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CL:0000557

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Name:granulocyte monocyte progenitor cell
Namespace:FANTOM
Definition:"A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251]
Synonyms: "CFU-C , Colony forming unit in culture" BROAD [1]
"CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
Comments:Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID: 19243617). GMPs are reportedly CD34-positive, CD38-positive, CD45RA-positive, and CD123-positive.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0000763(myeloid cell),CL:0001012(CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor),CL:1001610(bone marrow hematopoietic cell)
develops_from:CL:0000049(common myeloid progenitor)
part_of:UBERON:0002371(bone marrow)



Children


disjoint from:CL:0000049 (common myeloid progenitor),CL:0000050 (megakaryocyte-erythroid progenitor cell)
derives from:FF:0000070 (granulocyte macrophage progenitor cell sample)
develops from:CL:0000835 (myeloblast),CL:0002009 (macrophage dendritic cell progenitor),CL:0002028 (basophil mast progenitor cell)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

  • 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
  • 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
  • 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
  • 12131-128D7 (granulocyte macrophage progenitor, donor1)
  • 12135-128E2 (granulocyte macrophage progenitor, donor2)
  • 12139-128E6 (granulocyte macrophage progenitor, donor3)

Mouse (Mus musculus)

  • 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
  • 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
  • 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
  • 12131-128D7 (granulocyte macrophage progenitor, donor1)
  • 12135-128E2 (granulocyte macrophage progenitor, donor2)
  • 12139-128E6 (granulocyte macrophage progenitor, donor3)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000557 (granulocyte monocyte progenitor cell), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
1.22e-136FFCP PHASE1:Hg19::chr1:161187824..161187847,+#_a11ccc43e34d0b48429aa8ea50fb7bd1p@chr1:161187824..161187847, +
1.22e-136FFCP PHASE2:Hg19::chr1:161187824..161187847,+#_a11ccc43e34d0b48429aa8ea50fb7bd1p@chr1:161187824..161187847, +
6.46e-132FFCP PHASE2:Hg19::chr16:50313426..50313459,+#_24bf4e1d003a175beb60951b15c26690p@chr16:50313426..50313459, +
6.46e-132FFCP PHASE1:Hg19::chr16:50313426..50313459,+#_24bf4e1d003a175beb60951b15c26690p@chr16:50313426..50313459, +
1.98e-131FFCP PHASE1:Hg19::chr1:161188661..161188679,+#_0cd7adf95883f31a4e11aec714e9d502p@chr1:161188661..161188679, +
