MCL coexpression mm9:1625

Phase1 CAGE Peaks

	Short description
Mm9::chr12:70825926..70825973,+	p1@Atp5s
Mm9::chr2:101469087..101469111,-	p3@B230118H07Rik
Mm9::chr2:101469115..101469171,-	p2@B230118H07Rik
Mm9::chr2:101469173..101469182,-	p4@B230118H07Rik
Mm9::chr2:101469183..101469191,-	p5@B230118H07Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	0.0115049580890812
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	0.0115049580890812
GO:0045259	proton-transporting ATP synthase complex	0.0115049580890812
GO:0016469	proton-transporting two-sector ATPase complex	0.0177368103873336
GO:0015992	proton transport	0.0185357658101865
GO:0006818	hydrogen transport	0.0185357658101865
GO:0015078	hydrogen ion transmembrane transporter activity	0.0230099161781625
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.0230099161781625
GO:0022890	inorganic cation transmembrane transporter activity	0.0279101761049934

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	5.47e-14	92
anatomical conduit	4.19e-08	122
primary circulatory organ	3.69e-07	18
heart	3.69e-07	18
primitive heart tube	3.69e-07	18
primary heart field	3.69e-07	18
anterior lateral plate mesoderm	3.69e-07	18
heart tube	3.69e-07	18
heart primordium	3.69e-07	18
cardiac mesoderm	3.69e-07	18
cardiogenic plate	3.69e-07	18
heart rudiment	3.69e-07	18
tube	5.97e-07	114
sense organ	7.64e-07	12
sensory system	7.64e-07	12
entire sense organ system	7.64e-07	12
cardiovascular system	8.89e-07	23
circulatory system	8.89e-07	23
compound organ	9.20e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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