Coexpression cluster:C4529: Difference between revisions

Revision as of 13:01, 5 September 2012

Full id: C4529_alveolar_papillary_Meningeal_mesenchymal_Lens_Ciliary_bone

Phase1 CAGE Peaks

Hg19::chr5:92498140..92498169,-	p@chr5:92498140..92498169 -
Hg19::chr5:92498181..92498202,-	p@chr5:92498181..92498202 -
Hg19::chr5:92498209..92498218,-	p@chr5:92498209..92498218 -

Enriched pathways on this co-expression clusterSummary: Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons. Analyst: Emmanuel Dimont link to source dataset data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. Analyst: Erik Arner link to source dataset data

No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji links to source dataset cell_data uberon_data

Cell Type
Ontology term	p-value	n
non-terminally differentiated cell	5.71e-16	180
mesodermal cell	1.29e-12	119
fibroblast	2.04e-11	75
embryonic cell	1.02e-08	248
animal cell	1.22e-07	679
eukaryotic cell	1.22e-07	679
somatic cell	1.47e-07	591
endothelial cell of vascular tree	3.24e-07	24
lining cell	3.32e-07	57
barrier cell	3.32e-07	57
endothelial cell	4.67e-07	35

Uber Anatomy
Ontology term	p-value	n
cell layer	4.77e-14	312
epithelium	1.19e-12	309
organism subdivision	8.83e-12	365
vasculature of head	2.06e-10	11
vasculature of organ	2.06e-10	11
unilaminar epithelium	1.47e-09	138
vasculature	2.35e-09	79
vascular system	2.35e-09	79
cardiovascular system	3.95e-09	110
anatomical cluster	8.08e-09	286
pigment epithelium of eye	1.31e-08	11
circulatory system	1.72e-08	113
somite	8.76e-08	83
paraxial mesoderm	8.76e-08	83
presomitic mesoderm	8.76e-08	83
presumptive segmental plate	8.76e-08	83
trunk paraxial mesoderm	8.76e-08	83
presumptive paraxial mesoderm	8.76e-08	83
trunk mesenchyme	2.35e-07	143

Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon link to source data Novel motifs data Jaspar motifs data

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. Analyst: Erik Arner link to source dataset data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
FOS#2353	3	8.9979553088944	0.00137249927241713	0.00901071482976946
GATA2#2624	3	12.744931733554	0.000482952770428379	0.00438639050271932
JUN#3725	3	12.5128291923363	0.000510331399272625	0.00446012560741705

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. Analyst:NA link to data source data

This analysis result is provided for C0 - C305 clusters.

@@ Line 5: / Line 5: @@
 |ontology_enrichment_disease=
 |ontology_enrichment_uberon=UBERON:0000119!4.77e-14!312;UBERON:0000483!1.19e-12!309;UBERON:0000475!8.83e-12!365;UBERON:0002200!2.06e-10!11;UBERON:0006876!2.06e-10!11;UBERON:0000490!1.47e-09!138;UBERON:0002049!2.35e-09!79;UBERON:0007798!2.35e-09!79;UBERON:0004535!3.95e-09!110;UBERON:0000477!8.08e-09!286;UBERON:0007625!1.31e-08!11;UBERON:0001009!1.72e-08!113;UBERON:0000914!8.76e-08!83;UBERON:0002329!8.76e-08!83;UBERON:0003077!8.76e-08!83;UBERON:0003059!8.76e-08!83;UBERON:0007282!8.76e-08!83;UBERON:0009618!8.76e-08!83;UBERON:0007285!8.76e-08!83;UBERON:0005256!2.35e-07!143
+|tf_chipseq_enrich=FOS#2353;3:8.9979553088944:0.00137249927241713:0.00901071482976946!GATA2#2624;3:12.744931733554:0.000482952770428379:0.00438639050271932!JUN#3725;3:12.5128291923363:0.000510331399272625:0.00446012560741705
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 }}

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Coexpression cluster:C4529: Difference between revisions

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Revision as of 13:01, 5 September 2012

Phase1 CAGE Peaks

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