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Coexpression cluster:C1216

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Full id: C1216_immature_CD14_Natural_Peripheral_Mast_CD34_Basophils



Phase1 CAGE Peaks

Hg19::chr16:11945524..11945538,+p@chr16:11945524..11945538
+
Hg19::chr18:12991627..12991636,-p@chr18:12991627..12991636
-
Hg19::chr19:10514633..10514647,+p@chr19:10514633..10514647
+
Hg19::chr19:10514802..10514824,+p@chr19:10514802..10514824
+
Hg19::chr19:10519743..10519746,+p@chr19:10519743..10519746
+
Hg19::chr1:20987540..20987548,+p@chr1:20987540..20987548
+
Hg19::chr8:81399734..81399738,-p@chr8:81399734..81399738
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.09e-43172
angioblastic mesenchymal cell1.09e-43172
leukocyte1.17e-40140
hematopoietic cell2.23e-40182
hematopoietic oligopotent progenitor cell9.87e-40165
hematopoietic multipotent progenitor cell9.87e-40165
hematopoietic lineage restricted progenitor cell1.73e-32124
nongranular leukocyte5.35e-31119
myeloid cell1.57e-29112
common myeloid progenitor1.57e-29112
myeloid leukocyte7.52e-2676
classical monocyte1.94e-2545
CD14-positive, CD16-negative classical monocyte2.23e-2542
granulocyte monocyte progenitor cell2.66e-2471
myeloid lineage restricted progenitor cell1.67e-2270
macrophage dendritic cell progenitor7.22e-2265
monopoietic cell1.56e-2063
monocyte1.56e-2063
monoblast1.56e-2063
promonocyte1.56e-2063
lymphocyte2.68e-0953
common lymphoid progenitor2.68e-0953
lymphoid lineage restricted progenitor cell3.42e-0952
mesenchymal cell4.43e-08358
intermediate monocyte1.83e-079
CD14-positive, CD16-positive monocyte1.83e-079
connective tissue cell2.28e-07365
motile cell2.94e-07390
Uber Anatomy
Ontology termp-valuen
bone element1.32e-2186
bone marrow2.69e-2180
hematopoietic system5.27e-19102
blood island5.27e-19102
skeletal element2.14e-16101
skeletal system2.14e-16101
hemolymphoid system4.10e-16112
immune system2.21e-14115
connective tissue3.77e-07375


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.