Coexpression cluster:C4767

Full id: C4767_NK_epithelioid_Burkitt_Natural_CD8_Basophils_Myoblast

Phase1 CAGE Peaks

Hg19::chr8:67525443..67525459,-	p2@MYBL1
Hg19::chr8:67525473..67525518,-	p1@MYBL1
Hg19::chr8:67525524..67525543,-	p3@MYBL1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
mature alpha-beta T cell	3.03e-09	18
alpha-beta T cell	3.03e-09	18
immature T cell	3.03e-09	18
mature T cell	3.03e-09	18
immature alpha-beta T cell	3.03e-09	18
T cell	1.36e-08	25
pro-T cell	1.36e-08	25
CD8-positive, alpha-beta T cell	1.96e-08	11

Disease

Ontology term	p-value	n
disease of cellular proliferation	1.22e-13	239
cancer	7.65e-13	235
cell type cancer	2.94e-11	143
carcinoma	2.90e-08	106

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BCLAF1#9774	3	21.6526476101218	9.8473954032885e-05	0.00139583622220962
BRCA1#672	3	20.1842306432238	0.000121570486027164	0.00164550284994699
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191332775440552
CHD2#1106	3	10.3440228341169	0.000903370110274688	0.00663108454786183
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0281520872643749
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.032798487442667
E2F4#1874	3	12.6680603152844	0.000491798700629898	0.00439262503165022
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0324611944968993
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322726129403264
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0465235738506718
ETS1#2113	3	9.72876092220234	0.00108584009258484	0.00765829642284358
GABPB1#2553	3	7.06768383618217	0.00283221282541742	0.015490624523371
HDAC2#3066	3	13.4156202366263	0.000414076139985721	0.00393858815883139
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.0109323722394301
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.0128809596612625
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0157751537643817
NRF1#4899	3	12.2102794477109	0.000549217240102001	0.00473812153799875
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0173753490825992
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0278470007181508
SIX5#147912	3	17.086715355459	0.000200406054632501	0.00240411301858072
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0248048371908811
SRF#6722	3	13.7971782621678	0.000380661502580019	0.00376726112650001
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0191297011739537
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0331422560972562
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0141052678756921
ZEB1#6935	3	16.8884320175439	0.000207548691732758	0.00243908831055221
ZNF143#7702	3	13.5008765522279	0.000406280496299717	0.00390641951326147

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.