Coexpression cluster:C1651

Full id: C1651_migratory_Burkitt_lymphoma_CD19_immature_epithelioid_Adipocyte

Phase1 CAGE Peaks

Hg19::chr11:9685714..9685715,+	p6@SWAP70
Hg19::chr11:9685717..9685723,+	p5@SWAP70
Hg19::chr11:9685724..9685742,+	p4@SWAP70
Hg19::chr11:9685751..9685772,+	p2@SWAP70
Hg19::chr11:9685775..9685791,+	p3@SWAP70

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	3.02e-12	24
lymphocyte of B lineage	7.52e-12	24
pro-B cell	7.52e-12	24
endothelial cell	1.24e-09	36
B cell	1.81e-09	14
stem cell	1.82e-09	441
multi fate stem cell	5.18e-09	427
somatic stem cell	8.72e-09	433
blood vessel endothelial cell	1.21e-08	18
embryonic blood vessel endothelial progenitor cell	1.21e-08	18
mesodermal cell	4.92e-08	121
somatic cell	1.51e-07	588
meso-epithelial cell	1.75e-07	45
endothelial cell of artery	3.34e-07	9

Uber Anatomy

Ontology term	p-value	n
vessel	5.79e-16	68
vasculature	4.36e-15	78
vascular system	4.36e-15	78
epithelial tube open at both ends	1.96e-14	59
blood vessel	1.96e-14	59
blood vasculature	1.96e-14	59
vascular cord	1.96e-14	59
artery	6.08e-13	42
arterial blood vessel	6.08e-13	42
arterial system	6.08e-13	42
splanchnic layer of lateral plate mesoderm	3.02e-11	83
cardiovascular system	3.31e-11	109
aorta	4.10e-11	21
aortic system	4.10e-11	21
circulatory system	8.89e-11	112
mesoderm	4.97e-09	315
mesoderm-derived structure	4.97e-09	315
presumptive mesoderm	4.97e-09	315
systemic artery	1.15e-08	33
systemic arterial system	1.15e-08	33
blood vessel endothelium	1.21e-08	18
endothelium	1.21e-08	18
cardiovascular system endothelium	1.21e-08	18
lateral plate mesoderm	1.57e-08	203
endothelial tube	3.34e-07	9
arterial system endothelium	3.34e-07	9
endothelium of artery	3.34e-07	9

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTCF#10664	5	5.36025637307503	0.000225927829993709	0.00249504881428708
E2F1#1869	5	4.90738921487932	0.000351281809925646	0.00352324219214679
EGR1#1958	5	4.98817909481014	0.000323739800059071	0.00330476600316385
FOXA1#3169	5	11.0814197493855	5.98116883436141e-06	0.000178782854004542
HEY1#23462	5	4.04011104310571	0.000928885220517799	0.00673646576943673
MAX#4149	5	6.45255550900712	8.93743970843928e-05	0.00130566130327275
NANOG#79923	5	29.2447784810127	4.66760911383881e-08	3.0391547895275e-06
NFKB1#4790	5	5.48806342419384	0.000200816284746232	0.00238791437579548
PAX5#5079	4	5.33565242494226	0.00222338958618779	0.0127734520596219
RAD21#5885	5	10.3550338954563	8.39503550283973e-06	0.00022928062575342
RFX5#5993	5	12.0479108271951	3.93714721313598e-06	0.000127382812203441
SMC3#9126	5	15.0449328449328	1.29633924985553e-06	5.15372572956459e-05
TAF1#6872	5	3.34304628574529	0.00239460009087031	0.0135176281763366
TBP#6908	5	3.70677068709639	0.00142875510672112	0.00917811259631242
TFAP2C#7022	3	6.48553716591613	0.00685895151794	0.0290534570726045
USF1#7391	5	6.36149927720796	9.59569864925045e-05	0.00136739687710338
USF2#7392	5	12.9921973850696	2.69963551658264e-06	9.41393100889397e-05

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.