MCL coexpression mm9:762

Phase1 CAGE Peaks

	Short description
Mm9::chr10:42254796..42254825,+	p@chr10:42254796..42254825 +
Mm9::chr11:120440046..120440071,-	p@chr11:120440046..120440071 -
Mm9::chr11:120440419..120440457,-	p@chr11:120440419..120440457 -
Mm9::chr11:120440473..120440512,-	p@chr11:120440473..120440512 -
Mm9::chr11:69808177..69808226,+	p@chr11:69808177..69808226 +
Mm9::chr11:78151313..78151331,+	p@chr11:78151313..78151331 +
Mm9::chr15:102110934..102110960,+	p@chr15:102110934..102110960 +
Mm9::chr5:115939540..115939543,+	p@chr5:115939540..115939543 +
Mm9::chr9:107517351..107517391,-	p@chr9:107517351..107517391 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005094	Rho GDP-dissociation inhibitor activity	0.0158843175808535
GO:0007213	acetylcholine receptor signaling, muscarinic pathway	0.0158843175808535
GO:0005092	GDP-dissociation inhibitor activity	0.0158843175808535
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	0.0285808065411986
GO:0001772	immunological synapse	0.0380910379031665

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	1.02e-10	49
neural cell	1.01e-07	43
ectodermal cell	5.33e-07	44
neurectodermal cell	5.33e-07	44

Uber Anatomy

Ontology term	p-value	n
embryonic structure	5.56e-08	294
developing anatomical structure	6.16e-08	304
germ layer	2.06e-07	291
germ layer / neural crest	2.06e-07	291
embryonic tissue	2.06e-07	291
presumptive structure	2.06e-07	291
germ layer / neural crest derived structure	2.06e-07	291
epiblast (generic)	2.06e-07	291

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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