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Revision as of 17:11, 15 June 2012

Name:central nervous system
Definition:"The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord[GO]. The part of the nervous system which in vertebrates consists of the brain and spinal cord, to which sensory impulses are transmitted and from which motor impulses pass out, and which supervises and coordinates the activity of the entire nervous system[XAO]. Neuraxis plus retina[INCF]." [FB:gg, ISBN:3110148986, NLM:central+nervous+system, Wikipedia:Central_nervous_system, ZFIN:curator]
Xrefs:
links:

AAO:0000090
BILA:0000080
BTO:0000227
EFO:0000908
EHDAA:828
EHDAA2:0000225
EMAPA:16470
EMAPA:16754
EV:0100163
FBbt:00005094
FMA:55675
GAID:570
MA:0000167
MAT:0000457
MESH:A.08.186
ncithesaurus:Central_Nervous_System
NIF_GrossAnatomy:birnlex_1099
OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA
SCTID:278199004
TAO:0000012
VHOG:0000293
XAO:0000215

ZFA:0000012
Synonyms: "cerebrospinal axis" EXACT [FMA:55675]
"CNS" EXACT []
"neuraxis" EXACT [FMA:55675]
"systema nervosum centrale" EXACT [FMA:55675, FMA:TA]
Comments:ZFA retina NOT part_of CNS. XAO excludes retina in text def, retina part_of CNS. MA retina NOT part_of CNS. NIF_GA retina NOT part_of CNS. Fly also excludes it. EFO also excludes it. GO also excludes it.
Alt_id: UBERON:FBbt_00005094-FMA_55675-MA_0000167-XAO_0000215-ZFA_0000012
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000073(regional part of nervous system)
part_of:UBERON:0001016(nervous system),UBERON:0005743()



Children

part of:CL:0000047 (neuronal stem cell),CL:0000117 (CNS neuron (sensu Vertebrata)),FF:0000121 (central nervous system neuron),UBERON:0000125 (neural nucleus),CL:0000127 (astrocyte),CL:0000128 (oligodendrocyte),CL:0000129 (microglial cell),CL:0000878 (central nervous system macrophage),UBERON:0000955 (brain),UBERON:0001018 (axon tract),UBERON:0002020 (gray matter),UBERON:0002240 (spinal cord),UBERON:0002316 (white matter),CL:0002453 (oligodendrocyte precursor cell),CL:0002575 (central nervous system pericyte),UBERON:0005281 (ventricular system of central nervous system),UBERON:0006241 (future spinal cord),UBERON:0010743 (meningeal cluster),UBERON:0011215 (central nervous system cell part cluster),CL:2000029 (central nervous system neuron)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001017 (central nervous system), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
