MCL coexpression mm9:3087

Phase1 CAGE Peaks

	Short description
Mm9::chr17:27154937..27154948,+	p4@Ggnbp1
Mm9::chr3:40754701..40754760,+	p1@Larp1b
Mm9::chrX:48373220..48373254,-	p@chrX:48373220..48373254 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004221	ubiquitin thiolesterase activity	0.0394273087528991
GO:0004843	ubiquitin-specific protease activity	0.0394273087528991
GO:0019783	small conjugating protein-specific protease activity	0.0394273087528991
GO:0016790	thiolester hydrolase activity	0.0394273087528991
GO:0006511	ubiquitin-dependent protein catabolic process	0.0394273087528991
GO:0043632	modification-dependent macromolecule catabolic process	0.0394273087528991
GO:0019941	modification-dependent protein catabolic process	0.0394273087528991
GO:0051603	proteolysis involved in cellular protein catabolic process	0.0394273087528991
GO:0044257	cellular protein catabolic process	0.0394273087528991
GO:0008234	cysteine-type peptidase activity	0.0419109187530817
GO:0030163	protein catabolic process	0.0419109187530817
GO:0007283	spermatogenesis	0.0419109187530817
GO:0048232	male gamete generation	0.0419109187530817
GO:0044265	cellular macromolecule catabolic process	0.0430285432531639
GO:0043285	biopolymer catabolic process	0.0430285432531639
GO:0007276	gamete generation	0.0436572070344601
GO:0019953	sexual reproduction	0.0453258825033328
GO:0009057	macromolecule catabolic process	0.0453258825033328

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial tube	4.73e-12	47
exocrine gland	2.85e-08	25
exocrine system	2.85e-08	25
digestive tract diverticulum	9.08e-08	23
sac	9.08e-08	23
liver	2.33e-07	22
epithelial sac	2.33e-07	22
digestive gland	2.33e-07	22
epithelium of foregut-midgut junction	2.33e-07	22
anatomical boundary	2.33e-07	22
hepatobiliary system	2.33e-07	22
foregut-midgut junction	2.33e-07	22
hepatic diverticulum	2.33e-07	22
liver primordium	2.33e-07	22
septum transversum	2.33e-07	22
liver bud	2.33e-07	22
primary circulatory organ	3.97e-07	18
heart	3.97e-07	18
primitive heart tube	3.97e-07	18
primary heart field	3.97e-07	18
anterior lateral plate mesoderm	3.97e-07	18
heart tube	3.97e-07	18
heart primordium	3.97e-07	18
cardiac mesoderm	3.97e-07	18
cardiogenic plate	3.97e-07	18
heart rudiment	3.97e-07	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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