MCL coexpression mm9:282

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79605103..79605149,+	p1@Atp5d
Mm9::chr10:93661772..93661788,+	p1@Ndufa12
Mm9::chr11:4604306..4604333,-	p1@Gm6293 p1@Uqcr10
Mm9::chr11:4604337..4604354,-	p2@Gm6293 p2@Uqcr10
Mm9::chr12:103213893..103213956,-	p@chr12:103213893..103213956 -
Mm9::chr12:113205165..113205228,-	p1@2010107E04Rik
Mm9::chr15:35867911..35867933,-	p1@Cox6c p1@Gm6265
Mm9::chr15:82184655..82184691,-	p1@Ndufa6
Mm9::chr16:31948518..31948628,-	p1@0610012G03Rik
Mm9::chr16:91931799..91931863,-	p1@Atp5o p1@LOC100047429
Mm9::chr17:56857182..56857242,+	p1@Gm4943 p1@Ndufa11
Mm9::chr2:73749342..73749365,-	p1@Atp5g3
Mm9::chr4:115747627..115747654,-	p1@Uqcrh
Mm9::chr4:138686900..138686936,-	p1@Minos1
Mm9::chr5:108863378..108863389,-	p2@Atp5k
Mm9::chr5:108863392..108863428,-	p1@Atp5k
Mm9::chr5:145952403..145952417,-	p1@Atp5j2
Mm9::chr5:145952418..145952434,-	p2@Atp5j2
Mm9::chr5:145952435..145952441,-	p3@Atp5j2
Mm9::chr6:38484833..38484872,+	p1@1110001J03Rik
Mm9::chr6:39542568..39542587,+	p2@Ndufb2
Mm9::chr6:39542589..39542616,+	p1@Ndufb2
Mm9::chr7:104548559..104548625,+	p1@LOC635087 p1@LOC675851 p1@Ndufc2
Mm9::chr7:31411098..31411141,-	p1@Cox6b1
Mm9::chr7:31411146..31411158,-	p2@Cox6b1
Mm9::chr8:123192165..123192168,+	p3@Cox4i1
Mm9::chr8:123192181..123192199,+	p1@Cox4i1
Mm9::chr9:57369041..57369121,+	p1@Cox5a
Mm9::chr9:79607484..79607552,-	p1@Cox7a2
Mm9::chrX:103211038..103211098,+	p1@Cox7b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015078	hydrogen ion transmembrane transporter activity	1.05733629719142e-22
GO:0015077	monovalent inorganic cation transmembrane transporter activity	1.05733629719142e-22
GO:0022890	inorganic cation transmembrane transporter activity	3.54830758606969e-21
GO:0005739	mitochondrion	9.86692785967779e-19
GO:0006091	generation of precursor metabolites and energy	2.4288803476115e-15
GO:0008324	cation transmembrane transporter activity	7.5024477992368e-15
GO:0015075	ion transmembrane transporter activity	1.87677659765519e-13
GO:0004129	cytochrome-c oxidase activity	1.87677659765519e-13
GO:0016676	oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	1.87677659765519e-13
GO:0015002	heme-copper terminal oxidase activity	1.87677659765519e-13
GO:0016675	oxidoreductase activity, acting on heme group of donors	1.87677659765519e-13
GO:0022891	substrate-specific transmembrane transporter activity	8.03203548082412e-13
GO:0005743	mitochondrial inner membrane	1.79294810501441e-12
GO:0019866	organelle inner membrane	2.36125922112985e-12
GO:0031966	mitochondrial membrane	3.19913423151459e-12
GO:0022857	transmembrane transporter activity	3.45313822500132e-12
GO:0005740	mitochondrial envelope	5.69069868358036e-12
GO:0022892	substrate-specific transporter activity	9.04729830375329e-12
GO:0044429	mitochondrial part	2.24664088917973e-11
GO:0045259	proton-transporting ATP synthase complex	2.47998723586563e-11
GO:0044444	cytoplasmic part	4.04478104000245e-11
GO:0016491	oxidoreductase activity	4.14035824222607e-11
GO:0031975	envelope	8.25689641937836e-11
GO:0031967	organelle envelope	8.25689641937836e-11
GO:0005746	mitochondrial respiratory chain	2.26330566003301e-10
GO:0006754	ATP biosynthetic process	7.71766825778342e-10
GO:0006753	nucleoside phosphate metabolic process	7.71766825778342e-10
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	7.71766825778342e-10
GO:0006118	electron transport	8.05556299087337e-10
GO:0016469	proton-transporting two-sector ATPase complex	8.05556299087337e-10
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	8.05556299087337e-10
