MCL coexpression mm9:1863

Phase1 CAGE Peaks

	Short description
Mm9::chr10:111434155..111434168,-	p3@Glipr1
Mm9::chr10:111434204..111434212,-	p5@Glipr1
Mm9::chr10:111434222..111434258,-	p1@Glipr1
Mm9::chr10:126727842..126727859,+	p1@Ddit3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042789	mRNA transcription from RNA polymerase II promoter	0.00421848463266313
GO:0009299	mRNA transcription	0.00421848463266313
GO:0030503	regulation of cell redox homeostasis	0.00562449209387472
GO:0006983	ER overload response	0.0126537204641331
GO:0030968	unfolded protein response	0.0202426245496088
GO:0033554	cellular response to stress	0.0210814447488924
GO:0006984	ER-nuclear signaling pathway	0.0210814447488924
GO:0051716	cellular response to stimulus	0.0210814447488924
GO:0006986	response to unfolded protein	0.0261331101426934
GO:0051789	response to protein stimulus	0.0261331101426934
GO:0045454	cell redox homeostasis	0.031600499200135
GO:0007050	cell cycle arrest	0.031600499200135

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
connective tissue cell	4.10e-11	46
mesenchymal cell	4.10e-11	46
hematopoietic cell	2.57e-10	32
hematopoietic oligopotent progenitor cell	2.57e-10	32
hematopoietic stem cell	2.57e-10	32
angioblastic mesenchymal cell	2.57e-10	32
hematopoietic multipotent progenitor cell	2.57e-10	32
motile cell	4.18e-09	54
hematopoietic lineage restricted progenitor cell	2.12e-07	25

Uber Anatomy

Ontology term	p-value	n
musculoskeletal system	1.63e-11	32
hemolymphoid system	2.72e-11	48
immune system	2.72e-11	48
connective tissue	4.10e-11	46
hematopoietic system	1.49e-10	45
blood island	1.49e-10	45
lateral plate mesoderm	3.17e-10	87
endoderm-derived structure	7.18e-09	118
endoderm	7.18e-09	118
presumptive endoderm	7.18e-09	118
digestive system	4.41e-08	116
digestive tract	4.41e-08	116
primitive gut	4.41e-08	116
subdivision of digestive tract	9.01e-08	114
mesoderm	1.74e-07	120
mesoderm-derived structure	1.74e-07	120
presumptive mesoderm	1.74e-07	120
bone marrow	2.72e-07	16
bone element	6.21e-07	22
skeletal element	6.21e-07	22
skeletal system	6.21e-07	22

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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