MCL coexpression mm9:334
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0019198 | transmembrane receptor protein phosphatase activity | 0.0185175039719498 |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | 0.0185175039719498 |
| GO:0021879 | forebrain neuron differentiation | 0.0475499523893807 |
| GO:0007191 | dopamine receptor, adenylate cyclase activating pathway | 0.0475499523893807 |
| GO:0004727 | prenylated protein tyrosine phosphatase activity | 0.0475499523893807 |
| GO:0021872 | generation of neurons in the forebrain | 0.0475499523893807 |
| GO:0007190 | adenylate cyclase activation | 0.0475499523893807 |
| GO:0045762 | positive regulation of adenylate cyclase activity | 0.0475499523893807 |
| GO:0031281 | positive regulation of cyclase activity | 0.0475499523893807 |
| GO:0051349 | positive regulation of lyase activity | 0.0475499523893807 |
| GO:0045761 | regulation of adenylate cyclase activity | 0.0475499523893807 |
| GO:0031279 | regulation of cyclase activity | 0.0475499523893807 |
| GO:0007212 | dopamine receptor signaling pathway | 0.0475499523893807 |
| GO:0051339 | regulation of lyase activity | 0.0475499523893807 |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | 0.0493029557375933 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| hippocampal neuron | 6.29e-14 | 3 |
| neuron of cerebral cortex | 3.55e-07 | 6 |
| Ontology term | p-value | n |
|---|---|---|
| corpus striatum | 1.03e-13 | 5 |
| striatum | 1.03e-13 | 5 |
| ventral part of telencephalon | 1.03e-13 | 5 |
| future corpus striatum | 1.03e-13 | 5 |
| basal ganglion | 1.29e-08 | 8 |
| nuclear complex of neuraxis | 1.29e-08 | 8 |
| aggregate regional part of brain | 1.29e-08 | 8 |
| collection of basal ganglia | 1.29e-08 | 8 |
| cerebral subcortex | 1.29e-08 | 8 |
| regional part of forebrain | 1.74e-07 | 39 |
| forebrain | 1.74e-07 | 39 |
| future forebrain | 1.74e-07 | 39 |
| anterior neural tube | 2.91e-07 | 40 |
| gray matter | 6.76e-07 | 34 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0146026 |
| MA0004.1 | 0.126659 |
| MA0006.1 | 0.699047 |
| MA0007.1 | 0.376537 |
| MA0009.1 | 1.14834 |
| MA0014.1 | 0.208889 |
| MA0017.1 | 1.20061 |
| MA0019.1 | 0.30302 |
| MA0024.1 | 0.415603 |
| MA0025.1 | 0.660968 |
| MA0027.1 | 2.04174 |
| MA0028.1 | 0.186822 |
| MA0029.1 | 0.397373 |
| MA0030.1 | 0.402861 |
| MA0031.1 | 0.975206 |
| MA0038.1 | 0.62805 |
| MA0040.1 | 0.463641 |
| MA0041.1 | 0.607211 |
| MA0042.1 | 0.273359 |
| MA0043.1 | 0.53743 |
| MA0046.1 | 0.483941 |
| MA0048.1 | 0.715446 |
| MA0050.1 | 0.149886 |
| MA0051.1 | 0.226644 |
| MA0052.1 | 0.47061 |
| MA0055.1 | 0.0383365 |
| MA0056.1 | 0 |
| MA0057.1 | 0.14014 |
| MA0058.1 | 0.264426 |
| MA0059.1 | 0.588924 |
| MA0060.1 | 1.06672 |
| MA0061.1 | 0.0296722 |
| MA0063.1 | 0 |
| MA0066.1 | 0.609771 |
| MA0067.1 | 0.764133 |
| MA0068.1 | 0.449127 |
| MA0069.1 | 1.18716 |
| MA0070.1 | 1.16914 |
| MA0071.1 | 1.43385 |
| MA0072.1 | 1.15342 |
| MA0073.1 | 9.2374 |
| MA0074.1 | 0.550954 |
| MA0076.1 | 0.064121 |
| MA0077.1 | 1.11336 |
| MA0078.1 | 0.250627 |
| MA0081.1 | 0.644573 |
| MA0083.1 | 0.536725 |
| MA0084.1 | 1.07765 |
| MA0087.1 | 0.4987 |
| MA0088.1 | 0.41334 |
| MA0089.1 | 0 |
| MA0090.1 | 0.708683 |
| MA0091.1 | 0.134352 |
| MA0092.1 | 0.349135 |
| MA0093.1 | 0.196448 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.180237 |
| MA0101.1 | 0.292678 |
| MA0103.1 | 0.218786 |
| MA0105.1 | 0.669937 |
| MA0106.1 | 0.256379 |
| MA0107.1 | 0.0580742 |
| MA0108.2 | 0.320962 |
| MA0109.1 | 0 |
| MA0111.1 | 0.115252 |
| MA0113.1 | 0.2357 |
| MA0114.1 | 0.287365 |
| MA0115.1 | 1.33437 |
| MA0116.1 | 0.0459718 |
| MA0117.1 | 0.511373 |
| MA0119.1 | 1.0261 |
| MA0122.1 | 0.528896 |
| MA0124.1 | 0.714453 |
| MA0125.1 | 0.646095 |
| MA0130.1 | 0 |
| MA0131.1 | 0.810613 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.569948 |
| MA0136.1 | 0.583392 |
| MA0139.1 | 0.35839 |
| MA0140.1 | 0.180161 |
| MA0141.1 | 0.892059 |
| MA0142.1 | 0.361451 |
| MA0143.1 | 1.28115 |
| MA0144.1 | 0.293322 |
| MA0145.1 | 0.663753 |
| MA0146.1 | 0.0147284 |
| MA0147.1 | 0.911853 |
| MA0148.1 | 0.836385 |
| MA0149.1 | 5.78394 |
| MA0062.2 | 0.125873 |
| MA0035.2 | 0.18328 |
| MA0039.2 | 0.145091 |
| MA0138.2 | 0.293335 |
| MA0002.2 | 0.366396 |
| MA0137.2 | 0.514948 |
| MA0104.2 | 0.988517 |
| MA0047.2 | 0.626771 |
| MA0112.2 | 0.295523 |
| MA0065.2 | 0.0863447 |
| MA0150.1 | 0.11804 |
| MA0151.1 | 0 |
| MA0152.1 | 0.62695 |
| MA0153.1 | 0.584906 |
| MA0154.1 | 0.158528 |
| MA0155.1 | 0.354426 |
| MA0156.1 | 0.0637507 |
| MA0157.1 | 0.8915 |
| MA0158.1 | 0 |
| MA0159.1 | 0.610644 |
| MA0160.1 | 0.844124 |
| MA0161.1 | 0 |
| MA0162.1 | 0.159338 |
| MA0163.1 | 0.2152 |
| MA0164.1 | 0.201705 |
| MA0080.2 | 0.464846 |
| MA0018.2 | 0.208409 |
| MA0099.2 | 0.288477 |
| MA0079.2 | 1.99251 |
| MA0102.2 | 1.12863 |
| MA0258.1 | 0.107482 |
| MA0259.1 | 0.124592 |
| MA0442.1 | 0 |
