MCL coexpression mm9:196
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0050381 | unspecific monooxygenase activity | 0.000381407618093475 |
| GO:0004497 | monooxygenase activity | 0.000381407618093475 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.000381407618093475 |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 0.000381407618093475 |
| GO:0005792 | microsome | 0.000526622955370677 |
| GO:0042598 | vesicular fraction | 0.000526622955370677 |
| GO:0005624 | membrane fraction | 0.00162387099983086 |
| GO:0000267 | cell fraction | 0.00235617037791491 |
| GO:0020037 | heme binding | 0.00384637371565087 |
| GO:0046906 | tetrapyrrole binding | 0.00384637371565087 |
| GO:0006118 | electron transport | 0.00428262213647489 |
| GO:0006091 | generation of precursor metabolites and energy | 0.0107482932718783 |
| GO:0047685 | amine sulfotransferase activity | 0.0197017139437564 |
| GO:0032789 | unsaturated monocarboxylic acid metabolic process | 0.032001252598815 |
| GO:0032788 | saturated monocarboxylic acid metabolic process | 0.032001252598815 |
| GO:0015501 | glutamate:sodium symporter activity | 0.032001252598815 |
| GO:0005506 | iron ion binding | 0.0383846732732145 |
| GO:0050832 | defense response to fungus | 0.0383846732732145 |
| GO:0004813 | alanine-tRNA ligase activity | 0.0383846732732145 |
| GO:0006419 | alanyl-tRNA aminoacylation | 0.0383846732732145 |
| GO:0005783 | endoplasmic reticulum | 0.0399510662243412 |
| GO:0015813 | L-glutamate transport | 0.0465064880593034 |
| GO:0016491 | oxidoreductase activity | 0.049463534248198 |
| GO:0004499 | flavin-containing monooxygenase activity | 0.049463534248198 |
| GO:0015800 | acidic amino acid transport | 0.049463534248198 |
| GO:0005313 | L-glutamate transmembrane transporter activity | 0.049463534248198 |
| GO:0015172 | acidic amino acid transmembrane transporter activity | 0.049463534248198 |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | 0.049463534248198 |
| GO:0018149 | peptide cross-linking | 0.049463534248198 |
| GO:0005283 | sodium:amino acid symporter activity | 0.049463534248198 |
| GO:0000038 | very-long-chain fatty acid metabolic process | 0.049463534248198 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| metabolising cell | 2.99e-19 | 5 |
| endopolyploid cell | 2.99e-19 | 5 |
| parenchymal cell | 2.99e-19 | 5 |
| polyploid cell | 2.99e-19 | 5 |
| hepatocyte | 2.99e-19 | 5 |
| fibroblast | 3.20e-07 | 1 |
| hepatic stellate cell | 3.20e-07 | 1 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 5.96174e-10 |
| MA0004.1 | 0.113515 |
| MA0006.1 | 0.0723306 |
| MA0007.1 | 0.1023 |
| MA0009.1 | 0.651922 |
| MA0014.1 | 1.82322e-06 |
| MA0017.1 | 1.14607 |
| MA0019.1 | 1.26449 |
| MA0024.1 | 0.201902 |
