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UBERON:0002532

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Name:epiblast
Definition:"In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]" [Wikipedia:Epiblast, ZFIN:curator]
Xrefs:
links:

BTO:0004593
MAT:0000067
MIAA:0000067

VHOG:0000243
Synonyms: "blastocyst" RELATED []
"ectoblast" RELATED [MP:0003886]
"primitive ectoderm" RELATED [VHOG:0000243]
Comments:MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class
Alt_id: UBERON:MIAA_0000067-ZFA_0000018
Subset: early_development
grouping_class
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0002050(embryonic structure)



Children

is a:UBERON:0008780 (inner cell mass derived epiblast)
develops from:UBERON:0000923 (germ layer),UBERON:0010316 (germ layer / neural crest)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology



Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002532 (epiblast), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
7.5e-31FFCP PHASE2:Hg19::chr20:23618584..23618603,-#_4e3ee18b06bf09a4cfc09653af000bd0p1@CST3
7.5e-31FFCP PHASE1:Hg19::chr20:23618584..23618603,-#_4e3ee18b06bf09a4cfc09653af000bd0p1@CST3
6.91e-29FFCP PHASE1:Hg19::chr13:77460532..77460548,-#_2b97e8c4198931b6e8e4ead92a5be977p1@KCTD12
6.91e-29FFCP PHASE2:Hg19::chr13:77460532..77460548,-#_2b97e8c4198931b6e8e4ead92a5be977p1@KCTD12
1.31e-28FFCP PHASE1:Hg19::chr13:45010939..45011033,-#_0972aa4510ed521af60abb12b7373a9cp1@TSC22D1
1.31e-28FFCP PHASE2:Hg19::chr13:45010939..45011033,-#_0972aa4510ed521af60abb12b7373a9cp1@TSC22D1
6.82e-28FFCP PHASE2:Hg19::chr2:230135937..230136016,-#_f80d1913823a2c6cc68101e71f8d79d9p1@PID1
6.82e-28FFCP PHASE1:Hg19::chr2:230135937..230136016,-#_f80d1913823a2c6cc68101e71f8d79d9p1@PID1
1.74e-26FFCP PHASE2:Hg19::chr7:111846435..111846471,-#_09186355d523945b6ed38c5e71965984p1@DOCK4
1.74e-26FFCP PHASE1:Hg19::chr7:111846435..111846471,-#_09186355d523945b6ed38c5e71965984p1@DOCK4
4.12e-26FFCP PHASE2:Hg19::chr11:1330834..1330875,-#_4056ab206f41590a6495e17e9354ac0ep1@TOLLIP
4.12e-26FFCP PHASE1:Hg19::chr11:1330834..1330875,-#_4056ab206f41590a6495e17e9354ac0ep1@TOLLIP
6.68e-25FFCP PHASE2:Hg19::chr12:112204714..112204781,+#_425caf8f5b84e56b61c9d64887e31111p1@ALDH2
6.68e-25FFCP PHASE1:Hg19::chr12:112204714..112204781,+#_425caf8f5b84e56b61c9d64887e31111p1@ALDH2
6.83e-25FFCP PHASE1:Hg19::chr13:77460594..77460613,-#_cd0f87def87d0ffc79918f23da26e253p3@KCTD12
6.83e-25FFCP PHASE2:Hg19::chr13:77460594..77460613,-#_cd0f87def87d0ffc79918f23da26e253p3@KCTD12
1.27e-24FFCP PHASE1:Hg19::chr4:85887789..85887862,-#_030041dd5a34be9d4927c80b94eaae89p1@WDFY3
1.27e-24FFCP PHASE2:Hg19::chr4:85887789..85887862,-#_030041dd5a34be9d4927c80b94eaae89p1@WDFY3