GO:0046034	ATP metabolic process	1.14142287713848e-09
GO:0031090	organelle membrane	1.14142287713848e-09
GO:0044455	mitochondrial membrane part	1.82288624436117e-09
GO:0009145	purine nucleoside triphosphate biosynthetic process	1.88343627958062e-09
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	1.88343627958062e-09
GO:0009201	ribonucleoside triphosphate biosynthetic process	1.88343627958062e-09
GO:0019829	cation-transporting ATPase activity	2.29993136824492e-09
GO:0009142	nucleoside triphosphate biosynthetic process	2.50016271453906e-09
GO:0009205	purine ribonucleoside triphosphate metabolic process	2.71317565922131e-09
GO:0009199	ribonucleoside triphosphate metabolic process	2.93949786269354e-09
GO:0006119	oxidative phosphorylation	3.10572142613345e-09
GO:0009144	purine nucleoside triphosphate metabolic process	3.10572142613345e-09
GO:0015992	proton transport	3.70374928605004e-09
GO:0006752	group transfer coenzyme metabolic process	3.98878846161067e-09
GO:0009141	nucleoside triphosphate metabolic process	4.70792313813386e-09
GO:0009152	purine ribonucleotide biosynthetic process	5.04803559962466e-09
GO:0006818	hydrogen transport	5.40620743321387e-09
GO:0009260	ribonucleotide biosynthetic process	6.86453453459934e-09
GO:0009150	purine ribonucleotide metabolic process	8.60754032332113e-09
GO:0006164	purine nucleotide biosynthetic process	9.13697633655863e-09
GO:0009259	ribonucleotide metabolic process	1.30947163954274e-08
GO:0006163	purine nucleotide metabolic process	1.70623179333128e-08
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	2.65334621531328e-08
GO:0009108	coenzyme biosynthetic process	2.94886131388546e-08
GO:0015985	energy coupled proton transport, down electrochemical gradient	4.44895075053608e-08
GO:0015986	ATP synthesis coupled proton transport	4.44895075053608e-08
GO:0051188	cofactor biosynthetic process	5.8450139263461e-08
GO:0005737	cytoplasm	8.7239609072799e-08
GO:0043492	ATPase activity, coupled to movement of substances	1.38094086905866e-07
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	1.38094086905866e-07
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.41908810414275e-07
GO:0009165	nucleotide biosynthetic process	1.79897586450396e-07
GO:0015399	primary active transmembrane transporter activity	2.21809094621284e-07
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	2.21809094621284e-07
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	3.48517249543282e-07
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3.48517249543282e-07
GO:0006732	coenzyme metabolic process	6.26132608600419e-07
GO:0009117	nucleotide metabolic process	1.17448947152925e-06
GO:0051186	cofactor metabolic process	1.3606977549702e-06
GO:0043231	intracellular membrane-bound organelle	1.43698032170725e-06
GO:0043227	membrane-bound organelle	1.44178994678713e-06
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	1.56499460731309e-06
GO:0042623	ATPase activity, coupled	3.20782411227553e-06
GO:0045277	respiratory chain complex IV	5.12142662743087e-06
GO:0005751	mitochondrial respiratory chain complex IV	5.12142662743087e-06
GO:0016887	ATPase activity	6.38709978841597e-06
GO:0015672	monovalent inorganic cation transport	9.85818446189381e-06
GO:0009055	electron carrier activity	1.3099532405824e-05
GO:0022804	active transmembrane transporter activity	1.53804529191378e-05
GO:0043229	intracellular organelle	1.56591431738442e-05
GO:0043226	organelle	1.56802140393725e-05
GO:0050136	NADH dehydrogenase (quinone) activity	1.85878917188007e-05
