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MCL coexpression mm9:1348

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Phase1 CAGE Peaks

 Short description
Mm9::chr13:52692230..52692280,+p1@Syk
Mm9::chr17:29497854..29497865,+p4@Fgd2
Mm9::chr17:29497868..29497885,+p1@Fgd2
Mm9::chr17:29497901..29497913,+p2@Fgd2
Mm9::chr5:135089861..135089869,+p@chr5:135089861..135089869
+
Mm9::chr6:29479277..29479296,+p2@Irf5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0046645positive regulation of gamma-delta T cell activation0.00918241562950581
GO:0045586regulation of gamma-delta T cell differentiation0.00918241562950581
GO:0045588positive regulation of gamma-delta T cell differentiation0.00918241562950581
GO:0046643regulation of gamma-delta T cell activation0.00918241562950581
GO:0043366beta selection0.00918241562950581
GO:0046629gamma-delta T cell activation0.00918241562950581
GO:0042492gamma-delta T cell differentiation0.00918241562950581
GO:0032632interleukin-3 production0.00918241562950581
GO:0045423regulation of granulocyte macrophage colony-stimulating factor biosynthetic process0.00918241562950581
GO:0042223interleukin-3 biosynthetic process0.00918241562950581
GO:0046638positive regulation of alpha-beta T cell differentiation0.00918241562950581
GO:0045399regulation of interleukin-3 biosynthetic process0.00918241562950581
GO:0032604granulocyte macrophage colony-stimulating factor production0.00918241562950581
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process0.00918241562950581
GO:0045401positive regulation of interleukin-3 biosynthetic process0.00918241562950581
GO:0042253granulocyte macrophage colony-stimulating factor biosynthetic process0.00918241562950581
GO:0043306positive regulation of mast cell degranulation0.00932765716338028
GO:0046637regulation of alpha-beta T cell differentiation0.00932765716338028
GO:0043304regulation of mast cell degranulation0.00932765716338028
GO:0001820serotonin secretion0.00932765716338028
GO:0043302positive regulation of leukocyte degranulation0.00932765716338028
GO:0004716receptor signaling protein tyrosine kinase activity0.0102015660325309
GO:0043300regulation of leukocyte degranulation0.0102015660325309
GO:0045579positive regulation of B cell differentiation0.0102015660325309
GO:0009966regulation of signal transduction0.0108810742005712
GO:0045921positive regulation of exocytosis0.0108810742005712
GO:0019815B cell receptor complex0.0108810742005712
GO:0050853B cell receptor signaling pathway0.0110559695686803
GO:0043303mast cell degranulation0.0110559695686803
GO:0002448mast cell mediated immunity0.0110559695686803
GO:0046641positive regulation of alpha-beta T cell proliferation0.0110559695686803
GO:0046635positive regulation of alpha-beta T cell activation0.0122398670223687
GO:0042101T cell receptor complex0.0125888876562747
GO:0046640regulation of alpha-beta T cell proliferation0.0125888876562747
GO:0045577regulation of B cell differentiation0.0125888876562747
GO:0043299leukocyte degranulation0.0132308385590431
GO:0007257activation of JNK activity0.0132308385590431
GO:0046634regulation of alpha-beta T cell activation0.013806810798841
GO:0043507positive regulation of JNK activity0.013806810798841
GO:0045576mast cell activation0.0139853536112926
GO:0045582positive regulation of T cell differentiation0.0139853536112926
GO:0046633alpha-beta T cell proliferation0.0139853536112926
GO:0050850positive regulation of calcium-mediated signaling0.0141399715230473
GO:0050848regulation of calcium-mediated signaling0.0141399715230473
GO:0019814immunoglobulin complex0.0141399715230473
GO:0045621positive regulation of lymphocyte differentiation0.0152939658847723
GO:0043506regulation of JNK activity0.0152939658847723
GO:0002444myeloid leukocyte mediated immunity0.0152939658847723
GO:0019370leukotriene biosynthetic process0.015660162802526
GO:0043450alkene biosynthetic process0.015660162802526
GO:0045058T cell selection0.0156962368925117
GO:0006691leukotriene metabolic process0.0156962368925117
GO:0045580regulation of T cell differentiation0.0156962368925117
GO:0043449alkene metabolic process0.0160143201507925
GO:0017157regulation of exocytosis0.0160143201507925
GO:0001772immunological synapse0.0174138406286009
GO:0019722calcium-mediated signaling0.0174138406286009
GO:0046632alpha-beta T cell differentiation0.0174138406286009
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation0.0174138406286009
GO:0045937positive regulation of phosphate metabolic process0.0176439705618541
GO:0042327positive regulation of phosphorylation0.0176439705618541
GO:0045619regulation of lymphocyte differentiation0.0181474588829467
GO:0046456icosanoid biosynthetic process0.0186348783617508
GO:0050871positive regulation of B cell activation0.0188647119334535
GO:0001934positive regulation of protein amino acid phosphorylation0.0188647119334535
GO:0002274myeloid leukocyte activation0.0188647119334535
GO:0033240positive regulation of amine metabolic process0.0188647119334535
GO:0045764positive regulation of amino acid metabolic process0.0188647119334535
GO:0050851antigen receptor-mediated signaling pathway0.0188647119334535
GO:0042102positive regulation of T cell proliferation0.0188647119334535
GO:0006690icosanoid metabolic process0.0206621704321326
GO:0046631alpha-beta T cell activation0.0207039760409873
GO:0050794regulation of cellular process0.0207039760409873
GO:0002429immune response-activating cell surface receptor signaling pathway0.0207039760409873
GO:0042108positive regulation of cytokine biosynthetic process0.0207039760409873
GO:0046777protein amino acid autophosphorylation0.0207039760409873
GO:0051050positive regulation of transport0.0207039760409873
GO:0050730regulation of peptidyl-tyrosine phosphorylation0.0207039760409873
GO:0002768immune response-regulating cell surface receptor signaling pathway0.0207039760409873
