Coexpression cluster:C3964
From FANTOM5_SSTAR
Full id: C3964_chronic_Mesenchymal_hepatocellular_hereditary_acute_rhabdomyosarcoma_Skeletal
Phase1 CAGE Peaks
| Hg19::chr1:28844730..28844776,+ | p2@RCC1 |
| Hg19::chr1:28844778..28844807,+ | p3@RCC1 |
| Hg19::chr22:20105012..20105085,+ | p1@RANBP1 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 4.59498110789263e-05 | 0.0290862304129603 | 2 | 194 | HIV Infection (Reactome):REACT_6185 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005083 | small GTPase regulator activity | 0.00884912319659774 |
| GO:0005087 | Ran guanyl-nucleotide exchange factor activity | 0.00884912319659774 |
| GO:0030695 | GTPase regulator activity | 0.00884912319659774 |
| GO:0007090 | regulation of S phase of mitotic cell cycle | 0.00884912319659774 |
| GO:0007052 | mitotic spindle organization and biogenesis | 0.00884912319659774 |
| GO:0008536 | Ran GTPase binding | 0.00884912319659774 |
| GO:0033261 | regulation of progression through S phase | 0.00904970673294687 |
| GO:0042393 | histone binding | 0.00904970673294687 |
| GO:0000084 | S phase of mitotic cell cycle | 0.00911647317396334 |
| GO:0007051 | spindle organization and biogenesis | 0.00916982948411652 |
| GO:0051320 | S phase | 0.00921343297182372 |
| GO:0000790 | nuclear chromatin | 0.00924972184269641 |
| GO:0005092 | GDP-dissociation inhibitor activity | 0.0102534655193447 |
| GO:0000794 | condensed nuclear chromosome | 0.0102534655193447 |
| GO:0007346 | regulation of progression through mitotic cell cycle | 0.0102534655193447 |
| GO:0000082 | G1/S transition of mitotic cell cycle | 0.0102534655193447 |
| GO:0000793 | condensed chromosome | 0.0147554015762654 |
| GO:0044454 | nuclear chromosome part | 0.0170067703933241 |
| GO:0007088 | regulation of mitosis | 0.0170067703933241 |
| GO:0017016 | Ras GTPase binding | 0.0185651040629841 |
| GO:0051329 | interphase of mitotic cell cycle | 0.018628663845914 |
| GO:0031267 | small GTPase binding | 0.018628663845914 |
| GO:0051325 | interphase | 0.0188654918799131 |
| GO:0051020 | GTPase binding | 0.0189105199641022 |
| GO:0000228 | nuclear chromosome | 0.0189105199641022 |
| GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0189105199641022 |
| GO:0003682 | chromatin binding | 0.0210616528993315 |
| GO:0016043 | cellular component organization and biogenesis | 0.0272424842678321 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.0274005387140235 |
| GO:0007067 | mitosis | 0.0368278486951195 |
| GO:0000087 | M phase of mitotic cell cycle | 0.0368278486951195 |
| GO:0051301 | cell division | 0.0368278486951195 |
| GO:0019899 | enzyme binding | 0.0412168034622221 |
| GO:0000279 | M phase | 0.0412168034622221 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 0.0412168034622221 |
| GO:0007017 | microtubule-based process | 0.0412168034622221 |
| GO:0000785 | chromatin | 0.0412168034622221 |
| GO:0000278 | mitotic cell cycle | 0.0412168034622221 |
| GO:0005096 | GTPase activator activity | 0.0420473751475497 |
