MCL coexpression mm9:717

Phase1 CAGE Peaks

	Short description
Mm9::chr11:98216636..98216644,+	p@chr11:98216636..98216644 +
Mm9::chr11:98216649..98216660,+	p@chr11:98216649..98216660 +
Mm9::chr11:98216663..98216676,+	p@chr11:98216663..98216676 +
Mm9::chr12:115065398..115065415,-	p1@ENSMUST00000103457
Mm9::chr12:116610671..116610699,-	p@chr12:116610671..116610699 -
Mm9::chr19:21539679..21539681,-	p@chr19:21539679..21539681 -
Mm9::chr2:109740125..109740129,+	p@chr2:109740125..109740129 +
Mm9::chr6:78416298..78416310,-	p@chr6:78416298..78416310 -
Mm9::chr6:86715419..86715421,-	p@chr6:86715419..86715421 -
Mm9::chr7:52930395..52930401,+	p@chr7:52930395..52930401 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048521	negative regulation of behavior	0.00288529139880586
GO:0007621	negative regulation of female receptivity	0.00288529139880586
GO:0045924	regulation of female receptivity	0.00288529139880586
GO:0050795	regulation of behavior	0.00288529139880586
GO:0060181	female receptivity	0.00288529139880586
GO:0060180	female mating behavior	0.00288529139880586
GO:0004865	type 1 serine/threonine specific protein phosphatase inhibitor activity	0.0049459428233834
GO:0008599	protein phosphatase type 1 regulator activity	0.00540947675823292
GO:0033057	reproductive behavior in a multicellular organism	0.00673142443374804
GO:0007617	mating behavior	0.00778879287196149
GO:0007618	mating	0.0100952001073442
GO:0019098	reproductive behavior	0.0100952001073442
GO:0004864	protein phosphatase inhibitor activity	0.0106492977328508
GO:0019212	phosphatase inhibitor activity	0.0117417869620879
GO:0051705	behavioral interaction between organisms	0.0126883264074621
GO:0019888	protein phosphatase regulator activity	0.0172975207279368
GO:0019208	phosphatase regulator activity	0.0178048067250189
GO:0007269	neurotransmitter secretion	0.023657311898322
GO:0019717	synaptosome	0.023657311898322
GO:0045055	regulated secretory pathway	0.0266697990915955
GO:0005923	tight junction	0.0266697990915955
GO:0048609	reproductive process in a multicellular organism	0.0266697990915955
GO:0032504	multicellular organism reproduction	0.0266697990915955
GO:0006887	exocytosis	0.0277553794968213
GO:0003001	generation of a signal involved in cell-cell signaling	0.0277553794968213
GO:0043296	apical junction complex	0.0277553794968213
GO:0001505	regulation of neurotransmitter levels	0.0277553794968213
GO:0016327	apicolateral plasma membrane	0.0277553794968213
GO:0045211	postsynaptic membrane	0.0324387816027939
GO:0044456	synapse part	0.0347982125106223
GO:0005911	intercellular junction	0.0417134481758142
GO:0045045	secretory pathway	0.0471124669310346
GO:0007268	synaptic transmission	0.0492540285546446
GO:0032940	secretion by cell	0.0492540285546446
GO:0022414	reproductive process	0.0492540285546446
GO:0004857	enzyme inhibitor activity	0.0492540285546446

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
intestine	1.47e-18	31
mucosa	2.70e-17	15
gut-associated lymphoid tissue	3.12e-15	2
mucosa-associated lymphoid tissue	3.12e-15	2
lymphoid tissue	3.12e-15	2
gastrointestinal system	5.34e-12	47
organ component layer	9.67e-11	24
ileal mucosa	1.42e-10	3
ileum	1.42e-10	3
mucosa of small intestine	1.42e-10	3
wall of small intestine	1.42e-10	3
lymphoid system	1.77e-10	3
intestinal mucosa	2.21e-09	13
anatomical wall	2.21e-09	13
wall of intestine	2.21e-09	13
gastrointestinal system mucosa	2.21e-09	13
egg chamber	2.44e-08	1
small intestine	3.73e-08	4

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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