GO:0030183B cell differentiation0.0207039760409873
GO:0016540protein autoprocessing0.0207039760409873
GO:0000187activation of MAPK activity0.0207039760409873
GO:0032946positive regulation of mononuclear cell proliferation0.0207039760409873
GO:0002757immune response-activating signal transduction0.0207039760409873
GO:0050671positive regulation of lymphocyte proliferation0.0207039760409873
GO:0050864regulation of B cell activation0.0210305022186636
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0211068529752396
GO:0002764immune response-regulating signal transduction0.0211068529752396
GO:0045727positive regulation of translation0.0219656936642009
GO:0043406positive regulation of MAP kinase activity0.022118127185431
GO:0042129regulation of T cell proliferation0.022118127185431
GO:0050789regulation of biological process0.022118127185431
GO:0031328positive regulation of cellular biosynthetic process0.022118127185431
GO:0050870positive regulation of T cell activation0.022118127185431
GO:0007254JNK cascade0.022118127185431
GO:0031098stress-activated protein kinase signaling pathway0.0234109295651135
GO:0042035regulation of cytokine biosynthetic process0.0244154030996145
GO:0007242intracellular signaling cascade0.0244154030996145
GO:0033238regulation of amine metabolic process0.0244154030996145
GO:0001932regulation of protein amino acid phosphorylation0.0244154030996145
GO:0006521regulation of amino acid metabolic process0.0244154030996145
GO:0032944regulation of mononuclear cell proliferation0.0244154030996145
GO:0009891positive regulation of biosynthetic process0.0244154030996145
GO:0005089Rho guanyl-nucleotide exchange factor activity0.0244154030996145
GO:0050670regulation of lymphocyte proliferation0.0244154030996145
GO:0042098T cell proliferation0.0244154030996145
GO:0042325regulation of phosphorylation0.0244154030996145
GO:0051174regulation of phosphorus metabolic process0.0244154030996145
GO:0019220regulation of phosphate metabolic process0.0244154030996145
GO:0018212peptidyl-tyrosine modification0.0244154030996145
GO:0018108peptidyl-tyrosine phosphorylation0.0244154030996145
GO:0035023regulation of Rho protein signal transduction0.0244154030996145
GO:0065007biological regulation0.0247893561859587
GO:0005088Ras guanyl-nucleotide exchange factor activity0.0250240540445856
GO:0042089cytokine biosynthetic process0.0250240540445856
GO:0043405regulation of MAP kinase activity0.0250240540445856
GO:0042107cytokine metabolic process0.0250240540445856
GO:0051251positive regulation of lymphocyte activation0.0250240540445856
GO:0030217T cell differentiation0.0250240540445856
GO:0050863regulation of T cell activation0.0256263324847738
GO:0045055regulated secretory pathway0.0258165339542977
GO:0009967positive regulation of signal transduction0.0260035735278824
GO:0016485protein processing0.0261875283273319
GO:0006633fatty acid biosynthetic process0.0271526124222108
GO:0051247positive regulation of protein metabolic process0.0277130867422621
GO:0043235receptor complex0.0277685661527504
GO:0016053organic acid biosynthetic process0.0277685661527504
GO:0046394carboxylic acid biosynthetic process0.0277685661527504
GO:0032943mononuclear cell proliferation0.0277685661527504
GO:0046651lymphocyte proliferation0.0277685661527504
GO:0002253activation of immune response0.0286690324283054
GO:0007266Rho protein signal transduction0.0295554908748011
GO:0045860positive regulation of protein kinase activity0.0301621843115793
GO:0051249regulation of lymphocyte activation0.0301621843115793
GO:0051049regulation of transport0.0301621843115793
GO:0006887exocytosis0.0301621843115793
GO:0042113B cell activation0.0301621843115793
GO:0005057receptor signaling protein activity0.0301621843115793
GO:0050865regulation of cell activation0.0301621843115793
GO:0003001generation of a signal involved in cell-cell signaling0.0302932956542625
GO:0033674positive regulation of kinase activity0.0304225093778854
GO:0051347positive regulation of transferase activity0.0305498655750622
GO:0030098lymphocyte differentiation0.0313536373068666
GO:0018193peptidyl-amino acid modification0.0314726101525499
GO:0050778positive regulation of immune response0.032258489692224
GO:0002684positive regulation of immune system process0.0325868790417388
GO:0002443leukocyte mediated immunity0.0325868790417388
GO:0001816cytokine production0.0325868790417388
GO:0046578regulation of Ras protein signal transduction0.0326933318964655
GO:0050776regulation of immune response0.0360259074812326
GO:0002682regulation of immune system process0.0364281419128311
GO:0051240positive regulation of multicellular organismal process0.0374612634014225
GO:0042110T cell activation0.0375324467736921
GO:0000165MAPKKK cascade0.0376026710600474
GO:0005085guanyl-nucleotide exchange factor activity0.0379838020690934
GO:0019932second-messenger-mediated signaling0.0383599100753542
GO:0051056regulation of small GTPase mediated signal transduction0.0387310910747586
GO:0002521leukocyte differentiation0.0388515427925001
GO:0045859regulation of protein kinase activity0.0388515427925001
GO:0006417regulation of translation0.0398159959926496
GO:0043549regulation of kinase activity0.0398685531064233
GO:0043085positive regulation of catalytic activity0.0400221838720998
GO:0002252immune effector process0.0400221838720998
GO:0051338regulation of transferase activity0.0400221838720998
GO:0031326regulation of cellular biosynthetic process0.0409492830995674
GO:0007265Ras protein signal transduction0.0438971363101678
GO:0005083small GTPase regulator activity0.0439227612578624
GO:0009889regulation of biosynthetic process0.044808059020721
GO:0004713protein-tyrosine kinase activity0.0451127122921753
GO:0006631fatty acid metabolic process0.0456967656666056
GO:0045045secretory pathway0.0496382822950629
GO:0008284positive regulation of cell proliferation0.0496382822950629