6.07e-24FFCP PHASE1:Hg19::chr16:4852616..4852679,-#_59e829c6b55b1e5a3fad88b725fba6f8p1@ROGDI
6.07e-24FFCP PHASE2:Hg19::chr16:4852616..4852679,-#_59e829c6b55b1e5a3fad88b725fba6f8p1@ROGDI
1.62e-23FFCP PHASE2:Hg19::chr1:183774240..183774270,+#_727ecc3909bfcadda08663f9140bdd6bp1@RGL1
1.62e-23FFCP PHASE1:Hg19::chr1:183774240..183774270,+#_727ecc3909bfcadda08663f9140bdd6bp1@RGL1
2.33e-23FFCP PHASE1:Hg19::chr8:30670289..30670354,-#_43d098d6a8c0d55612f2b9a4b5382b4cp1@PPP2CB
2.33e-23FFCP PHASE2:Hg19::chr8:30670289..30670354,-#_43d098d6a8c0d55612f2b9a4b5382b4cp1@PPP2CB
2.57e-23FFCP PHASE2:Hg19::chr13:77460635..77460654,-#_5bd8b19da60403995e1323e3de693f14p2@KCTD12
2.57e-23FFCP PHASE1:Hg19::chr13:77460635..77460654,-#_5bd8b19da60403995e1323e3de693f14p2@KCTD12
4.06e-23FFCP PHASE2:Hg19::chr4:159094160..159094185,-#_a9d557c2b6abe3917d422c9d1806ef09p2@FAM198B
4.06e-23FFCP PHASE1:Hg19::chr4:159094160..159094185,-#_a9d557c2b6abe3917d422c9d1806ef09p2@FAM198B
6.15e-23FFCP PHASE1:Hg19::chr15:90456156..90456198,-#_0cded6fba9152a11f68dbf9ea85c6df7p1@C15orf38
6.15e-23FFCP PHASE2:Hg19::chr15:90456156..90456198,-#_0cded6fba9152a11f68dbf9ea85c6df7p1@C15orf38
7.82e-23FFCP PHASE2:Hg19::chr19:40871734..40871809,+#_0338e5632c182e507611f8eb4a6b3216p1@PLD3
7.82e-23FFCP PHASE1:Hg19::chr19:40871734..40871809,+#_0338e5632c182e507611f8eb4a6b3216p1@PLD3
1.53e-22FFCP PHASE1:Hg19::chr16:2563989..2564006,+#_85d329fc99de046ad85445ae629d094dp2@ATP6V0C
1.53e-22FFCP PHASE2:Hg19::chr16:2563989..2564006,+#_85d329fc99de046ad85445ae629d094dp2@ATP6V0C
2.37e-22FFCP PHASE2:Hg19::chr20:35974484..35974529,+#_218bfca014d496e80bb51a109201ff94p2@SRC
2.37e-22FFCP PHASE1:Hg19::chr20:35974484..35974529,+#_218bfca014d496e80bb51a109201ff94p2@SRC
5.65e-22FFCP PHASE2:Hg19::chr11:65082349..65082378,+#_39f656c6ea7a1a64412b4c9b93ca1010p1@CDC42EP2
5.65e-22FFCP PHASE1:Hg19::chr11:65082349..65082378,+#_39f656c6ea7a1a64412b4c9b93ca1010p1@CDC42EP2
5.66e-22FFCP PHASE2:Hg19::chr17:1466030..1466129,-#_34bda6e8a79d961992346c843b384e1ep1@PITPNA
5.66e-22FFCP PHASE1:Hg19::chr17:1466030..1466129,-#_34bda6e8a79d961992346c843b384e1ep1@PITPNA
5.93e-22FFCP PHASE2:Hg19::chr19:6720653..6720670,-#_b174908955fdcc5de672116e93a7ee45p1@C3
5.93e-22FFCP PHASE1:Hg19::chr19:6720653..6720670,-#_b174908955fdcc5de672116e93a7ee45p1@C3
6.18e-22FFCP PHASE1:Hg19::chr7:2671611..2671658,+#_22b22779706208d2d583538b84526565p2@TTYH3
6.18e-22FFCP PHASE2:Hg19::chr7:2671611..2671658,+#_22b22779706208d2d583538b84526565p2@TTYH3
1.1e-21FFCP PHASE2:Hg19::chr2:127864839..127864888,-#_916eb9612dafd3a5fcce8b731724ecb7p2@BIN1
1.1e-21FFCP PHASE1:Hg19::chr2:127864839..127864888,-#_916eb9612dafd3a5fcce8b731724ecb7p2@BIN1
