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{{Coexpression_clusters
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Latest revision as of 10:16, 17 September 2013


Full id: C45_testicular_choriocarcinoma_H9_teratocarcinoma_Wilms_pancreatic_iPS



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
4.38511719267935e-050.02775779182966037390{ASH2L,391} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
germ line cell3.15e-1127
germ cell3.15e-1127
Uber Anatomy
Ontology termp-valuen
testis2.26e-988
male reproductive organ6.65e-7211
gonad3.06e-3821
indifferent external genitalia3.06e-3821
indifferent gonad3.06e-3821
gonad primordium3.06e-3821
external genitalia1.49e-3622
male organism1.49e-3622
male reproductive system1.49e-3622
body cavity5.01e-1846
reproductive organ2.57e-1748
body cavity or lining5.55e-1749
body cavity precursor1.70e-1554
reproductive structure2.92e-1459
reproductive system2.92e-1459
anatomical cavity7.99e-1461
anatomical space3.52e-0995
immaterial anatomical entity1.34e-07117
Disease
Ontology termp-valuen
germ cell and embryonal cancer1.49e-3622
germ cell cancer1.49e-3622
carcinoma2.62e-08106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.17029e-10
MA0004.10.358892
MA0006.10.00481845
MA0007.10.341456
MA0009.10.477956
MA0014.17.08543e-08
MA0017.10.87206
MA0019.10.810009
MA0024.10.212877
MA0025.10.159093
MA0027.10.857047
MA0028.10.0010431
MA0029.10.0881203
MA0030.11.35043
MA0031.10.40772
MA0038.10.116506
MA0040.10.265689
MA0041.10.687179
MA0042.10.292811
MA0043.10.320091
MA0046.10.179483
MA0048.10.0260692
MA0050.10.000416672
MA0051.10.0134711
MA0052.10.0977314
MA0055.10.128693
MA0056.10
MA0057.10.711278
MA0058.10.224318
MA0059.10.0968152
MA0060.10.0132318
MA0061.10.0438007
MA0063.10
MA0066.12.48016
MA0067.10.442907
MA0068.10.388737
MA0069.10.0154563
MA0070.10.0377861
MA0071.11.09523
MA0072.10.151542
MA0073.19.44724e-07
MA0074.10.219162
MA0076.10.00527145
MA0077.10.529759
MA0078.11.20117
MA0081.10.0972073
MA0083.12.58024
MA0084.11.31668
MA0087.10.38206
MA0088.10.156993
MA0089.10
MA0090.10.0556292
MA0091.10.038077
MA0092.10.152559
MA0093.10.340227
MA0095.10
MA0098.10
MA0100.10.281318
MA0101.10.512635
MA0103.12.41896
MA0105.10.00330423
MA0106.12.02617
MA0107.10.276941
MA0108.20.539833
MA0109.10
MA0111.11.07251
MA0113.10.590693
MA0114.11.09831
MA0115.10.152031
MA0116.10.137519
MA0117.10.0730611
MA0119.10.00128544
MA0122.10.182518
MA0124.10.425147
MA0125.10.643266
MA0130.10
MA0131.10.0658899
MA0132.10
MA0133.10
MA0135.10.00717685
MA0136.10.0319894
MA0139.10.00112345
MA0140.10.0553599
MA0141.10.573972
MA0142.114.3987
MA0143.14.14773
MA0144.10.0602126
MA0145.10.581984
MA0146.10.487104
MA0147.10.0416386
MA0148.10.24519
MA0149.10.0453136
MA0062.20.00204084
MA0035.20.623909
MA0039.22.90453
MA0138.20.0129812
MA0002.20.331435
MA0137.20.143045
MA0104.20.00599956
MA0047.20.179558
MA0112.20.276083
MA0065.20.501908
MA0150.10.283754
MA0151.10
MA0152.10.550721
MA0153.10.234557
MA0154.13.4328
MA0155.10.165238
MA0156.10.0873919
MA0157.10.449138
MA0158.10
MA0159.10.793328
MA0160.10.604253
MA0161.10
MA0162.14.80093e-09
MA0163.10.073553
MA0164.10.996846
MA0080.20.00906307
MA0018.20.394422
MA0099.20.264637
MA0079.20.000399867
MA0102.20.273147
MA0258.11.29122
MA0259.10.196382
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POU5F1#54601310.71427424784964.89001376979414e-104.74635825375028e-08



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data