4.28e-131FFCP PHASE2:Hg19::chr12:106976678..106976708,+#_21c9bcf7a09aad2ac2d8caa5b89b1ff9p2@RFX4
4.28e-131FFCP PHASE1:Hg19::chr12:106976678..106976708,+#_21c9bcf7a09aad2ac2d8caa5b89b1ff9p2@RFX4
3.44e-127FFCP PHASE2:Hg19::chr12:106976774..106976788,+#_aaa098250003511dc050d447321915afp1@RFX4
3.44e-127FFCP PHASE1:Hg19::chr12:106976774..106976788,+#_aaa098250003511dc050d447321915afp1@RFX4
3.01e-125FFCP PHASE1:Hg19::chr5:11588907..11588967,-#_f49447efacce672d8f825a4512ba3078p3@CTNND2
3.01e-125FFCP PHASE2:Hg19::chr5:11588907..11588967,-#_f49447efacce672d8f825a4512ba3078p3@CTNND2
3.27e-125FFCP PHASE2:Hg19::chrX:13835398..13835429,-#_9f15399e0f9ed893832eb303520e70c5p6@GPM6B
3.27e-125FFCP PHASE1:Hg19::chrX:13835398..13835429,-#_9f15399e0f9ed893832eb303520e70c5p6@GPM6B
2.36e-124FFCP PHASE2:Hg19::chr12:99548496..99548518,-#_03f49537d216115f06b99ddbdf140054p3@ANKS1B
2.36e-124FFCP PHASE1:Hg19::chr12:99548496..99548518,-#_03f49537d216115f06b99ddbdf140054p3@ANKS1B
5.97e-124FFCP PHASE2:Hg19::chr17:42984601..42984636,-#_b53205b76f5c774bfb7aeb9fb18233a3p2@GFAP
5.97e-124FFCP PHASE1:Hg19::chr17:42984601..42984636,-#_b53205b76f5c774bfb7aeb9fb18233a3p2@GFAP
2.48e-123FFCP PHASE1:Hg19::chr2:210526233..210526258,+#_c3280a54e755cd9a0ddccfad651ead5fp9@MAP2
2.48e-123FFCP PHASE2:Hg19::chr2:210526233..210526258,+#_c3280a54e755cd9a0ddccfad651ead5fp9@MAP2
8.32e-123FFCP PHASE1:Hg19::chr3:47933982..47934047,-#_03167ab0b29f9f00843998dc0c255421p3@MAP4
8.32e-123FFCP PHASE2:Hg19::chr3:47933982..47934047,-#_03167ab0b29f9f00843998dc0c255421p3@MAP4
4.09e-122FFCP PHASE1:Hg19::chr12:99548524..99548550,-#_4a07b3d381884af738b282b040d0d3c0p2@ANKS1B
4.09e-122FFCP PHASE2:Hg19::chr12:99548524..99548550,-#_4a07b3d381884af738b282b040d0d3c0p2@ANKS1B
9.11e-122FFCP PHASE2:Hg19::chr5:87980761..87980821,-#_f32994b64cdd95e36a70ee4168b95c66p4@LINC00461
9.11e-122FFCP PHASE1:Hg19::chr5:87980761..87980821,-#_f32994b64cdd95e36a70ee4168b95c66p4@LINC00461
3.66e-121FFCP PHASE2:Hg19::chr5:87980633..87980649,-#_ff18307dc611f6491280625537007dd2p5@LINC00461
3.66e-121FFCP PHASE1:Hg19::chr5:87980633..87980649,-#_ff18307dc611f6491280625537007dd2p5@LINC00461
4.65e-121FFCP PHASE2:Hg19::chr17:42988700..42988738,-#_c4820e59e1870cb029353e28de3debd8p3@GFAP
4.65e-121FFCP PHASE1:Hg19::chr17:42988700..42988738,-#_c4820e59e1870cb029353e28de3debd8p3@GFAP
5.11e-121FFCP PHASE1:Hg19::chr1:84630574..84630602,+#_0467c273b5e68543a91044cc072d359ep9@PRKACB
5.11e-121FFCP PHASE2:Hg19::chr1:84630574..84630602,+#_0467c273b5e68543a91044cc072d359ep9@PRKACB