2.41e-21FFCP PHASE2:Hg19::chr17:73851380..73851427,-#_cfa959015e08db382b94704d7caa9fb0p1@WBP2
2.41e-21FFCP PHASE1:Hg19::chr17:73851380..73851427,-#_cfa959015e08db382b94704d7caa9fb0p1@WBP2
3.59e-21FFCP PHASE2:Hg19::chr22:31003154..31003188,+#_c05fa96e242e059b8f9dff2ebbd1972dp1@TCN2
3.59e-21FFCP PHASE1:Hg19::chr22:31003154..31003188,+#_c05fa96e242e059b8f9dff2ebbd1972dp1@TCN2
3.69e-21FFCP PHASE1:Hg19::chr9:14314566..14314618,-#_b3eeea4c6fb3385de558e2aa5b84a838p1@NFIB
3.69e-21FFCP PHASE2:Hg19::chr9:14314566..14314618,-#_b3eeea4c6fb3385de558e2aa5b84a838p1@NFIB
4.02e-21FFCP PHASE1:Hg19::chr9:14314131..14314147,-#_ae1fea3e6e5859faec6e79998c07ea32p2@NFIB
4.02e-21FFCP PHASE2:Hg19::chr9:14314131..14314147,-#_ae1fea3e6e5859faec6e79998c07ea32p2@NFIB
4.54e-21FFCP PHASE2:Hg19::chr19:44100155..44100211,-#_b37489456cb7b1f7056740a993726d13p1@IRGQ
4.54e-21FFCP PHASE1:Hg19::chr19:44100155..44100211,-#_b37489456cb7b1f7056740a993726d13p1@IRGQ
5.7e-21FFCP PHASE1:Hg19::chr4:24914581..24914691,-#_d307d1c9755a2ec8bd108a8b61f955a4p1@CCDC149
5.7e-21FFCP PHASE2:Hg19::chr4:24914581..24914691,-#_d307d1c9755a2ec8bd108a8b61f955a4p1@CCDC149
6.27e-21FFCP PHASE2:Hg19::chr2:127864608..127864688,-#_2386ff2dba52df2f4165c400d72e404cp1@BIN1
6.27e-21FFCP PHASE1:Hg19::chr2:127864608..127864688,-#_2386ff2dba52df2f4165c400d72e404cp1@BIN1
1.02e-20FFCP PHASE1:Hg19::chr19:14228541..14228582,-#_edc0a8183c6493f28d7daa057fce97dap1@PRKACA
1.02e-20FFCP PHASE2:Hg19::chr19:14228541..14228582,-#_edc0a8183c6493f28d7daa057fce97dap1@PRKACA
1.29e-20FFCP PHASE1:Hg19::chr16:89787269..89787359,-#_b529e790080c5abb79ee8a8d852ba877p1@C16orf7
1.29e-20FFCP PHASE2:Hg19::chr16:89787269..89787359,-#_b529e790080c5abb79ee8a8d852ba877p1@C16orf7
1.45e-20FFCP PHASE2:Hg19::chr1:10270620..10270637,+#_1d852043cf3a2191256be41478265a2cp1@KIF1B
1.45e-20FFCP PHASE1:Hg19::chr1:10270620..10270637,+#_1d852043cf3a2191256be41478265a2cp1@KIF1B
2.63e-20FFCP PHASE2:Hg19::chr18:59561635..59561651,-#_5b5c8761e74587d0362b6e71c9c80285p@chr18:59561635..59561651, -
2.63e-20FFCP PHASE1:Hg19::chr18:59561635..59561651,-#_5b5c8761e74587d0362b6e71c9c80285p@chr18:59561635..59561651, -
3.08e-20FFCP PHASE2:Hg19::chr12:52345448..52345532,+#_1ceaeb396aecd4e91a922fe63946f127p1@ACVR1B
3.08e-20FFCP PHASE1:Hg19::chr12:52345448..52345532,+#_1ceaeb396aecd4e91a922fe63946f127p1@ACVR1B
3.96e-20FFCP PHASE2:Hg19::chr20:23614485..23614564,-#_7a336af03d6701fcd85b51a2d631a41fp@chr20:23614485..23614564, -
3.96e-20FFCP PHASE1:Hg19::chr20:23614485..23614564,-#_7a336af03d6701fcd85b51a2d631a41fp@chr20:23614485..23614564, -
5.35e-20FFCP PHASE2:Hg19::chr1:68698197..68698214,-#_9d8c0844192b84df3332fee3dc2be3c2p1@WLS
