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Coexpression cluster:C1762: Difference between revisions

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|tf_chipseq_enrich=FOS#2353;4:7.19836424711553:0.000694785845338251:0.00559638584770026!FOSL2#2355;3:10.158120362737:0.00188199070341543:0.0110915426372103!REST#5978;4:7.72002297290242:0.000528636377365057:0.00457303525351025
|tf_chipseq_enrich=FOS#2353;4:7.19836424711553:0.000694785845338251:0.00559638584770026!FOSL2#2355;3:10.158120362737:0.00188199070341543:0.0110915426372103!REST#5978;4:7.72002297290242:0.000528636377365057:0.00457303525351025
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}}
}}

Revision as of 15:05, 26 November 2012


Full id: C1762_Basophils_Natural_CD8_heart_Peripheral_CD4_CD14



Phase1 CAGE Peaks

Hg19::chr16:50187556..50187567,+p8@PAPD5
Hg19::chr5:58334901..58334921,-p32@PDE4D
Hg19::chr5:58334931..58334942,-p33@PDE4D
Hg19::chr5:58334948..58334962,-p21@PDE4D
Hg19::chr5:58334967..58334976,-p44@PDE4D


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:00041153',5'-cyclic-AMP phosphodiesterase activity0.0226637230903166
GO:0005626insoluble fraction0.0317095964097316
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity0.0317095964097316
GO:0004112cyclic-nucleotide phosphodiesterase activity0.0317095964097316
GO:0003887DNA-directed DNA polymerase activity0.0317095964097316



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>


Cell Type
Ontology termp-valuen
mature alpha-beta T cell5.54e-0818
alpha-beta T cell5.54e-0818
immature T cell5.54e-0818
mature T cell5.54e-0818
immature alpha-beta T cell5.54e-0818
T cell9.23e-0725
pro-T cell9.23e-0725
circulating cell9.32e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235347.198364247115530.0006947858453382510.00559638584770026
FOSL2#2355310.1581203627370.001881990703415430.0110915426372103
REST#597847.720022972902420.0005286363773650570.00457303525351025



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.