1.98e-131FFCP PHASE2:Hg19::chr1:161188661..161188679,+#_0cd7adf95883f31a4e11aec714e9d502p@chr1:161188661..161188679, +
6.11e-130FFCP PHASE2:Hg19::chr18:2847062..2847071,+#_edf397f59b453398022e9f69333c6441p7@EMILIN2
6.11e-130FFCP PHASE1:Hg19::chr18:2847062..2847071,+#_edf397f59b453398022e9f69333c6441p7@EMILIN2
4.57e-129FFCP PHASE2:Hg19::chr7:77050554..77050601,+#_d2dc56dcc174792eac79892dfc152325p@chr7:77050554..77050601, +
4.57e-129FFCP PHASE1:Hg19::chr7:77050554..77050601,+#_d2dc56dcc174792eac79892dfc152325p@chr7:77050554..77050601, +
9.16e-128FFCP PHASE1:Hg19::chr1:161188746..161188758,+#_a5086834f8a8e902bfc00c1ea6446a93p@chr1:161188746..161188758, +
9.16e-128FFCP PHASE2:Hg19::chr1:161188746..161188758,+#_a5086834f8a8e902bfc00c1ea6446a93p@chr1:161188746..161188758, +
8.22e-127FFCP PHASE2:Hg19::chr17:7482481..7482508,-#_cf49226623cce6110a28f7f564fd9d4bp@chr17:7482481..7482508, -
8.22e-127FFCP PHASE1:Hg19::chr17:7482481..7482508,-#_cf49226623cce6110a28f7f564fd9d4bp@chr17:7482481..7482508, -
1.66e-126FFCP PHASE1:Hg19::chr19:18288651..18288682,+#_9fe797cdfa67f5df82073d304674d271p5@IFI30
1.66e-126FFCP PHASE2:Hg19::chr19:18288651..18288682,+#_9fe797cdfa67f5df82073d304674d271p5@IFI30
1.87e-125FFCP PHASE2:Hg19::chr4:3387239..3387324,-#_9ca27ea82a3341168c7b27a765c662a2p@chr4:3387239..3387324, -
1.87e-125FFCP PHASE1:Hg19::chr4:3387239..3387324,-#_9ca27ea82a3341168c7b27a765c662a2p@chr4:3387239..3387324, -
1.83e-123FFCP PHASE1:Hg19::chr7:2832730..2832791,+#_214513c8cc313667afb0e2059bbc7d77+, p@chr7:2832730..2832791
1.83e-123FFCP PHASE2:Hg19::chr7:2832730..2832791,+#_214513c8cc313667afb0e2059bbc7d77p@chr7:2832730..2832791, +
2.42e-122FFCP PHASE2:Hg19::chr5:180242646..180242657,-#_3d6795bff4765484f0d06fb37b4bec5ep15@MGAT1
2.42e-122FFCP PHASE1:Hg19::chr5:180242646..180242657,-#_3d6795bff4765484f0d06fb37b4bec5ep15@MGAT1
4.19e-122FFCP PHASE2:Hg19::chr19:18288828..18288861,+#_9be0fa50ddec0d252e25307b3c21ecf1p7@IFI30
4.19e-122FFCP PHASE1:Hg19::chr19:18288828..18288861,+#_9be0fa50ddec0d252e25307b3c21ecf1p7@IFI30
1.2e-121FFCP PHASE1:Hg19::chr1:111743000..111743011,+#_78d1a4bd88b85f42876d3c7385eb1407p8@CHI3L2
1.2e-121FFCP PHASE2:Hg19::chr1:111743000..111743011,+#_78d1a4bd88b85f42876d3c7385eb1407p8@CHI3L2
3.34e-121FFCP PHASE2:Hg19::chr17:40168698..40168726,-#_24dd7c92172312785d7b9a859b0af497p1@AK126179
3.34e-121FFCP PHASE1:Hg19::chr17:40168698..40168726,-#_24dd7c92172312785d7b9a859b0af497p1@AK126179
3.43e-120FFCP PHASE1:Hg19::chr19:18286116..18286156,+#_fea4df9e87cfff344f1b16237862724cp@chr19:18286116..18286156, +
