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Coexpression cluster:C2101

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Full id: C2101_adult_B_xeroderma_lymphoma_signet_appendix_tonsil



Phase1 CAGE Peaks

Hg19::chr11:119622609..119622621,+p@chr11:119622609..119622621
+
Hg19::chr11:119622634..119622668,+p@chr11:119622634..119622668
+
Hg19::chr17:39928110..39928152,-p5@JUP
Hg19::chr1:25255329..25255339,-p21@RUNX3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005916fascia adherens0.014008857951139
GO:0009898internal side of plasma membrane0.014008857951139
GO:0030057desmosome0.014008857951139
GO:0050680negative regulation of epithelial cell proliferation0.014008857951139
GO:0005913cell-cell adherens junction0.014008857951139
GO:0030018Z disc0.014008857951139
GO:0031674I band0.014580004135363
GO:0050678regulation of epithelial cell proliferation0.022007762260344
GO:0050673epithelial cell proliferation0.022007762260344
GO:0014704intercalated disc0.0249241607803606
GO:0030017sarcomere0.0249241607803606
GO:0030016myofibril0.0249241607803606
GO:0005912adherens junction0.0249241607803606
GO:0044449contractile fiber part0.0255973422701364
GO:0043292contractile fiber0.0255973422701364
GO:0043296apical junction complex0.0370325943749413
GO:0016327apicolateral plasma membrane0.0370325943749413



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
lymphocyte of B lineage1.23e-3624
pro-B cell1.23e-3624
lymphoid lineage restricted progenitor cell8.91e-2552
lymphocyte3.22e-2453
common lymphoid progenitor3.22e-2453
nucleate cell3.64e-2355
leukocyte3.81e-17136
hematopoietic cell1.75e-16177
hematopoietic lineage restricted progenitor cell1.72e-15120
hematopoietic oligopotent progenitor cell1.14e-14161
hematopoietic multipotent progenitor cell1.14e-14161
hematopoietic stem cell8.94e-14168
angioblastic mesenchymal cell8.94e-14168
nongranular leukocyte3.42e-12115
B cell3.69e-1014
mature B cell6.77e-092
pre-B-II cell6.77e-092
transitional stage B cell6.77e-092
small pre-B-II cell6.77e-092
immature B cell6.77e-092
Langerhans cell4.45e-085
histamine secreting cell1.00e-075
biogenic amine secreting cell1.00e-075
granulocytopoietic cell1.00e-075
mast cell1.00e-075
mast cell progenitor1.00e-075
basophil mast progenitor cell1.00e-075
circulating cell5.74e-076
Uber Anatomy
Ontology termp-valuen
hemopoietic organ2.84e-147
immune organ2.84e-147
spleen4.91e-133
gastrointestinal system mesentery4.91e-133
stomach region4.91e-133
mesentery4.91e-133
gastrointestinal system serosa4.91e-133
mesentery of stomach4.91e-133
gut mesentery4.91e-133
dorsal mesentery4.91e-133
dorsal mesogastrium4.91e-133
peritoneal cavity4.91e-133
spleen primordium4.91e-133
Disease
Ontology termp-valuen
lymphoma5.70e-2610


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.05935
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.14.51896
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.9994
MA0117.11.24497
MA0119.14.80079
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.10.481
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.12.64806
MA0155.11.61785
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.10.90014
MA0080.22.27911
MA0018.20.870662
MA0099.20.7872
MA0079.20.122011
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187948.9064668465690.00015887907472010.00199365273155023



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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