7.55e-121FFCP PHASE2:Hg19::chr17:54230819..54230848,+#_293229dfef8374ad6cb7d7eaec66f526p1@ANKFN1
7.55e-121FFCP PHASE1:Hg19::chr17:54230819..54230848,+#_293229dfef8374ad6cb7d7eaec66f526p1@ANKFN1
1.62e-120FFCP PHASE2:Hg19::chr2:210444267..210444287,+#_4013e49e378c5d6df594ae5eb07845ffp7@MAP2
1.62e-120FFCP PHASE1:Hg19::chr2:210444267..210444287,+#_4013e49e378c5d6df594ae5eb07845ffp7@MAP2
3.64e-120FFCP PHASE1:Hg19::chr5:87437585..87437647,+#_8aa6204b3ed8187d9f9f09353ae8867dp@chr5:87437585..87437647, +
3.64e-120FFCP PHASE2:Hg19::chr5:87437585..87437647,+#_8aa6204b3ed8187d9f9f09353ae8867dp@chr5:87437585..87437647, +
4.76e-120FFCP PHASE2:Hg19::chr11:35441089..35441112,-#_24613cfccfb388b03d7c8ede71eb9d75p1@SLC1A2
4.76e-120FFCP PHASE1:Hg19::chr11:35441089..35441112,-#_24613cfccfb388b03d7c8ede71eb9d75p1@SLC1A2
9.92e-120FFCP PHASE2:Hg19::chr4:176733425..176733439,-#_7760ffa04ff23cbdccbc80fc34d505aep8@GPM6A
9.92e-120FFCP PHASE1:Hg19::chr4:176733425..176733439,-#_7760ffa04ff23cbdccbc80fc34d505aep8@GPM6A
1.59e-119FFCP PHASE2:Hg19::chr22:50523760..50523787,-#_19fd1a9886fb7c7e1c4ea7df971193afp4@MLC1
1.59e-119FFCP PHASE1:Hg19::chr22:50523760..50523787,-#_19fd1a9886fb7c7e1c4ea7df971193afp4@MLC1
2.21e-119FFCP PHASE1:Hg19::chr22:18043185..18043204,+#_49f0d40a51f0c9d6daf1f620e24999b1p1@SLC25A18
2.21e-119FFCP PHASE2:Hg19::chr22:18043185..18043204,+#_49f0d40a51f0c9d6daf1f620e24999b1p1@SLC25A18
2.56e-119FFCP PHASE1:Hg19::chr16:72459838..72459857,+#_e95101dd7bce8a434c1eb68291e343f4p1@uc002fch.1
2.56e-119FFCP PHASE2:Hg19::chr16:72459838..72459857,+#_e95101dd7bce8a434c1eb68291e343f4p1@uc002fch.1
1.24e-118FFCP PHASE2:Hg19::chr17:42990725..42990781,-#_c5b7a084268a8d660bedad336af37d56p@chr17:42990725..42990781, -
1.24e-118FFCP PHASE1:Hg19::chr17:42990725..42990781,-#_c5b7a084268a8d660bedad336af37d56p@chr17:42990725..42990781, -
1.31e-118FFCP PHASE2:Hg19::chr4:158141806..158141824,+#_7df9cd2928144f3f1b70c9460595d4f7p4@GRIA2
1.31e-118FFCP PHASE1:Hg19::chr4:158141806..158141824,+#_7df9cd2928144f3f1b70c9460595d4f7p4@GRIA2
1.76e-118FFCP PHASE2:Hg19::chr4:176733632..176733692,-#_1d7d9fce0a09310e658876bffc6f5bdfp9@GPM6A
1.76e-118FFCP PHASE1:Hg19::chr4:176733632..176733692,-#_1d7d9fce0a09310e658876bffc6f5bdfp9@GPM6A
2.49e-118FFCP PHASE1:Hg19::chr17:42991115..42991202,-#_c46d3803a52856c689e942179a956a92p@chr17:42991115..42991202, -
2.49e-118FFCP PHASE2:Hg19::chr17:42991115..42991202,-#_c46d3803a52856c689e942179a956a92p@chr17:42991115..42991202, -