3.43e-120FFCP PHASE2:Hg19::chr19:18286116..18286156,+#_fea4df9e87cfff344f1b16237862724cp@chr19:18286116..18286156, +
1.26e-119FFCP PHASE2:Hg19::chr17:72542163..72542182,-#_f5182f03712a03bd92c23e7d9d9b5d91p2@CD300C
1.26e-119FFCP PHASE1:Hg19::chr17:72542163..72542182,-#_f5182f03712a03bd92c23e7d9d9b5d91p2@CD300C
1.37e-118FFCP PHASE1:Hg19::chr2:38358217..38358244,+#_39b203bbe6a3dd0c86757cfd75a3ab7cp1@CYP1B1-AS1
1.37e-118FFCP PHASE2:Hg19::chr2:38358217..38358244,+#_39b203bbe6a3dd0c86757cfd75a3ab7cp1@CYP1B1-AS1
1.51e-118FFCP PHASE2:Hg19::chr15:65174546..65174583,-#_17f36752570be8be38771f7a9aac0cc3p@chr15:65174546..65174583, -
1.51e-118FFCP PHASE1:Hg19::chr15:65174546..65174583,-#_17f36752570be8be38771f7a9aac0cc3p@chr15:65174546..65174583, -
3.4e-118FFCP PHASE2:Hg19::chr4:159727272..159727307,+#_5a5aebb1de2cd58d6057663e0a14dadap7@FNIP2
3.4e-118FFCP PHASE1:Hg19::chr4:159727272..159727307,+#_5a5aebb1de2cd58d6057663e0a14dadap7@FNIP2
1.14e-117FFCP PHASE1:Hg19::chr4:185314125..185314143,-#_fc42dc1f210fe44375815a72b1301e36p@chr4:185314125..185314143, -
1.14e-117FFCP PHASE2:Hg19::chr4:185314125..185314143,-#_fc42dc1f210fe44375815a72b1301e36p@chr4:185314125..185314143, -
4.04e-117FFCP PHASE2:Hg19::chr3:149531627..149531651,+#_44d68d7e0ab0d15e307f056bcec34bafp7@RNF13
4.04e-117FFCP PHASE1:Hg19::chr3:149531627..149531651,+#_44d68d7e0ab0d15e307f056bcec34bafp7@RNF13
7.68e-117FFCP PHASE1:Hg19::chr1:161188686..161188721,+#_12fb7373cd683929d62fe8f184860ef9p@chr1:161188686..161188721, +
7.68e-117FFCP PHASE2:Hg19::chr1:161188686..161188721,+#_12fb7373cd683929d62fe8f184860ef9+, p@chr1:161188686..161188721
1.34e-116FFCP PHASE1:Hg19::chr2:119726719..119726744,+#_5b3fbdb5f0242d8b7929a4cb26d41b11p@chr2:119726719..119726744, +
1.34e-116FFCP PHASE2:Hg19::chr2:119726719..119726744,+#_5b3fbdb5f0242d8b7929a4cb26d41b11p@chr2:119726719..119726744, +
1.55e-116FFCP PHASE2:Hg19::chr19:52299474..52299504,-#_ad75fad916de90af2d89686b92630a32p@chr19:52299474..52299504, -
1.55e-116FFCP PHASE1:Hg19::chr19:52299474..52299504,-#_ad75fad916de90af2d89686b92630a32p@chr19:52299474..52299504, -
5.12e-116FFCP PHASE1:Hg19::chr5:131280548..131280574,-#_72e5cc66b7417f91917ea204887d60f5p1@ENST00000425320
5.12e-116FFCP PHASE2:Hg19::chr5:131280548..131280574,-#_72e5cc66b7417f91917ea204887d60f5p1@ENST00000425320
9.64e-116FFCP PHASE1:Hg19::chr10:73648356..73648408,-#_0ce618f8285f33af865d16ed310d79edp@chr10:73648356..73648408, -
9.64e-116FFCP PHASE2:Hg19::chr10:73648356..73648408,-#_0ce618f8285f33af865d16ed310d79edp@chr10:73648356..73648408, -
9.84e-116FFCP PHASE2:Hg19::chr4:185314151..185314178,-#_94c6f6a7d52c066869db179f7a78538cp@chr4:185314151..185314178, -
