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MCL coexpression mm9:554

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:79343871..79343908,-p@chr10:79343871..79343908
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Mm9::chr10:79350840..79350867,-p@chr10:79350840..79350867
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Mm9::chr11:87607311..87607330,+p6@Mpo
Mm9::chr11:87607521..87607534,+p2@Mpo
Mm9::chr11:87607708..87607714,+p5@Mpo
Mm9::chr11:87608023..87608038,+p@chr11:87608023..87608038
+
Mm9::chr11:87610847..87610872,-p@chr11:87610847..87610872
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Mm9::chr11:87610875..87610882,-p@chr11:87610875..87610882
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Mm9::chr11:87610927..87610949,-p@chr11:87610927..87610949
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Mm9::chr11:87611085..87611092,+p@chr11:87611085..87611092
+
Mm9::chr11:87611115..87611124,-p@chr11:87611115..87611124
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Mm9::chr11:87614594..87614611,-p1@ENSMUST00000130442
Mm9::chr5:30339681..30339683,+p1@Il6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0045630positive regulation of T-helper 2 cell differentiation0.00613480101361967
GO:0045624positive regulation of T-helper cell differentiation0.00613480101361967
GO:0042832defense response to protozoan0.00613480101361967
GO:0001781neutrophil apoptosis0.00613480101361967
GO:0045079negative regulation of chemokine biosynthetic process0.00613480101361967
GO:0005138interleukin-6 receptor binding0.00613480101361967
GO:0045628regulation of T-helper 2 cell differentiation0.00613480101361967
GO:0001562response to protozoan0.00613480101361967
GO:0045064T-helper 2 cell differentiation0.00613480101361967
GO:0045622regulation of T-helper cell differentiation0.00613480101361967
GO:0001780neutrophil homeostasis0.00613480101361967
GO:0042092T-helper 2 type immune response0.00613480101361967
GO:0042744hydrogen peroxide catabolic process0.00613480101361967
GO:0045073regulation of chemokine biosynthetic process0.00613480101361967
GO:0050755chemokine metabolic process0.00613480101361967
GO:0042033chemokine biosynthetic process0.00613480101361967
GO:0002294CD4-positive, alpha-beta T cell differentiation during immune response0.00613480101361967
GO:0002292T cell differentiation during immune response0.00613480101361967
GO:0042093T-helper cell differentiation0.00613480101361967
GO:0032602chemokine production0.00613480101361967
GO:0002262myeloid cell homeostasis0.00613480101361967
GO:0002285lymphocyte activation during immune response0.00613480101361967
GO:0046888negative regulation of hormone secretion0.00613480101361967
GO:0002293alpha-beta T cell differentiation during immune response0.00613480101361967
GO:0002286T cell activation during immune response0.00613480101361967
GO:0042743hydrogen peroxide metabolic process0.00616201967718473
GO:0002366leukocyte activation during immune response0.00616201967718473
GO:0002263cell activation during immune response0.00616201967718473
GO:0042542response to hydrogen peroxide0.00639006753386264
GO:0042036negative regulation of cytokine biosynthetic process0.00639006753386264
GO:0043367CD4-positive, alpha beta T cell differentiation0.00680214356466494
GO:0051048negative regulation of secretion0.0071884320133554
GO:0006950response to stress0.00863425154760473
GO:0000302response to reactive oxygen species0.00901978866054937
GO:0046883regulation of hormone secretion0.0109513998695545
GO:0046632alpha-beta T cell differentiation0.011179247618428
GO:0017148negative regulation of translation0.0127745320491999
