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Coexpression cluster:C1210

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Full id: C1210_CD14_Mast_immature_Eosinophils_Basophils_Neutrophils_CD34



Phase1 CAGE Peaks

Hg19::chr15:52311403..52311461,+p1@MAPK6
Hg19::chr17:30677160..30677200,+p1@ZNF207
Hg19::chr1:94344686..94344748,-p1@DNTTIP2
Hg19::chr1:94344754..94344768,-p2@DNTTIP2
Hg19::chr2:178129358..178129403,-p5@NFE2L2
Hg19::chr5:131132637..131132648,-p2@FNIP1
Hg19::chr5:133561752..133561791,-p1@PPP2CA
p2@SKP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation0.0370566280032591
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein0.0370566280032591
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein0.0370566280032591
GO:0046426negative regulation of JAK-STAT cascade0.0370566280032591
GO:0033239negative regulation of amine metabolic process0.0370566280032591
GO:0001933negative regulation of protein amino acid phosphorylation0.0370566280032591
GO:0045763negative regulation of amino acid metabolic process0.0370566280032591
GO:0042516regulation of tyrosine phosphorylation of Stat3 protein0.0370566280032591
GO:0046983protein dimerization activity0.0370566280032591
GO:0042503tyrosine phosphorylation of Stat3 protein0.0370566280032591
GO:0042326negative regulation of phosphorylation0.0370566280032591
GO:0042509regulation of tyrosine phosphorylation of STAT protein0.0370566280032591
GO:0045936negative regulation of phosphate metabolic process0.0370566280032591
GO:0046425regulation of JAK-STAT cascade0.039697686838835
GO:0007260tyrosine phosphorylation of STAT protein0.0416733700027195
GO:0000188inactivation of MAPK activity0.0416733700027195



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
leukocyte9.54e-34140
myeloid leukocyte1.76e-3376
granulocyte monocyte progenitor cell2.77e-3071
myeloid lineage restricted progenitor cell3.00e-2970
hematopoietic stem cell1.05e-28172
angioblastic mesenchymal cell1.05e-28172
macrophage dendritic cell progenitor2.29e-2765
hematopoietic lineage restricted progenitor cell4.99e-27124
classical monocyte9.59e-2745
CD14-positive, CD16-negative classical monocyte1.33e-2642
hematopoietic oligopotent progenitor cell2.13e-26165
hematopoietic multipotent progenitor cell2.13e-26165
monopoietic cell3.45e-2663
monocyte3.45e-2663
monoblast3.45e-2663
promonocyte3.45e-2663
myeloid cell3.81e-26112
common myeloid progenitor3.81e-26112
hematopoietic cell1.59e-25182
nongranular leukocyte1.13e-24119
mesenchymal cell2.42e-10358
motile cell1.42e-09390
connective tissue cell2.60e-09365
Uber Anatomy
Ontology termp-valuen
bone marrow3.32e-2580
bone element3.63e-2586
skeletal element8.40e-22101
skeletal system8.40e-22101
hematopoietic system1.56e-21102
blood island1.56e-21102
hemolymphoid system4.93e-16112
immune system4.27e-14115
connective tissue7.10e-09375
Disease
Ontology termp-valuen
carcinoma2.08e-08106
cell type cancer4.04e-07143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467516.04512466143483.40064550879441e-060.000113469653767725
BHLHE40#8553212.82051815627930.009678410183733830.0364201009288383
BRCA1#672411.53384608184210.0001867121495693760.00225956317368205
CCNT2#90565.431029923110839.35028339706757e-050.00135837285812539
CHD2#110657.38858773865490.0001498689600820670.00193236596568037
E2F1#186964.206333612753710.0004135232017007640.00393763217199363
E2F4#187447.238891608733970.001117741430524870.00766586533113914
E2F6#187653.583682665498130.004598101897827240.0217255322162133
EGR1#195853.562985067721530.004722351211058930.0222592245399551
ELF1#199763.649798250406460.0009377479782620690.00679036685167525
ETS1#211345.559291955544190.003022564475303460.0160501124281177
GTF2B#2959313.69021282899610.0009761963170245720.00701575606618011
GTF2F1#296235.459854661467560.0132988216841570.0470260923606458
HEY1#2346274.040111043105715.68979821988558e-050.000950170828728223
HMGN3#932444.673455841914620.005751881099938870.0259087686619734
IRF1#365977.63716375356396.59398174986938e-072.98771739685296e-05
JUND#372754.996188529907880.0009734308600070920.00699684415611017
MAX#414954.608968220719370.001424337014033610.0091796564892722
MEF2A#420538.032813246990310.004516397834675020.0213539804181097
MXI1#460157.115408306256640.0001797256225248230.00217930619887031
MYC#460953.730201336863860.003821944222306690.0188701381663825
NFKB1#479064.704054363594720.000216115061401970.00247731762679841
NR3C1#290836.417009999074160.008497228015651550.0324321893332833
NRF1#489946.977302541549090.00128531428862220.00861929748230472
POLR2A#543072.147453176558070.004747636447610280.022340094748906
REST#597868.271453185252597.89289295030691e-060.000222790769415433
SIN3A#2594264.636186908698690.0002351678146357830.00256562116293184
SIX5#14791237.322878009482430.00586667625269160.0263315914373139
SP1#666754.070272412957780.002549206128991580.0141104801200844
SRF#672235.913076398071920.01066868130167450.0393928374214455
TAF1#687273.343046285745290.0002142336319622450.00246603618301609
TAF7#687969.799773775649072.89681485118392e-069.9487157593817e-05
TBP#690873.706770687096390.0001039672097505110.00145105324323582
TCF7L2#693446.154386607507050.002064676148138040.0119716140481561
USF2#739235.568084593601250.01259853435761050.0455554592588888
YY1#752864.209574928446160.000411683378865750.00392261658656692
ZBTB7A#5134144.201091033071940.00849410661287350.0324285714483804
ZEB1#693537.237899436090220.00606280792035710.0268325110769631



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.