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Coexpression cluster:C3135

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Full id: C3135_Hepatocyte_ductus_serous_liver_seminal_kidney_epididymis



Phase1 CAGE Peaks

Hg19::chr11:2397418..2397443,+p6@CD81
Hg19::chr11:2397485..2397493,+p22@CD81
Hg19::chr11:2397520..2397532,+p18@CD81


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
metabolising cell5.31e-1012
endopolyploid cell5.31e-1012
parenchymal cell5.31e-1012
polyploid cell5.31e-1012
hepatocyte5.31e-1012
serous secreting cell8.78e-091
Uber Anatomy
Ontology termp-valuen
male genital duct4.51e-233
internal male genitalia4.51e-233
duct of male reproductive system1.87e-174
abdomen element7.79e-1254
abdominal segment element7.79e-1254
hepatic diverticulum1.69e-1122
liver primordium1.69e-1122
digestive tract diverticulum5.64e-1123
male reproductive organ7.64e-1111
abdominal segment of trunk1.75e-1060
abdomen1.75e-1060
epithelial sac4.69e-1025
epithelium of foregut-midgut junction4.69e-1025
anatomical boundary4.69e-1025
hepatobiliary system4.69e-1025
foregut-midgut junction4.69e-1025
septum transversum4.69e-1025
trunk region element1.05e-09101
sac1.20e-0926
liver1.46e-0919
digestive gland1.46e-0919
liver bud1.46e-0919
immaterial anatomical entity1.96e-09117
vas deferens5.59e-091
spermatic cord5.59e-091
seminal vesicle8.15e-091
seminal fluid secreting gland8.15e-091
epithelium of female gonad8.78e-091
epididymis9.46e-091
reproductive organ1.72e-0848
reproductive structure1.82e-0859
reproductive system1.82e-0859
uterus or analog1.84e-081
male organism4.32e-0822
male reproductive system4.32e-0822
cavitated compound organ7.56e-0831
gut epithelium1.84e-0754
internal genitalia3.97e-0725
adult organism6.75e-07114
kidney8.56e-0726
kidney mesenchyme8.56e-0726
upper urinary tract8.56e-0726
kidney rudiment8.56e-0726
kidney field8.56e-0726
Disease
Ontology termp-valuen
ovary epithelial cancer8.78e-091


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.