CL:0000557
From FANTOM5_SSTAR
Name: | granulocyte monocyte progenitor cell |
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Namespace: | cell;;efo |
Definition: | "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251] |
Synonyms: |
"CFU-C , Colony forming unit in culture" BROAD [1] "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] |
Comments: | Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID: 19243617). GMPs are reportedly CD34-positive, CD38-positive, CD45RA-positive, and CD123-positive. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | CL:0000763(myeloid cell),CL:0002032(hematopoietic oligopotent progenitor cell) |
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develops_from: | CL:0000049(common myeloid progenitor) |
part_of: | UBERON:0002371(bone marrow) |
Children
disjoint from: | CL:0000049 (common myeloid progenitor),CL:0000050 (megakaryocyte-erythroid progenitor cell) |
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derives from: | FF:0000070 (granulocyte macrophage progenitor cell sample) |
develops from: | CL:0000835 (myeloblast),CL:0002009 (macrophage dendritic cell progenitor),CL:0002028 (basophil mast progenitor cell) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
- 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
- 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
- 12131-128D7 (granulocyte macrophage progenitor, donor1)
- 12135-128E2 (granulocyte macrophage progenitor, donor2)
- 12139-128E6 (granulocyte macrophage progenitor, donor3)
Mouse (Mus musculus)
- 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
- 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
- 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
- 12131-128D7 (granulocyte macrophage progenitor, donor1)
- 12135-128E2 (granulocyte macrophage progenitor, donor2)
- 12139-128E6 (granulocyte macrophage progenitor, donor3)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000557 (granulocyte monocyte progenitor cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data