| GO:0000074 | regulation of progression through cell cycle | 0.0420473751475497 |
| GO:0051726 | regulation of cell cycle | 0.0420473751475497 |
| GO:0022403 | cell cycle phase | 0.0421833541290076 |
| GO:0008047 | enzyme activator activity | 0.0494377287556743 |
| GO:0006323 | DNA packaging | 0.0494377287556743 |
| GO:0044427 | chromosomal part | 0.0494377287556743 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| animal cell | 1.74e-27 | 679 |
| eukaryotic cell | 1.74e-27 | 679 |
| epithelial cell | 8.27e-26 | 253 |
| native cell | 1.37e-16 | 722 |
| embryonic cell | 6.05e-15 | 250 |
| squamous epithelial cell | 6.34e-08 | 63 |
| kidney cell | 1.84e-07 | 17 |
| kidney epithelial cell | 1.84e-07 | 17 |
| epithelial cell of nephron | 2.07e-07 | 15 |
| somatic cell | 3.27e-07 | 588 |
| Ontology term | p-value | n |
|---|---|---|
| nephron epithelium | 2.07e-07 | 15 |
| renal tubule | 2.07e-07 | 15 |
| nephron tubule | 2.07e-07 | 15 |
| nephron | 2.07e-07 | 15 |
| uriniferous tubule | 2.07e-07 | 15 |
| nephrogenic mesenchyme | 2.07e-07 | 15 |
| segment of respiratory tract | 5.58e-07 | 47 |
| larynx | 6.22e-07 | 9 |
| Ontology term | p-value | n |
|---|---|---|
| cancer | 9.68e-34 | 235 |
| disease of cellular proliferation | 2.83e-32 | 239 |
| hematologic cancer | 8.99e-18 | 51 |
| immune system cancer | 8.99e-18 | 51 |
| organ system cancer | 1.20e-17 | 137 |
| cell type cancer | 1.37e-16 | 143 |
| carcinoma | 1.88e-16 | 106 |
| leukemia | 5.91e-15 | 39 |
| myeloid leukemia | 3.49e-12 | 31 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 3.22681 |
| MA0004.1 | 1.93041 |
| MA0006.1 | 0.639288 |
| MA0007.1 | 0.804807 |
| MA0009.1 | 1.3275 |
| MA0014.1 | 0.377374 |
| MA0017.1 | 0.686276 |
| MA0019.1 | 0.990656 |
| MA0024.1 | 1.21731 |
| MA0025.1 | 1.46617 |
| MA0027.1 | 2.95767 |
| MA0028.1 | 0.658629 |
| MA0029.1 | 1.23771 |
| MA0030.1 | 1.22561 |
| MA0031.1 | 1.15713 |
| MA0038.1 | 0.94098 |
| MA0040.1 | 1.24388 |
| MA0041.1 | 0.847069 |
| MA0042.1 | 0.810843 |
| MA0043.1 | 1.32783 |
| MA0046.1 | 1.31611 |
| MA0048.1 | 0.341392 |
| MA0050.1 | 0.81185 |
| MA0051.1 | 0.936307 |
| MA0052.1 | 1.24796 |
| MA0055.1 | 0.190716 |
| MA0056.1 | 0 |
| MA0057.1 | 0.333427 |
| MA0058.1 | 1.70328 |
| MA0059.1 | 1.70014 |
| MA0060.1 | 0.492218 |
| MA0061.1 | 0.456531 |
| MA0063.1 | 0 |
| MA0066.1 | 0.941452 |
| MA0067.1 | 1.65513 |
| MA0068.1 | 0.405474 |
| MA0069.1 | 1.31207 |
| MA0070.1 | 1.30033 |
| MA0071.1 | 0.897953 |
| MA0072.1 | 1.29561 |
| MA0073.1 | 0.0185922 |
| MA0074.1 | 0.935474 |
| MA0076.1 | 0.734647 |
| MA0077.1 | 1.28751 |
| MA0078.1 | 1.04495 |
| MA0081.1 | 0.714712 |
| MA0083.1 | 1.33535 |
| MA0084.1 | 1.84562 |
| MA0087.1 | 1.29304 |
| MA0088.1 | 0.257905 |
| MA0089.1 | 0 |
| MA0090.1 | 0.751469 |
| MA0091.1 | 0.829044 |
| MA0092.1 | 0.785956 |
| MA0093.1 | 2.626 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.956299 |
| MA0101.1 | 1.55947 |
| MA0103.1 | 0.628063 |
| MA0105.1 | 1.5295 |
| MA0106.1 | 0.986396 |
| MA0107.1 | 1.36919 |
| MA0108.2 | 1.15387 |
| MA0109.1 | 0 |
| MA0111.1 | 0.767139 |
