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Coexpression cluster:C2223

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Full id: C2223_Neutrophils_Natural_Basophils_Peripheral_NK_CD8_CD14



Phase1 CAGE Peaks

Hg19::chr12:57872954..57872969,-p14@ARHGAP9
Hg19::chr16:11654835..11654841,+p@chr16:11654835..11654841
+
Hg19::chr16:11666245..11666255,-p@chr16:11666245..11666255
-
Hg19::chr16:81476783..81476798,+p@chr16:81476783..81476798
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>


Cell Type
Ontology termp-valuen
leukocyte8.37e-29136
CD8-positive, alpha-beta T cell1.96e-2611
hematopoietic stem cell5.15e-22168
angioblastic mesenchymal cell5.15e-22168
hematopoietic cell1.52e-20177
mature alpha-beta T cell1.18e-1918
alpha-beta T cell1.18e-1918
immature T cell1.18e-1918
mature T cell1.18e-1918
immature alpha-beta T cell1.18e-1918
hematopoietic oligopotent progenitor cell2.97e-18161
hematopoietic multipotent progenitor cell2.97e-18161
nongranular leukocyte2.17e-16115
natural killer cell4.85e-163
pro-NK cell4.85e-163
basophil9.66e-163
granulocyte1.33e-158
hematopoietic lineage restricted progenitor cell2.45e-15120
single nucleate cell2.55e-153
mononuclear cell2.55e-153
lymphoid lineage restricted progenitor cell6.16e-1552
lymphocyte1.35e-1453
common lymphoid progenitor1.35e-1453
nucleate cell5.91e-1455
T cell1.04e-1325
pro-T cell1.04e-1325
intermediate monocyte7.92e-139
CD14-positive, CD16-positive monocyte7.92e-139
blood cell2.90e-1111
myeloid leukocyte2.56e-0872
circulating cell7.00e-086
neutrophil1.07e-073
non-classical monocyte6.88e-073
CD14-low, CD16-positive monocyte6.88e-073
mesenchymal cell7.87e-07354


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.