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{{Coexpression_clusters
{
|full_id=C3508_hepatoblastoma_non_neuroepithelioma_fibrous_Reticulocytes_myxofibrosarcoma_Fibroblast
 

Latest revision as of 12:27, 17 September 2013


Full id: C3508_hepatoblastoma_non_neuroepithelioma_fibrous_Reticulocytes_myxofibrosarcoma_Fibroblast



Phase1 CAGE Peaks

Hg19::chr15:69706617..69706641,+p3@KIF23
Hg19::chr1:68962744..68962772,-p1@DEPDC1
Hg19::chr1:68962782..68962801,-p3@DEPDC1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0051231spindle elongation0.00359113989022636
GO:0000022mitotic spindle elongation0.00359113989022636
GO:0007052mitotic spindle organization and biogenesis0.0131657686583527
GO:0007051spindle organization and biogenesis0.0170536462966801
GO:0005871kinesin complex0.020102687443671
GO:0005819spindle0.0466325961121085



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell5.16e-14253
animal cell1.85e-12679
eukaryotic cell1.85e-12679
embryonic cell6.49e-08250
migratory neural crest cell1.30e-0741
neurectodermal cell1.75e-0759
neuron associated cell5.31e-0717
neuron associated cell (sensu Vertebrata)5.31e-0717
neural cell6.58e-0725
Disease
Ontology termp-valuen
cancer4.65e-56235
disease of cellular proliferation7.45e-56239
cell type cancer6.46e-32143
organ system cancer3.02e-23137
carcinoma7.11e-21106
hematologic cancer2.85e-1451
immune system cancer2.85e-1451
leukemia1.15e-1139
myeloid leukemia1.37e-0931
germ cell and embryonal cancer1.53e-0822
germ cell cancer1.53e-0822
sarcoma1.18e-0720
disease of anatomical entity2.29e-0739


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.12.8588
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.668628
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.94723
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.20.09178
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467214.97544968400580.005768294540793880.0259524797977845
E2F1#186934.907389214879320.008460985347239390.0324587440743585
E2F4#1874312.66806031528440.0004917987006298980.00436425902753726
E2F6#187635.017155731697390.00791769806886330.0321432196460396
ELF1#199734.258097958807540.01295179875054610.0461253805397355
ETS1#211339.728760922202340.001085840092584840.00761049952549948
FOS#235338.99795530889440.001372499272417130.00896450603577064
MAX#414936.452555509007120.003721913834265510.0186227642857689
NFE2#4778251.4695071010860.0004987653528392110.00440586608180448
NFYA#4800318.42558069983050.0001598135507814160.00199292745433556
NFYB#4801316.75979325353650.0002123649923296180.00245426440565597
SETDB1#9869226.8800174520070.001814468907964410.0108921323300894
SIN3A#2594235.408884726815140.006318961977991520.0276058759315426
SP1#666735.69838137814090.005403962701712170.0246015631665628
TAF7#6879311.43306940492390.0006690181981945830.00541766237119052



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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