2.72e-118FFCP PHASE2:Hg19::chr12:20848486..20848542,+#_03a24e4e01d7a7eb83defac44feb9d54p1@SLCO1C1
2.72e-118FFCP PHASE1:Hg19::chr12:20848486..20848542,+#_03a24e4e01d7a7eb83defac44feb9d54p1@SLCO1C1
2.84e-118FFCP PHASE1:Hg19::chr11:120255997..120256048,+#_057fed49ee1ea2d72e38004ad51dcf91p3@ARHGEF12
2.84e-118FFCP PHASE2:Hg19::chr11:120255997..120256048,+#_057fed49ee1ea2d72e38004ad51dcf91p3@ARHGEF12
2.93e-118FFCP PHASE2:Hg19::chr2:210526166..210526232,+#_fe0406ce6435f0b96db2cdba8c6e0de7p5@MAP2
2.93e-118FFCP PHASE1:Hg19::chr2:210526166..210526232,+#_fe0406ce6435f0b96db2cdba8c6e0de7p5@MAP2
3.97e-118FFCP PHASE2:Hg19::chr4:176733558..176733609,-#_7cd62f8b61bf3da160115e942bad48e1p7@GPM6A
3.97e-118FFCP PHASE1:Hg19::chr4:176733558..176733609,-#_7cd62f8b61bf3da160115e942bad48e1p7@GPM6A
5.19e-118FFCP PHASE1:Hg19::chr1:84630556..84630571,+#_38ff07a3cb57a8516c8fa2f0d058815cp12@PRKACB
5.19e-118FFCP PHASE2:Hg19::chr1:84630556..84630571,+#_38ff07a3cb57a8516c8fa2f0d058815cp12@PRKACB
5.54e-118FFCP PHASE1:Hg19::chr16:72459772..72459794,+#_2163ae9cab6d52fc8f5e2cf94e27c940p2@uc002fch.1
5.54e-118FFCP PHASE2:Hg19::chr16:72459772..72459794,+#_2163ae9cab6d52fc8f5e2cf94e27c940p2@uc002fch.1
7.23e-118FFCP PHASE1:Hg19::chr6:56716896..56716928,-#_c9cc907a07506d9666e2b1548502b1c1p8@DST
7.23e-118FFCP PHASE2:Hg19::chr6:56716896..56716928,-#_c9cc907a07506d9666e2b1548502b1c1p8@DST
4.0e-117FFCP PHASE2:Hg19::chr11:35440898..35440916,-#_de5cc344ca1f0749467fcce6ca51a54cp2@SLC1A2
4.0e-117FFCP PHASE1:Hg19::chr11:35440898..35440916,-#_de5cc344ca1f0749467fcce6ca51a54cp2@SLC1A2
4.45e-117FFCP PHASE1:Hg19::chr11:35441026..35441037,-#_6557cee1fae916d0c90665099692f376p6@SLC1A2
4.45e-117FFCP PHASE2:Hg19::chr11:35441026..35441037,-#_6557cee1fae916d0c90665099692f376p6@SLC1A2
7.22e-117FFCP PHASE1:Hg19::chr12:106976656..106976672,+#_0021ea38a0165bdfb4f04db431bfcc2cp4@RFX4
7.22e-117FFCP PHASE2:Hg19::chr12:106976656..106976672,+#_0021ea38a0165bdfb4f04db431bfcc2cp4@RFX4
7.65e-117FFCP PHASE2:Hg19::chr6:97753454..97753523,+#_cd378c772b78c47b988ecd6e6e149414p1@uc003ppd.1
7.65e-117FFCP PHASE1:Hg19::chr6:97753454..97753523,+#_cd378c772b78c47b988ecd6e6e149414p1@uc003ppd.1
1.3e-116FFCP PHASE1:Hg19::chr4:57547751..57547764,-#_1898ad09a8637bf3948e4724a9c1a1dfp6@HOPX
1.3e-116FFCP PHASE2:Hg19::chr4:57547751..57547764,-#_1898ad09a8637bf3948e4724a9c1a1dfp6@HOPX
1.44e-116FFCP PHASE1:Hg19::chr5:11904580..11904619,-#_c4310b4f2dd490a174d666c7addd3badp6@CTNND2
