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Coexpression cluster:C1484: Difference between revisions

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{{Coexpression_clusters
{{Coexpression_clusters
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|full_id=C1484_Mesenchymal_MCF7_Smooth_Fibroblast_breast_Small_Corneal
|full_id=C1484_Mesenchymal_MCF7_Smooth_Fibroblast_breast_Small_Corneal
|id=C1484
|id=C1484

Revision as of 14:02, 12 September 2012


Full id: C1484_Mesenchymal_MCF7_Smooth_Fibroblast_breast_Small_Corneal



Phase1 CAGE Peaks

Hg19::chr20:62152108..62152136,+p1@PPDPF
Hg19::chr20:62153241..62153253,-p@chr20:62153241..62153253
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Hg19::chr20:62153268..62153299,-p@chr20:62153268..62153299
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Hg19::chr20:62153314..62153327,-p@chr20:62153314..62153327
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Hg19::chr20:62153354..62153376,-p@chr20:62153354..62153376
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Hg19::chr20:62153389..62153420,-p@chr20:62153389..62153420
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
epithelial cell4.49e-12254
non-terminally differentiated cell9.82e-10180
embryonic cell3.50e-09248
mesodermal cell8.96e-09119
contractile cell4.06e-0759
Uber Anatomy
Ontology termp-valuen
organism subdivision9.96e-10365
trunk1.68e-09216
multi-tissue structure2.51e-09347
trunk mesenchyme7.40e-09143
cell layer8.41e-09312
epithelium1.10e-08309
mesenchyme1.38e-08238
entire embryonic mesenchyme1.38e-08238
multilaminar epithelium1.33e-0782
multi-cellular organism2.51e-07659
unilaminar epithelium2.56e-07138
intermediate mesoderm6.78e-0737
muscle tissue9.22e-0763
musculature9.22e-0763
musculature of body9.22e-0763
urinary system structure9.65e-0744


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066454.466880310895860.001144848346172360.00783684973624532
ZBTB33#10009526.38727085831761.83222607625143e-071.00029199779207e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.