9.84e-116FFCP PHASE1:Hg19::chr4:185314151..185314178,-#_94c6f6a7d52c066869db179f7a78538cp@chr4:185314151..185314178, -
1.24e-115FFCP PHASE1:Hg19::chr2:145429606..145429658,+#_99ff12aa13396b3d8b19283b2734df50p@chr2:145429606..145429658, +
1.24e-115FFCP PHASE2:Hg19::chr2:145429606..145429658,+#_99ff12aa13396b3d8b19283b2734df50p@chr2:145429606..145429658, +
3.24e-115FFCP PHASE1:Hg19::chr19:18288064..18288080,+#_2456ed7b3af590b72e7384db85e26732p@chr19:18288064..18288080, +
3.24e-115FFCP PHASE2:Hg19::chr19:18288064..18288080,+#_2456ed7b3af590b72e7384db85e26732p@chr19:18288064..18288080, +
4.02e-115FFCP PHASE2:Hg19::chrX:153286067..153286101,-#_6f07e392e342ff5ab8a2ffea4b586f41p@chrX:153286067..153286101, -
4.02e-115FFCP PHASE1:Hg19::chrX:153286067..153286101,-#_6f07e392e342ff5ab8a2ffea4b586f41p@chrX:153286067..153286101, -
1.44e-114FFCP PHASE2:Hg19::chr4:185314188..185314207,-#_46014b0d1434df2a679006680ca89561p@chr4:185314188..185314207, -
1.44e-114FFCP PHASE1:Hg19::chr4:185314188..185314207,-#_46014b0d1434df2a679006680ca89561p@chr4:185314188..185314207, -
1.54e-114FFCP PHASE1:Hg19::chrX:37664331..37664352,+#_bd9877b2f7ff42599e300623f50e74c2p@chrX:37664331..37664352, +
1.54e-114FFCP PHASE2:Hg19::chrX:37664331..37664352,+#_bd9877b2f7ff42599e300623f50e74c2p@chrX:37664331..37664352, +
1.59e-114FFCP PHASE2:Hg19::chr1:161188826..161188842,+#_ba6090bb00a3c8d1e36e4c4616645866p@chr1:161188826..161188842, +
1.59e-114FFCP PHASE1:Hg19::chr1:161188826..161188842,+#_ba6090bb00a3c8d1e36e4c4616645866p@chr1:161188826..161188842, +
1.87e-114FFCP PHASE1:Hg19::chr1:150724282..150724308,-#_2e8feb13f2bfbe65ed2dcb5b11cec14cp8@CTSS
1.87e-114FFCP PHASE2:Hg19::chr1:150724282..150724308,-#_2e8feb13f2bfbe65ed2dcb5b11cec14cp8@CTSS
5.37e-114FFCP PHASE1:Hg19::chr2:145276939..145276960,+#_d5526812523aeb2ba54037baf3542b11p2@ZEB2-AS1
5.37e-114FFCP PHASE2:Hg19::chr2:145276939..145276960,+#_d5526812523aeb2ba54037baf3542b11p2@ZEB2-AS1
6.51e-114FFCP PHASE1:Hg19::chr19:18285955..18285972,+#_449b747ceba67a5a019fcb5409c2d137p@chr19:18285955..18285972, +
6.51e-114FFCP PHASE2:Hg19::chr19:18285955..18285972,+#_449b747ceba67a5a019fcb5409c2d137p@chr19:18285955..18285972, +
9.3e-114FFCP PHASE2:Hg19::chr8:116588888..116588904,+#_c6d2ce9ebfe03a69507efaf4d0a39dfep@chr8:116588888..116588904, +
9.3e-114FFCP PHASE1:Hg19::chr8:116588888..116588904,+#_c6d2ce9ebfe03a69507efaf4d0a39dfep@chr8:116588888..116588904, +
1.42e-113FFCP PHASE1:Hg19::chr1:145610717..145610730,+#_dc4b750e1157c55dde9fc37a7f56c0dcp4@RNF115
1.42e-113FFCP PHASE2:Hg19::chr1:145610717..145610730,+#_dc4b750e1157c55dde9fc37a7f56c0dcp4@RNF115