GO:0008137	NADH dehydrogenase (ubiquinone) activity	1.85878917188007e-05
GO:0003954	NADH dehydrogenase activity	1.85878917188007e-05
GO:0016655	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.22593648814792e-05
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	2.23327021135196e-05
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3.0893555504857e-05
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	5.29021266596043e-05
GO:0017111	nucleoside-triphosphatase activity	7.30249867802728e-05
GO:0006812	cation transport	8.28326688719e-05
GO:0016462	pyrophosphatase activity	9.07913750686655e-05
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	9.25249537390662e-05
GO:0016817	hydrolase activity, acting on acid anhydrides	9.25249537390662e-05
GO:0044446	intracellular organelle part	0.000118210290136629
GO:0044422	organelle part	0.000120296055700488
GO:0016020	membrane	0.000222191969850013
GO:0044424	intracellular part	0.000311841004108929
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	0.000357569312107896
GO:0016310	phosphorylation	0.000419934088670099
GO:0043234	protein complex	0.000462971162058658
GO:0006811	ion transport	0.000509175039586427
GO:0005622	intracellular	0.000510439505774936
GO:0006793	phosphorus metabolic process	0.000868157074691329
GO:0006796	phosphate metabolic process	0.000868157074691329
GO:0044249	cellular biosynthetic process	0.00119791353739778
GO:0032991	macromolecular complex	0.00179250151765528
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	0.00206099288275178
GO:0004450	isocitrate dehydrogenase (NADP+) activity	0.00403514912425858
GO:0006097	glyoxylate cycle	0.00403514912425858
GO:0009058	biosynthetic process	0.00440211700390514
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	0.00523506662048088
GO:0046487	glyoxylate metabolic process	0.00523506662048088
GO:0004448	isocitrate dehydrogenase activity	0.00906907335524909
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	0.0138616711060358
GO:0008121	ubiquinol-cytochrome-c reductase activity	0.0138616711060358
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	0.0138616711060358
GO:0006081	aldehyde metabolic process	0.0149871073464189
GO:0006810	transport	0.0175507520279265
GO:0042775	organelle ATP synthesis coupled electron transport	0.0183974721949875
GO:0044425	membrane part	0.0185690319330983
GO:0051234	establishment of localization	0.0194144269875745
GO:0042773	ATP synthesis coupled electron transport	0.0203241207026174
GO:0006099	tricarboxylic acid cycle	0.0283744543440641
GO:0046356	acetyl-CoA catabolic process	0.0293074506563158
GO:0009060	aerobic respiration	0.03022462737763
GO:0051179	localization	0.0326273468132348
GO:0009109	coenzyme catabolic process	0.0331418405798954
GO:0045333	cellular respiration	0.0340040252329686
GO:0051187	cofactor catabolic process	0.0359605109405213
GO:0006084	acetyl-CoA metabolic process	0.0378832626877978
GO:0016787	hydrolase activity	0.040075716893728

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	3.84e-09	18
heart	3.84e-09	18
primitive heart tube	3.84e-09	18
primary heart field	3.84e-09	18
anterior lateral plate mesoderm	3.84e-09	18
heart tube	3.84e-09	18
heart primordium	3.84e-09	18
cardiac mesoderm	3.84e-09	18
cardiogenic plate	3.84e-09	18
heart rudiment	3.84e-09	18
compound organ	3.86e-08	43
mucosa	5.00e-08	15
intestine	2.34e-07	31
intestinal mucosa	4.35e-07	13
anatomical wall	4.35e-07	13
wall of intestine	4.35e-07	13
gastrointestinal system mucosa	4.35e-07	13
cardiovascular system	6.25e-07	23
circulatory system	6.25e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}