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Coexpression cluster:C3320

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Full id: C3320_lymphoma_CD19_CD4_myeloma_Burkitt_CD8_hereditary



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0001608nucleotide receptor activity, G-protein coupled0.00647592134699164
GO:0045028purinergic nucleotide receptor activity, G-protein coupled0.00647592134699164
GO:0016502nucleotide receptor activity0.00647592134699164
GO:0001614purinergic nucleotide receptor activity0.00647592134699164



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
lymphocyte2.70e-4653
common lymphoid progenitor2.70e-4653
lymphoid lineage restricted progenitor cell4.69e-4552
nucleate cell4.97e-4455
leukocyte5.24e-29136
nongranular leukocyte1.61e-27115
lymphocyte of B lineage1.34e-2524
pro-B cell1.34e-2524
mature alpha-beta T cell1.28e-2318
alpha-beta T cell1.28e-2318
immature T cell1.28e-2318
mature T cell1.28e-2318
immature alpha-beta T cell1.28e-2318
hematopoietic lineage restricted progenitor cell7.84e-21120
hematopoietic stem cell1.55e-20168
angioblastic mesenchymal cell1.55e-20168
B cell6.60e-1914
hematopoietic cell1.69e-18177
hematopoietic oligopotent progenitor cell2.00e-18161
hematopoietic multipotent progenitor cell2.00e-18161
CD8-positive, alpha-beta T cell1.48e-1711
T cell5.09e-1725
pro-T cell5.09e-1725
CD4-positive, alpha-beta T cell1.93e-096
granulocyte9.64e-088
Uber Anatomy
Ontology termp-valuen
adult organism7.03e-14114
blood2.85e-1315
haemolymphatic fluid2.85e-1315
organism substance2.85e-1315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335328.36945510360714.37778126761649e-050.000777041294712098



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.