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
common myeloid progenitor7.74e-0719

Uber Anatomy
Ontology termp-valuen
bone marrow5.10e-1116
bone element5.18e-1022
skeletal element5.18e-1022
skeletal system5.18e-1022
hemolymphoid system3.14e-0948
immune system3.14e-0948
hematopoietic system4.31e-0845
blood island4.31e-0845
musculoskeletal system5.60e-0732


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.476238
MA0004.10.536396
MA0006.10.359699
MA0007.10.52077
MA0009.10.987341
MA0014.10.0315641
MA0017.11.7816
MA0019.10.800946
MA0024.10.942716
MA0025.11.22395
MA0027.12.64231
MA0028.10.370592
MA0029.10.920529
MA0030.10.927235
MA0031.10.890871
MA0038.10.686534
MA0040.11.00009
MA0041.10.457338
MA0042.10.443591
MA0043.11.08567
MA0046.11.02391
MA0048.10.161427
MA0050.10.57678
MA0051.10.695779
MA0052.11.00829
MA0055.10.0585191
MA0056.10
MA0057.10.149949
MA0058.10.436487
MA0059.10.449345
MA0060.10.275911
MA0061.10.307097
MA0063.10
MA0066.10.675169
MA0067.11.33603
MA0068.10.467569
MA0069.11.00864
MA0070.10.998765
MA0071.11.41046
MA0072.10.990133
MA0073.16.00398
MA0074.10.638014
MA0076.10.407465
MA0077.10.968053
MA0078.10.729877
MA0081.11.19271
MA0083.11.08487
MA0084.11.66561
MA0087.11.04109
MA0088.10.725434
MA0089.10
MA0090.10.500693
MA0091.10.55008
MA0092.10.501022
MA0093.10.379257
MA0095.10
MA0098.10
MA0100.10.626021
MA0101.10.458688
MA0103.10.398766
MA0105.10.57901
MA0106.10.737893
MA0107.10.392331
MA0108.20.824407
MA0109.10
MA0111.10.515457
MA0113.10.708789
MA0114.10.304661
MA0115.12.46592
MA0116.10.944657
MA0117.11.05576
MA0119.10.459301
MA0122.11.07591
MA0124.11.28237
MA0125.11.20757
MA0130.10
MA0131.10.796279
MA0132.10
MA0133.10
MA0135.11.1226
MA0136.10.658622
MA0139.11.2655
MA0140.10.625902
MA0141.11.89066
MA0142.10.876028
MA0143.10.725672
MA0144.10.829535
MA0145.10.119202
MA0146.10.0392287
MA0147.10.320675
MA0148.10.553294
MA0149.10.464445
MA0062.20.591842
MA0035.20.630778
MA0039.20.328366
MA0138.20.788113
MA0002.20.689262
MA0137.20.416331
MA0104.20.261255
MA0047.20.685741
MA0112.20.119197
MA0065.23.16255
MA0150.10.520653
MA0151.10
MA0152.10.685852
MA0153.11.13945
MA0154.10.480757
MA0155.11.92909
MA0156.10.406559
MA0157.10.843181
MA0158.10
MA0159.10.331229
MA0160.10.556423
MA0161.10
MA0162.10.0465447
MA0163.10.372305
MA0164.11.58466
MA0080.21.01893
MA0018.20.669032
MA0099.20.781628
MA0079.20.31703
MA0102.21.7182
MA0258.10.290587
MA0259.10.309517
MA0442.10
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