GO:0031327negative regulation of cellular biosynthetic process0.0127745320491999
GO:0001776leukocyte homeostasis0.0127745320491999
GO:0006953acute-phase response0.0129338591337989
GO:0048872homeostasis of number of cells0.0130853885419302
GO:0006800oxygen and reactive oxygen species metabolic process0.0132296772504845
GO:0046631alpha-beta T cell activation0.0137438694796838
GO:0009890negative regulation of biosynthetic process0.0137438694796838
GO:0004601peroxidase activity0.0137438694796838
GO:0016684oxidoreductase activity, acting on peroxide as acceptor0.0137438694796838
GO:0005126hematopoietin/interferon-class (D200-domain) cytokine receptor binding0.0158945490724236
GO:0046879hormone secretion0.0163606389997696
GO:0006979response to oxidative stress0.0175884040074963
GO:0042035regulation of cytokine biosynthetic process0.0191491912821177
GO:0051046regulation of secretion0.0195235944556765
GO:0042089cytokine biosynthetic process0.0216249667282421
GO:0042107cytokine metabolic process0.0216249667282421
GO:0030217T cell differentiation0.0216249667282421
GO:0051248negative regulation of protein metabolic process0.0236636738328768
GO:0002526acute inflammatory response0.0263106368820287
GO:0003001generation of a signal involved in cell-cell signaling0.0288551655400247
GO:0002250adaptive immune response0.0288551655400247
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0288551655400247
GO:0030098lymphocyte differentiation0.0293282650749003
GO:0001816cytokine production0.0310364227731297
GO:0005615extracellular space0.0328634828356414
GO:0020037heme binding0.0331563053314338
GO:0046906tetrapyrrole binding0.0331563053314338
GO:0042110T cell activation0.0346818569534329
GO:0044421extracellular region part0.0346818569534329
GO:0002521leukocyte differentiation0.0362210529925595
GO:0006417regulation of translation0.0368083864733086
GO:0031326regulation of cellular biosynthetic process0.0384817291650034
GO:0008083growth factor activity0.0406497293099706
GO:0045595regulation of cell differentiation0.0411052176127616
GO:0009889regulation of biosynthetic process0.0411052176127616
GO:0051707response to other organism0.0428855709526981
GO:0005764lysosome0.0432619566004032
GO:0000323lytic vacuole0.0432619566004032
GO:0046649lymphocyte activation0.0473162225814055
GO:0005773vacuole0.0473162225814055
GO:0045321leukocyte activation0.049194139494195
GO:0030097hemopoiesis0.049194139494195
GO:0006954inflammatory response0.049194139494195
GO:0009607response to biotic stimulus0.049194139494195
GO:0005125cytokine activity0.0497498975935377



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
femur1.53e-104
hindlimb long bone1.53e-104
upper leg bone1.53e-104
bone of hip region1.53e-104
skeleton of limb1.53e-104
pelvic appendage skeleton1.53e-104
subdivision of skeleton1.53e-104
endochondral bone1.53e-104
bone of free limb or fin1.53e-104
bone of appendage girdle complex1.53e-104
endochondral element1.53e-104
hindlimb mesenchyme1.53e-104
limb bone1.53e-104
bone of pelvic complex1.53e-104
long bone1.53e-104
hindlimb bone1.53e-104
limb long bone1.53e-104
leg bone1.53e-104
limb mesenchyme1.53e-104
limb skeleton subdivision1.53e-104
hindlimb bone pre-cartilage condensation1.53e-104
upper leg mesenchyme1.53e-104
hindlimb cartilage element1.53e-104
limb cartilage element1.53e-104
limb bone pre-cartilage condensation1.53e-104
cartilage element1.53e-104
hindlimb skeleton1.53e-104
appendicular skeletal system1.53e-104
appendicular skeleton1.53e-104
limb of embryo1.53e-104
skeleton1.53e-104
femur cartilage element1.53e-104