4.0e-113FFCP PHASE1:Hg19::chr2:129283966..129283970,+#_d68a54eefcea00359ff54066b91d349ep@chr2:129283966..129283970, +
4.0e-113FFCP PHASE2:Hg19::chr2:129283966..129283970,+#_d68a54eefcea00359ff54066b91d349ep@chr2:129283966..129283970, +
5.85e-113FFCP PHASE2:Hg19::chr19:18283959..18283993,+#_2ba044c8a0ff09d83891675c88fff299p@chr19:18283959..18283993, +
5.85e-113FFCP PHASE1:Hg19::chr19:18283959..18283993,+#_2ba044c8a0ff09d83891675c88fff299p@chr19:18283959..18283993, +
8.33e-113FFCP PHASE2:Hg19::chr20:1517991..1518011,-#_bd89701fa99853b2ceda033fe7f59b58p@chr20:1517991..1518011, -
8.33e-113FFCP PHASE1:Hg19::chr20:1517991..1518011,-#_bd89701fa99853b2ceda033fe7f59b58p@chr20:1517991..1518011, -
1.49e-112FFCP PHASE1:Hg19::chr1:108593061..108593077,+#_c8b467d9bfef56c6da822775376fc5d8p@chr1:108593061..108593077, +
1.49e-112FFCP PHASE2:Hg19::chr1:108593061..108593077,+#_c8b467d9bfef56c6da822775376fc5d8p@chr1:108593061..108593077, +
1.89e-112FFCP PHASE2:Hg19::chr19:18288914..18288931,-#_5990873cee06711a2f86ba43a7ed2600p5@CU676849, p5@CU689079
1.89e-112FFCP PHASE1:Hg19::chr19:18288914..18288931,-#_5990873cee06711a2f86ba43a7ed2600p5@CU676849, p5@CU689079
4.76e-112FFCP PHASE1:Hg19::chr19:18288514..18288554,+#_57b23fa5e5585f31033b216f03b2dd5fp6@IFI30
4.76e-112FFCP PHASE2:Hg19::chr19:18288514..18288554,+#_57b23fa5e5585f31033b216f03b2dd5fp6@IFI30
6.25e-112FFCP PHASE2:Hg19::chr5:180242576..180242585,-#_e45d6f3c004c29ad8cce7f6a1cca3b18p12@MGAT1
6.25e-112FFCP PHASE1:Hg19::chr5:180242576..180242585,-#_e45d6f3c004c29ad8cce7f6a1cca3b18p12@MGAT1
1.15e-111FFCP PHASE1:Hg19::chr7:128503395..128503414,+#_ccea79432ea4f3dc33d5b43cc8fc97e1p@chr7:128503395..128503414, +
1.15e-111FFCP PHASE2:Hg19::chr7:128503395..128503414,+#_ccea79432ea4f3dc33d5b43cc8fc97e1p@chr7:128503395..128503414, +
1.58e-111FFCP PHASE2:Hg19::chr8:53373491..53373506,-#_ece0ae84f57e0121b4d417edadc07225p4@ST18
1.58e-111FFCP PHASE1:Hg19::chr8:53373491..53373506,-#_ece0ae84f57e0121b4d417edadc07225p4@ST18
3.68e-111FFCP PHASE1:Hg19::chr7:6066589..6066602,-#_74aae7e7528f0b4a87d6f02920a6cd60p4@EIF2AK1
3.68e-111FFCP PHASE2:Hg19::chr7:6066589..6066602,-#_74aae7e7528f0b4a87d6f02920a6cd60p4@EIF2AK1
3.91e-111FFCP PHASE2:Hg19::chr17:7483714..7483726,+#_649c3d37e3e9f1a2879eb418b36ea4d7p@chr17:7483714..7483726, +
3.91e-111FFCP PHASE1:Hg19::chr17:7483714..7483726,+#_649c3d37e3e9f1a2879eb418b36ea4d7p@chr17:7483714..7483726, +
1.05e-110FFCP PHASE1:Hg19::chr1:161187774..161187799,+#_60d9eafbb55b8e6fefad623b5cbb80f9p@chr1:161187774..161187799, +
1.05e-110FFCP PHASE2:Hg19::chr1:161187774..161187799,+#_60d9eafbb55b8e6fefad623b5cbb80f9+, p@chr1:161187774..161187799