5.35e-20FFCP PHASE1:Hg19::chr1:68698197..68698214,-#_9d8c0844192b84df3332fee3dc2be3c2p1@WLS
6.51e-20FFCP PHASE2:Hg19::chr10:30025922..30025958,-#_ad008731cba1f2eaf6ebd2380dcd977bp3@SVIL
6.51e-20FFCP PHASE1:Hg19::chr10:30025922..30025958,-#_ad008731cba1f2eaf6ebd2380dcd977bp3@SVIL
6.99e-20FFCP PHASE2:Hg19::chr15:64995399..64995422,-#_0d8491794eedbfd76e5c42e52716d9eep1@OAZ2
6.99e-20FFCP PHASE1:Hg19::chr15:64995399..64995422,-#_0d8491794eedbfd76e5c42e52716d9eep1@OAZ2
8.06e-20FFCP PHASE1:Hg19::chr9:34989685..34989748,+#_abe5a92c63500c16217dc45b79822b2dp1@DNAJB5
8.06e-20FFCP PHASE2:Hg19::chr9:34989685..34989748,+#_abe5a92c63500c16217dc45b79822b2dp1@DNAJB5
9.9e-20FFCP PHASE1:Hg19::chrX:100333858..100333876,+#_a76c4871575b9092a8e7287b32ae8aeap1@TMEM35
9.9e-20FFCP PHASE2:Hg19::chrX:100333858..100333876,+#_a76c4871575b9092a8e7287b32ae8aeap1@TMEM35
1.09e-19FFCP PHASE1:Hg19::chr16:2563941..2563983,+#_f58d1eca29e7639361c5ebc19d7c6845p1@ATP6V0C
1.09e-19FFCP PHASE2:Hg19::chr16:2563941..2563983,+#_f58d1eca29e7639361c5ebc19d7c6845p1@ATP6V0C
1.11e-19FFCP PHASE2:Hg19::chr17:68165657..68165688,+#_e761e14b2d4034657f80b9c3689568f1p1@KCNJ2
1.11e-19FFCP PHASE1:Hg19::chr17:68165657..68165688,+#_e761e14b2d4034657f80b9c3689568f1p1@KCNJ2
1.12e-19FFCP PHASE2:Hg19::chr17:7492684..7492778,-#_ab96814bfe67a7f4832dc2912085565cp2@SOX15
1.12e-19FFCP PHASE1:Hg19::chr17:7492684..7492778,-#_ab96814bfe67a7f4832dc2912085565cp2@SOX15
1.16e-19FFCP PHASE1:Hg19::chr19:11466086..11466159,+#_ef63dbed3e6fabceacadb2f19cc13459p1@LPPR2
1.16e-19FFCP PHASE2:Hg19::chr19:11466086..11466159,+#_ef63dbed3e6fabceacadb2f19cc13459p1@LPPR2
1.32e-19FFCP PHASE2:Hg19::chr18:59561658..59561685,-#_43631c3e3dfdef3d5a893779b22a8cc8p@chr18:59561658..59561685, -
1.32e-19FFCP PHASE1:Hg19::chr18:59561658..59561685,-#_43631c3e3dfdef3d5a893779b22a8cc8p@chr18:59561658..59561685, -
1.38e-19FFCP PHASE1:Hg19::chr12:110719036..110719113,+#_456c737cd8a5b1e3ac4cafbf2ae3b0d6p1@ATP2A2
1.38e-19FFCP PHASE2:Hg19::chr12:110719036..110719113,+#_456c737cd8a5b1e3ac4cafbf2ae3b0d6p1@ATP2A2
1.45e-19FFCP PHASE2:Hg19::chr6:123110389..123110441,+#_fb327e0bde48a1f24ec2f04cb6239f04p1@SMPDL3A
1.45e-19FFCP PHASE1:Hg19::chr6:123110389..123110441,+#_fb327e0bde48a1f24ec2f04cb6239f04p1@SMPDL3A
1.86e-19FFCP PHASE2:Hg19::chr10:118764649..118764683,-#_8d954ea905a5aca6543e4e97bd93018ap2@KIAA1598
1.86e-19FFCP PHASE1:Hg19::chr10:118764649..118764683,-#_8d954ea905a5aca6543e4e97bd93018ap2@KIAA1598
3.3e-19FFCP PHASE2:Hg19::chr2:153191678..153191697,+#_43996d591c7acbb5b45bd93e885f5966p1@FMNL2
3.3e-19FFCP PHASE1:Hg19::chr2:153191678..153191697,+#_43996d591c7acbb5b45bd93e885f5966p1@FMNL2

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