MCL coexpression mm9:139
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030324 | lung development | 0.00187162462721913 |
| GO:0030323 | respiratory tube development | 0.00187162462721913 |
| GO:0005515 | protein binding | 0.00187162462721913 |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | 0.00417780837550083 |
| GO:0005605 | basal lamina | 0.0118687760175718 |
| GO:0035295 | tube development | 0.0233656378188877 |
| GO:0009953 | dorsal/ventral pattern formation | 0.0233656378188877 |
| GO:0008201 | heparin binding | 0.0339440635180946 |
| GO:0005201 | extracellular matrix structural constituent | 0.0339440635180946 |
| GO:0005604 | basement membrane | 0.0339440635180946 |
| GO:0005539 | glycosaminoglycan binding | 0.0401738399512 |
| GO:0048732 | gland development | 0.0401738399512 |
| GO:0030247 | polysaccharide binding | 0.0418270320754177 |
| GO:0001871 | pattern binding | 0.0418270320754177 |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | 0.0418270320754177 |
| GO:0060043 | regulation of cardiac muscle cell proliferation | 0.0418270320754177 |
| GO:0044420 | extracellular matrix part | 0.0418270320754177 |
| GO:0005007 | fibroblast growth factor receptor activity | 0.0418270320754177 |
| GO:0043022 | ribosome binding | 0.0418270320754177 |
| GO:0021798 | forebrain dorsal/ventral pattern formation | 0.0418270320754177 |
| GO:0031526 | brush border membrane | 0.0418270320754177 |
| GO:0045879 | negative regulation of smoothened signaling pathway | 0.0418270320754177 |
| GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | 0.0418270320754177 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| lung | 2.04e-27 | 14 |
| respiratory tube | 2.04e-27 | 14 |
| respiration organ | 2.04e-27 | 14 |
| pair of lungs | 2.04e-27 | 14 |
| lung primordium | 2.04e-27 | 14 |
| lung bud | 2.04e-27 | 14 |
| epithelial bud | 7.03e-22 | 17 |
| thoracic cavity element | 7.03e-22 | 17 |
| thoracic segment organ | 7.03e-22 | 17 |
| thoracic cavity | 7.03e-22 | 17 |
| thoracic segment of trunk | 7.03e-22 | 17 |
| respiratory primordium | 7.03e-22 | 17 |
| endoderm of foregut | 7.03e-22 | 17 |
| epithelial fold | 5.21e-18 | 20 |
| breast | 5.75e-12 | 6 |
| chest | 5.75e-12 | 6 |
| respiratory tract | 6.58e-07 | 41 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.146739 |
| MA0004.1 | 0.0220952 |
| MA0006.1 | 0.095049 |
| MA0007.1 | 0.423052 |
| MA0009.1 | 0.109275 |
| MA0014.1 | 0.0937995 |
| MA0017.1 | 0.351771 |
| MA0019.1 | 0.0421173 |
| MA0024.1 | 0.0899821 |
| MA0025.1 | 0.241615 |
| MA0027.1 | 1.50773 |
| MA0028.1 | 0.0552863 |
| MA0029.1 | 0.277314 |
| MA0030.1 | 2.04988 |
| MA0031.1 | 2.45813 |
| MA0038.1 | 0.209354 |
| MA0040.1 | 1.21908 |
| MA0041.1 | 0.264528 |
| MA0042.1 | 0.132089 |
| MA0043.1 | 0.15848 |
| MA0046.1 | 3.25074 |
| MA0048.1 | 0.00391057 |
| MA0050.1 | 0.375116 |
| MA0051.1 | 1.40347 |
| MA0052.1 | 0.119003 |
| MA0055.1 | 0.000387204 |
| MA0056.1 | 0 |
| MA0057.1 | 0.70638 |
| MA0058.1 | 0.00583815 |
| MA0059.1 | 0.026304 |
| MA0060.1 | 0.000839638 |
| MA0061.1 | 0.624859 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0760706 |
| MA0067.1 | 0.319057 |
| MA0068.1 | 0.753876 |
| MA0069.1 | 0.761634 |
| MA0070.1 | 0.367208 |
| MA0071.1 | 0.373123 |
| MA0072.1 | 0.110547 |
| MA0073.1 | 24.0327 |
| MA0074.1 | 0.311045 |
| MA0076.1 | 0.0404451 |
| MA0077.1 | 0.330629 |
| MA0078.1 | 0.265458 |
| MA0081.1 | 0.175272 |
| MA0083.1 | 0.158042 |
| MA0084.1 | 0.583888 |
| MA0087.1 | 0.831555 |
| MA0088.1 | 0.0596989 |
| MA0089.1 | 0 |
| MA0090.1 | 2.51811 |
| MA0091.1 | 0.0256196 |
| MA0092.1 | 0.048463 |
| MA0093.1 | 0.00208699 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.0521274 |
| MA0101.1 | 0.842172 |
| MA0103.1 | 0.253715 |
| MA0105.1 | 0.140484 |
| MA0106.1 | 0.27655 |
| MA0107.1 | 3.3105 |
| MA0108.2 | 0.0486077 |
| MA0109.1 | 0 |
| MA0111.1 | 1.15177 |
| MA0113.1 | 0.0956638 |
| MA0114.1 | 0.0408629 |
| MA0115.1 | 0.160031 |
| MA0116.1 | 1.21242 |
| MA0117.1 | 0.863805 |
| MA0119.1 | 0.615103 |
| MA0122.1 | 2.8002 |
| MA0124.1 | 0.280977 |
| MA0125.1 | 1.21832 |
| MA0130.1 | 0 |
| MA0131.1 | 0.0408933 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.179184 |
| MA0136.1 | 0.583402 |
| MA0139.1 | 0.297534 |
| MA0140.1 | 0.0520761 |
| MA0141.1 | 0.102122 |
| MA0142.1 | 0.858979 |
| MA0143.1 | 0.259726 |
| MA0144.1 | 0.0834447 |
| MA0145.1 | 0.845654 |
| MA0146.1 | 1.27011 |
| MA0147.1 | 0.0247091 |
| MA0148.1 | 4.64889 |
| MA0149.1 | 0.161489 |
| MA0062.2 | 0.0353581 |
| MA0035.2 | 0.0542043 |
| MA0039.2 | 4.94126 |
| MA0138.2 | 0.350898 |
| MA0002.2 | 0.425091 |
| MA0137.2 | 0.181869 |
| MA0104.2 | 0.0167779 |
| MA0047.2 | 3.89575 |
| MA0112.2 | 0.0811026 |
| MA0065.2 | 0.298191 |
| MA0150.1 | 0.00304263 |
| MA0151.1 | 0 |
| MA0152.1 | 0.0820114 |
| MA0153.1 | 1.05492 |
| MA0154.1 | 0.178255 |
| MA0155.1 | 3.12988 |
| MA0156.1 | 0.0881033 |
| MA0157.1 | 2.77417 |
| MA0158.1 | 0 |
| MA0159.1 | 0.774902 |
| MA0160.1 | 0.527093 |
| MA0161.1 | 0 |
| MA0162.1 | 0.152493 |
| MA0163.1 | 0.42148 |
| MA0164.1 | 1.62104 |
| MA0080.2 | 0.95554 |
| MA0018.2 | 0.18861 |
| MA0099.2 | 0.340839 |
| MA0079.2 | 2.28158 |
| MA0102.2 | 0.62983 |
| MA0258.1 | 0.111624 |
| MA0259.1 | 0.0855984 |
| MA0442.1 | 0 |
