonyms: "CFU-C , Colony forming unit in culture" BROAD [1]
"CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
Comments:Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID: 19243617). GMPs are reportedly CD34-positive, CD38-positive, CD45RA-positive, and CD123-positive.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0000763(myeloid cell),CL:0001012(CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor),CL:1001610(bone marrow hematopoietic cell)
develops_from:CL:0000049(common myeloid progenitor)
part_of:UBERON:0002371(bone marrow)



Children


disjoint from:CL:0000049 (common myeloid progenitor),CL:0000050 (megakaryocyte-erythroid progenitor cell)
derives from:FF:0000070 (granulocyte macrophage progenitor cell sample)
develops from:CL:0000835 (myeloblast),CL:0002009 (macrophage dendritic cell progenitor),CL:0002028 (basophil mast progenitor cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

  • 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
  • 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
  • 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
  • 12131-128D7 (granulocyte macrophage progenitor, donor1)
  • 12135-128E2 (granulocyte macrophage progenitor, donor2)
  • 12139-128E6 (granulocyte macrophage progenitor, donor3)

Mouse (Mus musculus)

  • 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
  • 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
  • 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
  • 12131-128D7 (granulocyte macrophage progenitor, donor1)
  • 12135-128E2 (granulocyte macrophage progenitor, donor2)
  • 12139-128E6 (granulocyte macrophage progenitor, donor3)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000557 (granulocyte monocyte progenitor cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data