| MA0113.1 | 1.00436 |
| MA0114.1 | 3.41476 |
| MA0115.1 | 1.57693 |
| MA0116.1 | 0.560723 |
| MA0117.1 | 1.36676 |
| MA0119.1 | 2.7939 |
| MA0122.1 | 1.39371 |
| MA0124.1 | 1.53432 |
| MA0125.1 | 1.44766 |
| MA0130.1 | 0 |
| MA0131.1 | 2.4174 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.35921 |
| MA0136.1 | 0.948776 |
| MA0139.1 | 1.12079 |
| MA0140.1 | 0.894983 |
| MA0141.1 | 0.712476 |
| MA0142.1 | 1.12317 |
| MA0143.1 | 1.00455 |
| MA0144.1 | 0.531867 |
| MA0145.1 | 0.752137 |
| MA0146.1 | 0.707589 |
| MA0147.1 | 2.37462 |
| MA0148.1 | 0.854239 |
| MA0149.1 | 0.884158 |
| MA0062.2 | 0.449458 |
| MA0035.2 | 0.894194 |
| MA0039.2 | 0.195278 |
| MA0138.2 | 1.04628 |
| MA0002.2 | 0.476938 |
| MA0137.2 | 0.666381 |
| MA0104.2 | 1.2307 |
| MA0047.2 | 0.973066 |
| MA0112.2 | 0.731309 |
| MA0065.2 | 2.13692 |
| MA0150.1 | 0.744617 |
| MA0151.1 | 0 |
| MA0152.1 | 0.902317 |
| MA0153.1 | 1.43021 |
| MA0154.1 | 0.312019 |
| MA0155.1 | 4.65556 |
| MA0156.1 | 0.669101 |
| MA0157.1 | 1.09377 |
| MA0158.1 | 0 |
| MA0159.1 | 0.565904 |
| MA0160.1 | 0.871361 |
| MA0161.1 | 0 |
| MA0162.1 | 0.8915 |
| MA0163.1 | 0.122425 |
| MA0164.1 | 1.01792 |
| MA0080.2 | 0.643061 |
| MA0018.2 | 0.987913 |
| MA0099.2 | 0.902716 |
| MA0079.2 | 0.0373086 |
| MA0102.2 | 1.88331 |
| MA0258.1 | 0.519674 |
| MA0259.1 | 1.40979 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| CTCF#10664 | 3 | 5.36025637307503 | 0.006492509252767 | 0.0279697716392251 |
| CTCFL#140690 | 2 | 13.1643162393162 | 0.00743336703699601 | 0.0306814772942665 |
| E2F6#1876 | 3 | 5.01715573169739 | 0.0079176980688633 | 0.0322560644645816 |
| ELF1#1997 | 3 | 4.25809795880754 | 0.0129517987505461 | 0.0462721208807951 |
| ETS1#2113 | 3 | 9.72876092220234 | 0.00108584009258484 | 0.00762995717079107 |
| FOXA1#3169 | 3 | 11.0814197493855 | 0.00073475527569867 | 0.00581782458216022 |
| FOXA2#3170 | 2 | 16.4203091684435 | 0.00481068235210548 | 0.0225919714992376 |
| GABPB1#2553 | 3 | 7.06768383618217 | 0.00283221282541742 | 0.01542438730113 |
| GTF2F1#2962 | 3 | 12.7396608767577 | 0.000483552504743859 | 0.00434386203706726 |
| MAX#4149 | 3 | 6.45255550900712 | 0.00372191383426551 | 0.0186728615524261 |
| MXI1#4601 | 3 | 9.9615716287593 | 0.00101147054125902 | 0.00720776281785965 |
| MYC#4609 | 3 | 5.2222818716094 | 0.00702084375574015 | 0.0294785680230661 |
| NANOG#79923 | 3 | 29.2447784810127 | 3.99627955670032e-05 | 0.000738180828833083 |
| NRF1#4899 | 3 | 12.2102794477109 | 0.000549217240102001 | 0.00471436667535242 |
| SIN3A#25942 | 3 | 5.40888472681514 | 0.00631896197799152 | 0.0277090343040457 |
| SMC3#9126 | 2 | 10.0299552299552 | 0.012665637976747 | 0.0457569118493715 |
| TAF7#6879 | 3 | 11.4330694049239 | 0.000669018198194583 | 0.00543578587219885 |
| USF1#7391 | 3 | 6.36149927720796 | 0.0038840405729056 | 0.0190452750548706 |
| YY1#7528 | 3 | 4.91117074985386 | 0.00844145534180826 | 0.0329736752232155 |
| ZNF143#7702 | 3 | 13.5008765522279 | 0.000406280496299717 | 0.00389387251106232 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
