MCL coexpression mm9:993

Phase1 CAGE Peaks

	Short description
Mm9::chr3:30993616..30993634,+	p3@Skil
Mm9::chr3:87329494..87329565,+	p1@Etv3
Mm9::chr3:87329568..87329589,+	p2@Etv3
Mm9::chr4:155186603..155186638,+	p1@Ccnl2
Mm9::chr4:59202074..59202085,+	p3@Ugcg
Mm9::chr4:59202112..59202126,+	p2@Ugcg
Mm9::chr5:109058705..109058726,-	p2@Gak
Mm9::chr7:125386876..125386926,-	p2@Smg1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006679	glucosylceramide biosynthetic process	0.0183511363443851
GO:0046476	glycosylceramide biosynthetic process	0.0183511363443851
GO:0008120	ceramide glucosyltransferase activity	0.0183511363443851
GO:0006678	glucosylceramide metabolic process	0.0183511363443851
GO:0046513	ceramide biosynthetic process	0.0244574589523605
GO:0006688	glycosphingolipid biosynthetic process	0.0244574589523605
GO:0006677	glycosylceramide metabolic process	0.0244574589523605
GO:0035251	UDP-glucosyltransferase activity	0.0244574589523605
GO:0046520	sphingoid biosynthetic process	0.0244574589523605
GO:0046527	glucosyltransferase activity	0.0256775179255801
GO:0009247	glycolipid biosynthetic process	0.0266750174125593
GO:0017053	transcriptional repressor complex	0.0282077778601329
GO:0006687	glycosphingolipid metabolic process	0.0282077778601329
GO:0030148	sphingolipid biosynthetic process	0.0359484775696386
GO:0006664	glycolipid metabolic process	0.0359484775696386
GO:0043231	intracellular membrane-bound organelle	0.0359484775696386
GO:0043227	membrane-bound organelle	0.0359484775696386
GO:0006672	ceramide metabolic process	0.0467895503180661
GO:0046519	sphingoid metabolic process	0.0481709005625808

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	9.33e-17	118
endoderm	9.33e-17	118
presumptive endoderm	9.33e-17	118
digestive system	3.65e-16	116
digestive tract	3.65e-16	116
primitive gut	3.65e-16	116
subdivision of digestive tract	3.85e-15	114
gastrointestinal system	2.79e-10	47
intestine	2.03e-09	31
hemolymphoid system	2.90e-08	48
immune system	2.90e-08	48
mixed endoderm/mesoderm-derived structure	3.14e-08	35
organ component layer	1.55e-07	24
hematopoietic system	6.07e-07	45
blood island	6.07e-07	45
hemopoietic organ	8.75e-07	29
immune organ	8.75e-07	29
mucosa	9.13e-07	15

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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