Coexpression cluster:C1685

Full id: C1685_immature_CD14_Eosinophils_CD34_migratory_lymphoma_Neutrophils

Phase1 CAGE Peaks

Hg19::chr12:72148728..72148739,+	p3@RAB21
Hg19::chr2:61108695..61108753,+	p1@REL
Hg19::chr2:61108771..61108789,+	p4@REL
Hg19::chr2:61108808..61108821,+	p3@REL
Hg19::chr2:61118914..61118929,+	p1@AB464350

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
2.08996656875732e-05	0.0132294883802338	2	131	IL-5 up reg. targets (Netpath):NetPath_17

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.10e-54	140
hematopoietic stem cell	3.33e-48	172
angioblastic mesenchymal cell	3.33e-48	172
hematopoietic oligopotent progenitor cell	2.10e-45	165
hematopoietic multipotent progenitor cell	2.10e-45	165
hematopoietic cell	5.32e-44	182
hematopoietic lineage restricted progenitor cell	2.72e-43	124
nongranular leukocyte	4.04e-42	119
myeloid leukocyte	8.19e-34	76
granulocyte monocyte progenitor cell	1.55e-30	71
myeloid cell	2.50e-29	112
common myeloid progenitor	2.50e-29	112
myeloid lineage restricted progenitor cell	1.22e-27	70
macrophage dendritic cell progenitor	2.69e-27	65
monopoietic cell	5.73e-26	63
monocyte	5.73e-26	63
monoblast	5.73e-26	63
promonocyte	5.73e-26	63
CD14-positive, CD16-negative classical monocyte	2.09e-25	42
classical monocyte	5.06e-25	45
lymphocyte	4.22e-14	53
common lymphoid progenitor	4.22e-14	53
lymphoid lineage restricted progenitor cell	8.86e-14	52
lymphocyte of B lineage	2.68e-08	24
pro-B cell	2.68e-08	24
dendritic cell	1.75e-07	10

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.64e-32	102
blood island	3.64e-32	102
hemolymphoid system	1.21e-31	112
bone marrow	3.52e-24	80
bone element	4.83e-23	86
immune system	1.60e-21	115
skeletal element	1.03e-16	101
skeletal system	1.03e-16	101
adult organism	6.41e-08	115

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	4	5.06896126157011	0.00270999809128077	0.0148923699371361
CTCF#10664	4	4.28820509846002	0.00515201558824328	0.0239259796354013
E2F1#1869	4	3.92591137190346	0.00721498454710636	0.0298709970314454
E2F4#1874	3	7.60083618917066	0.00435414736037571	0.0206476024414402
E2F6#1876	4	4.01372458535791	0.00663211823393388	0.0282899769740982
EGR1#1958	5	4.98817909481014	0.000323739800059071	0.00330541215938697
ETS1#2113	3	5.8372565533214	0.00925327904563143	0.03496899733126
MEF2A#4205	3	11.2459385457864	0.00139936678741195	0.00910128707874682
MYC#4609	4	4.17782549728752	0.00569196903682344	0.0256732262680546
NFKB1#4790	5	5.48806342419384	0.000200816284746232	0.00238873029186921
POU2F2#5452	3	5.46367443464551	0.0111565009446978	0.0410070318210491
REST#5978	3	5.79001722967681	0.00946878869443394	0.0356917321419853
RFX5#5993	3	7.22874649631706	0.0050291827895866	0.0234640527746989
SMARCB1#6598	4	14.6021726249259	4.30486693344344e-05	0.00076814624579173
TAF7#6879	3	6.85984164295435	0.00584328640701904	0.0262412705995296
TCF12#6938	3	6.38067894131185	0.00718516865325884	0.0298267748709289
TFAP2A#7020	3	9.91118062382697	0.00202154697751128	0.0117450125046896
TFAP2C#7022	3	6.48553716591613	0.00685895151794	0.0290569925600185
YY1#7528	4	3.92893659988308	0.00719386626991762	0.0298356047718182

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.