MCL coexpression mm9:1975

Phase1 CAGE Peaks

	Short description
Mm9::chr11:59104248..59104260,-	p1@Wnt3a
Mm9::chr1:162181568..162181612,-	p@chr1:162181568..162181612 -
Mm9::chr2:25312350..25312370,+	p1@Clic3
Mm9::chr5:23979973..23980002,+	p@chr5:23979973..23980002 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0048342	paraxial mesodermal cell differentiation	0.0106004162834652
GO:0048343	paraxial mesodermal cell fate commitment	0.0106004162834652
GO:0001710	mesodermal cell fate commitment	0.0106004162834652
GO:0048333	mesodermal cell differentiation	0.0106004162834652
GO:0048341	paraxial mesoderm formation	0.0141327267521486
GO:0048103	somatic stem cell division	0.0141327267521486
GO:0017145	stem cell division	0.0158980107671366
GO:0048340	paraxial mesoderm morphogenesis	0.0158980107671366
GO:0048339	paraxial mesoderm development	0.017661552343417
GO:0001947	heart looping	0.017661552343417
GO:0005247	voltage-gated chloride channel activity	0.017661552343417
GO:0022844	voltage-gated anion channel activity	0.017661552343417
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	0.0217343166641928
GO:0030879	mammary gland development	0.0221988350799632
GO:0001707	mesoderm formation	0.0224331808841688
GO:0048332	mesoderm morphogenesis	0.0224331808841688
GO:0001704	formation of primary germ layer	0.0224331808841688
GO:0001756	somitogenesis	0.0224660190724778
GO:0007368	determination of left/right symmetry	0.0224660190724778
GO:0003007	heart morphogenesis	0.0224660190724778
GO:0009799	determination of symmetry	0.0224660190724778
GO:0009855	determination of bilateral symmetry	0.0224660190724778
GO:0035282	segmentation	0.0257821332254141
GO:0007498	mesoderm development	0.027313195137404
GO:0031404	chloride ion binding	0.027313195137404
GO:0043168	anion binding	0.027313195137404
GO:0042472	inner ear morphogenesis	0.027313195137404
GO:0005254	chloride channel activity	0.027313195137404
GO:0006821	chloride transport	0.027313195137404
GO:0042471	ear morphogenesis	0.027313195137404
GO:0005253	anion channel activity	0.027313195137404
GO:0007369	gastrulation	0.0273401459490074
GO:0048839	inner ear development	0.0297785356500678
GO:0048732	gland development	0.0297785356500678
GO:0048729	tissue morphogenesis	0.0297785356500678
GO:0043583	ear development	0.0297785356500678
GO:0009952	anterior/posterior pattern formation	0.0358181979770001
GO:0045165	cell fate commitment	0.0370956030094531
GO:0008509	anion transmembrane transporter activity	0.0404684219415818
GO:0001701	in utero embryonic development	0.0415773641297031
GO:0016055	Wnt receptor signaling pathway	0.0415773641297031
GO:0015698	inorganic anion transport	0.0468974151382522
GO:0003002	regionalization	0.0468974151382522
GO:0045595	regulation of cell differentiation	0.0468974151382522
GO:0007409	axonogenesis	0.0468974151382522
GO:0048667	neuron morphogenesis during differentiation	0.0468974151382522
GO:0048812	neurite morphogenesis	0.0468974151382522
GO:0006820	anion transport	0.0468974151382522
GO:0022832	voltage-gated channel activity	0.0468974151382522
GO:0005244	voltage-gated ion channel activity	0.0468974151382522
GO:0007507	heart development	0.0468974151382522
GO:0000904	cellular morphogenesis during differentiation	0.0484393228132578
GO:0007423	sensory organ development	0.0484393228132578
GO:0048646	anatomical structure formation	0.0484393228132578
GO:0031175	neurite development	0.0498474753391753

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
thoracic cavity element	2.95e-09	17
thoracic segment organ	2.95e-09	17
thoracic cavity	2.95e-09	17
thoracic segment of trunk	2.95e-09	17
respiratory primordium	2.95e-09	17
endoderm of foregut	2.95e-09	17
lung	1.82e-08	14
respiratory tube	1.82e-08	14
respiration organ	1.82e-08	14
pair of lungs	1.82e-08	14
lung primordium	1.82e-08	14
lung bud	1.82e-08	14
epithelial bud	4.03e-07	17
anatomical space	6.07e-07	57

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}