femur pre-cartilage condensation1.53e-104
spleen1.08e-096
cavity lining1.08e-096
serous membrane1.08e-096
gastrointestinal system mesentery1.08e-096
stomach region1.08e-096
mesentery1.08e-096
gastrointestinal system serosa1.08e-096
mesentery of stomach1.08e-096
gut mesentery1.08e-096
dorsal mesentery1.08e-096
dorsal mesogastrium1.08e-096
peritoneal cavity1.08e-096
spleen primordium1.08e-096
hindlimb bud2.01e-085
stylopod2.01e-085
lower limb segment2.01e-085
multi-limb segment region2.01e-085
pelvic appendage2.01e-085
limb segment2.01e-085
paired limb/fin segment2.01e-085
pelvic appendage bud2.01e-085
subdivision of organism along appendicular axis2.01e-085
leg2.01e-085
hindlimb2.01e-085
hindlimb stylopod2.01e-085
posterior region of body2.01e-085
pelvic complex2.01e-085
hindlimb/pelvic fin field2.01e-085
intraembryonic coelom4.36e-0810
abdomen element9.63e-0849
abdominal segment element9.63e-0849
abdominal segment of trunk9.63e-0849
abdomen9.63e-0849
liver2.40e-0722
epithelial sac2.40e-0722
digestive gland2.40e-0722
epithelium of foregut-midgut junction2.40e-0722
anatomical boundary2.40e-0722
hepatobiliary system2.40e-0722
foregut-midgut junction2.40e-0722
hepatic diverticulum2.40e-0722
liver primordium2.40e-0722
septum transversum2.40e-0722
liver bud2.40e-0722
subdivision of skeletal system5.21e-076
developing mesenchymal condensation5.21e-076
pre-cartilage condensation5.21e-076
cartilaginous condensation5.21e-076
digestive tract diverticulum5.87e-0723
sac5.87e-0723


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0157697
MA0004.10.279808
MA0006.10.14766
MA0007.10.267314
MA0009.10.678286
MA0014.10.166639
MA0017.11.53792
MA0019.10.506787
MA0024.10.636635
MA0025.10.9035
MA0027.12.3071
MA0028.10.155127
MA0029.10.616052
MA0030.10.622264
MA0031.10.588678
MA0038.10.405578
MA0040.10.690239
MA0041.10.622762
MA0042.10.207696
MA0043.10.771094
MA0046.10.712646
MA0048.10.602366
MA0050.10.312673
MA0051.10.413609
MA0052.10.697946
MA0055.10.183408
MA0056.10
MA0057.10.302463
MA0058.10.202403
MA0059.10.608499
MA0060.10.0941959
MA0061.10.113212
MA0063.10
MA0066.10.395746
MA0067.11.01206
MA0068.10.0328198
MA0069.10.698271
MA0070.10.688999
MA0071.10.311956
MA0072.10.680902
MA0073.10.0105271
MA0074.11.70003
MA0076.10.181159
MA0077.10.660245
MA0078.11.97224
MA0081.11.21585
MA0083.10.77033
MA0084.11.33532
MA0087.10.728855
MA0088.10.204026
MA0089.10
MA0090.10.251458
MA0091.12.20385
MA0092.10.251716
MA0093.10.161141
MA0095.10
MA0098.10
MA0100.10.931999
MA0101.10.219061
MA0103.10.174916
MA0105.10.434904
MA0106.10.450539
MA0107.10.170338
MA0108.21.30903
MA0109.10
MA0111.10.263095
MA0113.10.424958
MA0114.10.727901
MA0115.10.773793
MA0116.10.147513
MA0117.10.742722
MA0119.10.219527
MA0122.10.761823
MA0124.10.959967
MA0125.10.887718
MA0130.10
MA0131.10.502588
MA0132.10
MA0133.10
MA0135.10.806261
MA0136.11.76101
MA0139.10.0756871
MA0140.10.931776
MA0141.10.18979
MA0142.10.575041
MA0143.15.09722
MA0144.10.365041
MA0145.10.698105
MA0146.10.00215921
MA0147.10.121834
MA0148.10.293462
MA0149.10.223436
MA0062.20.0556611
MA0035.20.357786
MA0039.20.0150018
MA0138.20.495254
MA0002.20.266731
MA0137.20.187581
MA0104.20.0856657
MA0047.20.404891
MA0112.21.02934
MA0065.21.85775
MA0150.10.267221
MA0151.10
MA0152.10.404987
MA0153.10.822355
MA0154.10.139881
MA0155.10.484422
MA0156.11.02086
MA0157.10.545026
MA0158.10
MA0159.10.803691
MA0160.10.296006
MA0161.10
MA0162.10.0186388
MA0163.10.232458
MA0164.10.381832
MA0080.21.56168
MA0018.20.390455
MA0099.20.489441
MA0079.20.0905512
MA0102.21.38728
MA0258.11.1381
MA0259.10.114734
MA0442.10
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