Coexpression cluster:C1197
From FANTOM5_SSTAR
Full id: C1197_hepatoma_Hepatocyte_liver_argyrophil_hepatocellular_gastrointestinal_mesothelioma
Phase1 CAGE Peaks
| Hg19::chr14:23445892..23445897,- | p17@AJUBA |
| Hg19::chr14:23445927..23445936,- | p15@AJUBA |
| Hg19::chr16:52417646..52417654,- | p@chr16:52417646..52417654 - |
| Hg19::chr2:73248062..73248100,- | p21@SFXN5 |
| Hg19::chr5:147209673..147209678,- | p@chr5:147209673..147209678 - |
| Hg19::chr6:50061315..50061323,+ | p1@ENST00000415106 |
| Hg19::chr9:116840728..116840744,- | p2@AMBP |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030568 | plasmin inhibitor activity | 0.00260500985625729 |
| GO:0046904 | calcium oxalate binding | 0.00260500985625729 |
| GO:0019862 | IgA binding | 0.00260500985625729 |
| GO:0019855 | calcium channel inhibitor activity | 0.00260500985625729 |
| GO:0046329 | negative regulation of JNK cascade | 0.00260500985625729 |
| GO:0042167 | heme catabolic process | 0.00260500985625729 |
| GO:0030304 | trypsin inhibitor activity | 0.00260500985625729 |
| GO:0046149 | pigment catabolic process | 0.00260500985625729 |
| GO:0006787 | porphyrin catabolic process | 0.00347324422754211 |
| GO:0033015 | tetrapyrrole catabolic process | 0.00347324422754211 |
| GO:0050777 | negative regulation of immune response | 0.00496141229839008 |
| GO:0002683 | negative regulation of immune system process | 0.00496141229839008 |
| GO:0008200 | ion channel inhibitor activity | 0.00496141229839008 |
| GO:0016248 | channel inhibitor activity | 0.00496141229839008 |
| GO:0005246 | calcium channel regulator activity | 0.0050936416448709 |
| GO:0019865 | immunoglobulin binding | 0.00694536373294039 |
| GO:0046328 | regulation of JNK cascade | 0.00767588960040256 |
| GO:0042168 | heme metabolic process | 0.00767588960040256 |
| GO:0018298 | protein-chromophore linkage | 0.00767588960040256 |
| GO:0051241 | negative regulation of multicellular organismal process | 0.00868055438216479 |
| GO:0006778 | porphyrin metabolic process | 0.00991990324056249 |
| GO:0033013 | tetrapyrrole metabolic process | 0.0108678033134421 |
| GO:0016247 | channel regulator activity | 0.0108678033134421 |
| GO:0042440 | pigment metabolic process | 0.012149734272869 |
| GO:0051187 | cofactor catabolic process | 0.0138837746380827 |
| GO:0019748 | secondary metabolic process | 0.0141501450216093 |
| GO:0006826 | iron ion transport | 0.0146535844609547 |
| GO:0007254 | JNK cascade | 0.01611153515917 |
| GO:0031098 | stress-activated protein kinase signaling pathway | 0.0162732133377396 |
| GO:0007565 | female pregnancy | 0.018734537648372 |
| GO:0050776 | regulation of immune response | 0.0206109159829187 |
| GO:0002682 | regulation of immune system process | 0.0206109159829187 |
| GO:0032403 | protein complex binding | 0.0206109159829187 |
| GO:0000041 | transition metal ion transport | 0.0206109159829187 |
| GO:0009968 | negative regulation of signal transduction | 0.0206109159829187 |
| GO:0046483 | heterocycle metabolic process | 0.0250383882725595 |
| GO:0000165 | MAPKKK cascade | 0.0281013347524844 |
| GO:0042803 | protein homodimerization activity | 0.0288177222531866 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 0.0298515414307917 |
| GO:0006810 | transport | 0.0406471491569161 |
| GO:0015674 | di-, tri-valent inorganic cation transport | 0.0406471491569161 |
| GO:0004866 | endopeptidase inhibitor activity | 0.0406471491569161 |
| GO:0051234 | establishment of localization | 0.0406471491569161 |
| GO:0030414 | protease inhibitor activity | 0.0418333476446704 |
| GO:0051239 | regulation of multicellular organismal process | 0.042588301530179 |
| GO:0020037 | heme binding | 0.0427626175573073 |
| GO:0046906 | tetrapyrrole binding | 0.0427626175573073 |
| GO:0051179 | localization | 0.0427626175573073 |
| GO:0022414 | reproductive process | 0.043047415010481 |
| GO:0051704 | multi-organism process | 0.046040255562797 |
| GO:0051186 | cofactor metabolic process | 0.046486109454568 |
| GO:0042802 | identical protein binding | 0.0477151929368722 |
| GO:0046983 | protein dimerization activity | 0.0477151929368722 |
| GO:0007243 | protein kinase cascade | 0.0481040101179392 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| epithelial cell | 1.56e-10 | 254 |
| metabolising cell | 6.11e-09 | 12 |
| endopolyploid cell | 6.11e-09 | 12 |
| parenchymal cell | 6.11e-09 | 12 |
| polyploid cell | 6.11e-09 | 12 |
| hepatocyte | 6.11e-09 | 12 |
| Ontology term | p-value | n |
|---|---|---|
| carcinoma | 1.19e-13 | 106 |
| cell type cancer | 6.45e-09 | 143 |
| adenocarcinoma | 6.47e-09 | 25 |
| disease of anatomical entity | 3.74e-07 | 39 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| CEBPB#1051 | 4 | 4.55494150047132 | 0.00632108033306846 | 0.0275299127983877 |
| EP300#2033 | 7 | 6.7739417262232 | 1.52695018318475e-06 | 5.86082874610924e-05 |
| FOSL2#2355 | 3 | 7.25580025909787 | 0.00602077509384975 | 0.0269849682442097 |
| FOXA1#3169 | 6 | 9.49835978518753 | 3.4851329158676e-06 | 0.000115881501623781 |
| FOXA2#3170 | 6 | 21.1118260737131 | 3.02035985915038e-08 | 2.04700430454125e-06 |
| HDAC2#3066 | 5 | 9.58258588330447 | 4.24859153994197e-05 | 0.00076005250400822 |
| HNF4A#3172 | 3 | 9.91383872698015 | 0.00247865482166154 | 0.0139228866196692 |
| HNF4G#3174 | 3 | 12.3228953684772 | 0.00132445022199723 | 0.00879254110953275 |
| MAFK#7975 | 3 | 11.6145999162128 | 0.00157162661744092 | 0.00996533982750971 |
| TCF7L2#6934 | 4 | 6.15438660750705 | 0.00206467614813804 | 0.0119709494384827 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