| MA0025.1 | 1.83562 |
| MA0027.1 | 1.73381 |
| MA0028.1 | 0.00469088 |
| MA0029.1 | 1.05204 |
| MA0030.1 | 1.68338 |
| MA0031.1 | 0.509061 |
| MA0038.1 | 0.0717608 |
| MA0040.1 | 2.71402 |
| MA0041.1 | 1.18319 |
| MA0042.1 | 2.35786 |
| MA0043.1 | 0.298253 |
| MA0046.1 | 6.69001 |
| MA0048.1 | 0.0172467 |
| MA0050.1 | 0.955735 |
| MA0051.1 | 0.553749 |
| MA0052.1 | 0.244343 |
| MA0055.1 | 0.0120324 |
| MA0056.1 | 0 |
| MA0057.1 | 0.00115216 |
| MA0058.1 | 0.0526689 |
| MA0059.1 | 0.536405 |
| MA0060.1 | 0.0641488 |
| MA0061.1 | 0.187126 |
| MA0063.1 | 0 |
| MA0066.1 | 0.238824 |
| MA0067.1 | 0.494835 |
| MA0068.1 | 0.114397 |
| MA0069.1 | 0.244575 |
| MA0070.1 | 0.669544 |
| MA0071.1 | 0.144597 |
| MA0072.1 | 0.232276 |
| MA0073.1 | 4.52557e-06 |
| MA0074.1 | 0.443625 |
| MA0076.1 | 0.00759875 |
| MA0077.1 | 1.16821 |
| MA0078.1 | 1.04237 |
| MA0081.1 | 0.366807 |
| MA0083.1 | 0.297673 |
| MA0084.1 | 0.786978 |
| MA0087.1 | 0.266719 |
| MA0088.1 | 0.0186664 |
| MA0089.1 | 0 |
| MA0090.1 | 0.426204 |
| MA0091.1 | 0.294883 |
| MA0092.1 | 1.4139 |
| MA0093.1 | 0.0294259 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.189403 |
| MA0101.1 | 0.0639479 |
| MA0103.1 | 0.395058 |
| MA0105.1 | 0.000125033 |
| MA0106.1 | 0.0927014 |
| MA0107.1 | 0.21291 |
| MA0108.2 | 0.827339 |
| MA0109.1 | 0 |
| MA0111.1 | 0.45991 |
| MA0113.1 | 0.0804903 |
| MA0114.1 | 1.23104 |
| MA0115.1 | 0.812458 |
| MA0116.1 | 0.481245 |
| MA0117.1 | 0.276954 |
| MA0119.1 | 0.852948 |
| MA0122.1 | 0.291241 |
| MA0124.1 | 0.450339 |
| MA0125.1 | 0.390279 |
| MA0130.1 | 0 |
| MA0131.1 | 0.119827 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.868613 |
| MA0136.1 | 0.221605 |
| MA0139.1 | 0.0869605 |
| MA0140.1 | 0.421707 |
| MA0141.1 | 0.260018 |
| MA0142.1 | 0.488115 |
| MA0143.1 | 0.614089 |
| MA0144.1 | 0.188587 |
| MA0145.1 | 0.210793 |
| MA0146.1 | 3.11999e-05 |
| MA0147.1 | 0.110424 |
| MA0148.1 | 2.19794 |
| MA0149.1 | 0.0670828 |
| MA0062.2 | 0.000148268 |
| MA0035.2 | 0.43048 |
| MA0039.2 | 1.99301e-08 |
| MA0138.2 | 0.115828 |
| MA0002.2 | 0.279551 |
| MA0137.2 | 0.442238 |
| MA0104.2 | 0.0520505 |
| MA0047.2 | 1.36722 |
| MA0112.2 | 0.0485359 |
| MA0065.2 | 0.140242 |
| MA0150.1 | 0.47201 |
| MA0151.1 | 0 |
| MA0152.1 | 0.534196 |
| MA0153.1 | 7.69984 |
| MA0154.1 | 0.127142 |
| MA0155.1 | 0.00233076 |
| MA0156.1 | 0.0394812 |
| MA0157.1 | 0.144034 |
| MA0158.1 | 0 |
| MA0159.1 | 0.831881 |
| MA0160.1 | 0.304764 |
| MA0161.1 | 0 |
| MA0162.1 | 4.31864e-06 |
| MA0163.1 | 0.00130726 |
| MA0164.1 | 0.221989 |
| MA0080.2 | 0.380707 |
| MA0018.2 | 0.0652724 |
| MA0099.2 | 0.112699 |
| MA0079.2 | 1.68275e-14 |
| MA0102.2 | 0.835781 |
| MA0258.1 | 0.157368 |
| MA0259.1 | 0.0400618 |
| MA0442.1 | 0 |