1.44e-116FFCP PHASE2:Hg19::chr5:11904580..11904619,-#_c4310b4f2dd490a174d666c7addd3badp6@CTNND2
2.43e-116FFCP PHASE2:Hg19::chr5:112074041..112074101,+#_00312792bc619f72611960a09a29be34p4@APC
2.43e-116FFCP PHASE1:Hg19::chr5:112074041..112074101,+#_00312792bc619f72611960a09a29be34p4@APC
2.57e-116FFCP PHASE2:Hg19::chrX:13835312..13835321,-#_d3861a07e3a7f4a9b2ceba23d0c86dc9p9@GPM6B
2.57e-116FFCP PHASE1:Hg19::chrX:13835312..13835321,-#_d3861a07e3a7f4a9b2ceba23d0c86dc9p9@GPM6B
2.97e-116FFCP PHASE2:Hg19::chr5:149669308..149669323,-#_c2b90829e43872f85fa8a5baeaa7f0fap2@CAMK2A
2.97e-116FFCP PHASE1:Hg19::chr5:149669308..149669323,-#_c2b90829e43872f85fa8a5baeaa7f0fap2@CAMK2A
3.16e-116FFCP PHASE1:Hg19::chr19:10563567..10563617,+#_09acdfcc81fc0cd123dd09475c861c5ap1@PDE4A
3.16e-116FFCP PHASE2:Hg19::chr19:10563567..10563617,+#_09acdfcc81fc0cd123dd09475c861c5ap1@PDE4A
3.88e-116FFCP PHASE2:Hg19::chr16:72459805..72459824,+#_56fe5ed5404938581e1d5806b4c8020fp4@uc002fch.1
3.88e-116FFCP PHASE1:Hg19::chr16:72459805..72459824,+#_56fe5ed5404938581e1d5806b4c8020fp4@uc002fch.1
1.13e-115FFCP PHASE2:Hg19::chr3:47932759..47932803,-#_ac5aa5dbf429c75b7010a005158c2940p12@MAP4
1.13e-115FFCP PHASE1:Hg19::chr3:47932759..47932803,-#_ac5aa5dbf429c75b7010a005158c2940p12@MAP4
2.11e-115FFCP PHASE1:Hg19::chr3:181417353..181417371,+#_40f5129f1491b7d4041db4e1f7eeb63dp1@SOX2-OT
2.11e-115FFCP PHASE2:Hg19::chr3:181417353..181417371,+#_40f5129f1491b7d4041db4e1f7eeb63dp1@SOX2-OT
3.57e-115FFCP PHASE2:Hg19::chr4:176733377..176733424,-#_eb88d6476289280c1a5e0b87c3d7cbecp1@GPM6A
3.57e-115FFCP PHASE1:Hg19::chr4:176733377..176733424,-#_eb88d6476289280c1a5e0b87c3d7cbecp1@GPM6A
6.28e-115FFCP PHASE1:Hg19::chr4:176733927..176733991,-#_252249728b3cd4615ba54ea86d3e8fd5p6@GPM6A
6.28e-115FFCP PHASE2:Hg19::chr4:176733927..176733991,-#_252249728b3cd4615ba54ea86d3e8fd5p6@GPM6A
8.3e-115FFCP PHASE2:Hg19::chr11:35440952..35440970,-#_23fb64adb394877c0b6e1d39bab63bfap3@SLC1A2
8.3e-115FFCP PHASE1:Hg19::chr11:35440952..35440970,-#_23fb64adb394877c0b6e1d39bab63bfap3@SLC1A2
1.06e-114FFCP PHASE1:Hg19::chr2:73286253..73286279,-#_7704c29af2e676afe6287ecedbbd6f5fp3@SFXN5
1.06e-114FFCP PHASE2:Hg19::chr2:73286253..73286279,-#_7704c29af2e676afe6287ecedbbd6f5fp3@SFXN5
1.33e-114FFCP PHASE2:Hg19::chr16:8807419..8807470,+#_d2ddab4bcfc36650233c11b17d03526ep2@ABAT
1.33e-114FFCP PHASE1:Hg19::chr16:8807419..8807470,+#_d2ddab4bcfc36650233c11b17d03526ep2@ABAT

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