MCL coexpression mm9:1977

Phase1 CAGE Peaks

	Short description
Mm9::chr11:61080576..61080588,-	p7@Aldh3a2
Mm9::chr11:61080589..61080603,-	p5@Aldh3a2
Mm9::chr11:61080604..61080636,-	p1@Aldh3a2
Mm9::chr1:90173839..90173869,-	p@chr1:90173839..90173869 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	0.00632772694899469
GO:0004029	aldehyde dehydrogenase (NAD) activity	0.00632772694899469
GO:0006081	aldehyde metabolic process	0.00723168794170821
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.0131074343943461
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0137402070892456

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	7.25e-20	118
endoderm	7.25e-20	118
presumptive endoderm	7.25e-20	118
digestive system	4.33e-19	116
digestive tract	4.33e-19	116
primitive gut	4.33e-19	116
subdivision of digestive tract	4.59e-18	114
unilaminar epithelium	1.24e-11	66
intestine	3.94e-11	31
trunk mesenchyme	6.64e-11	45
exocrine gland	1.88e-10	25
exocrine system	1.88e-10	25
gut epithelium	2.60e-10	55
digestive tract diverticulum	2.80e-10	23
sac	2.80e-10	23
liver	6.54e-10	22
epithelial sac	6.54e-10	22
digestive gland	6.54e-10	22
epithelium of foregut-midgut junction	6.54e-10	22
anatomical boundary	6.54e-10	22
hepatobiliary system	6.54e-10	22
foregut-midgut junction	6.54e-10	22
hepatic diverticulum	6.54e-10	22
liver primordium	6.54e-10	22
septum transversum	6.54e-10	22
liver bud	6.54e-10	22
gastrointestinal system	1.85e-09	47
endo-epithelium	2.16e-09	69
adult organism	3.28e-09	51
trunk	7.61e-08	90
mesenchyme	1.08e-07	61
entire embryonic mesenchyme	1.08e-07	61
mucosa	2.05e-07	15
foregut	4.92e-07	80

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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