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Coexpression cluster:C69

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Full id: C69_anaplastic_CD14_cord_hairy_mycosis_adult_NK



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0001525angiogenesis0.0299532388017022
GO:0048514blood vessel morphogenesis0.0299532388017022
GO:0048646anatomical structure formation0.0299532388017022
GO:0001568blood vessel development0.0299532388017022
GO:0003700transcription factor activity0.0299532388017022
GO:0001944vasculature development0.0299532388017022
GO:0045765regulation of angiogenesis0.0299532388017022
GO:0048513organ development0.0299532388017022
GO:00505763-keto-steroid reductase activity0.0299532388017022
GO:0043890N-acetylgalactosamine-6-sulfatase activity0.0299532388017022
GO:0022417protein maturation via protein folding0.0299532388017022
GO:0030852regulation of granulocyte differentiation0.0299532388017022
GO:0030854positive regulation of granulocyte differentiation0.0299532388017022
GO:0003806coagulation factor XIIa activity0.0299532388017022
GO:0005625soluble fraction0.0364471011885933
GO:0031404chloride ion binding0.0364471011885933
GO:0043168anion binding0.0364471011885933
GO:0003805coagulation factor XIa activity0.0364471011885933
GO:0015111iodide transmembrane transporter activity0.0364471011885933
GO:0005961glycine dehydrogenase complex (decarboxylating)0.0364471011885933
GO:0003943N-acetylgalactosamine-4-sulfatase activity0.0364471011885933
GO:0004375glycine dehydrogenase (decarboxylating) activity0.0364471011885933
GO:0016642oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor0.0364471011885933
GO:0005218intracellular ligand-gated calcium channel activity0.0483390129260326
GO:0042808neuronal Cdc2-like kinase binding0.0483390129260326
GO:0005219ryanodine-sensitive calcium-release channel activity0.0483390129260326



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>


Cell Type
Ontology termp-valuen
T cell2.15e-0925
pro-T cell2.15e-0925
Disease
Ontology termp-valuen
lymphoma3.81e-2110


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538191.800771338730620.01039111789574760.0385807516056022
STAT3#6774451.841929668762424.75053594801859e-050.00082621352851809



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data