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CL:0000576

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Name:monocyte
Namespace:FANTOM
Definition:"Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, http://www.clt.astate.edu/wwilliam/, MESH:A.11.118.637.555.652]
Xrefs:
links:

BTO:0000876

FMA:62864
Comments:Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0000766(myeloid leukocyte),CL:0002087(nongranular leukocyte)
develops_from:CL:0000559(promonocyte)



Children


is a:CL:0000860 (classical monocyte),CL:0000875 (non-classical monocyte),CL:0001054 (CD14-positive monocyte),CL:0002393 (intermediate monocyte),FF:11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1),FF:11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2),FF:11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
derives from:FF:0000024 (human CD14-positive monocyte sample),FF:0000044 (human monocyte immature derived dendritic cell sample),FF:0000566 (human Monocyte-derived macrophages 0min after LPS treatment sample),FF:0000567 (human Monocyte-derived macrophages 15min after LPS treatment sample),FF:0000568 (human Monocyte-derived macrophages 30min after LPS treatment sample),FF:0000569 (human Monocyte-derived macrophages 45min after LPS treatment sample),FF:0000570 (human Monocyte-derived macrophages 1h after LPS treatment sample),FF:0000571 (human Monocyte-derived macrophages 80min after LPS treatment sample),FF:0000572 (human Monocyte-derived macrophages 100min after LPS treatment sample),FF:0000573 (human Monocyte-derived macrophages 2h after LPS treatment sample),FF:0000574 (human Monocyte-derived macrophages 2.5h after LPS treatment sample),FF:0000575 (human Monocyte-derived macrophages 3h after LPS treatment sample),FF:0000576 (human Monocyte-derived macrophages 3.5h after LPS treatment sample),FF:0000577 (human Monocyte-derived macrophages 4h after LPS treatment sample),FF:0000578 (human Monocyte-derived macrophages 5h after LPS treatment sample),FF:0000579 (human Monocyte-derived macrophages 6h after LPS treatment sample),FF:0000580 (human Monocyte-derived macrophages 7h after LPS treatment sample),FF:0000581 (human Monocyte-derived macrophages 8h after LPS treatment sample),FF:0000582 (human Monocyte-derived macrophages 10h after LPS treatment sample),FF:0000583 (human Monocyte-derived macrophages 12h after LPS treatment sample),FF:0000584 (human Monocyte-derived macrophages 14h after LPS treatment sample),FF:0000585 (human Monocyte-derived macrophages 16h after LPS treatment sample),FF:0000586 (human Monocyte-derived macrophages 18h after LPS treatment sample),FF:0000587 (human Monocyte-derived macrophages 20h after LPS treatment sample),FF:0000588 (human Monocyte-derived macrophages 22h after LPS treatment sample),FF:0000589 (human Monocyte-derived macrophages 24h after LPS treatment sample),FF:0000590 (human Monocyte-derived macrophages 36h after LPS treatment sample),FF:0000591 (human Monocyte-derived macrophages 48h after LPS treatment sample),FF:0102332 (monocytic leukemia cell line sample)
develops from:CL:0000092 (osteoclast),CL:0000235 (macrophage)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

  • 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
  • 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
  • 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
  • 11224-116B9 (CD14+ Monocytes, donor1)
  • 11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1)
  • 11305-117B9 (CD14+ Monocytes, donor2)
  • 11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2)
  • 11381-118B4 (CD14+ Monocytes, donor3)
  • 11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
  • 11788-124B6 (CD14+CD16- Monocytes, donor1)

... further results Mouse (Mus musculus)

  • 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
  • 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
  • 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
  • 11224-116B9 (CD14+ Monocytes, donor1)
  • 11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1)
  • 11305-117B9 (CD14+ Monocytes, donor2)
  • 11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2)
  • 11381-118B4 (CD14+ Monocytes, donor3)
  • 11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
  • 11788-124B6 (CD14+CD16- Monocytes, donor1)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000576 (monocyte), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
1.04e-147FFCP PHASE1:Hg19::chr7:77050554..77050601,+#_e841a3432f111d994e7bd455bb1c50d5p@chr7:77050554..77050601, +
1.04e-147FFCP PHASE2:Hg19::chr7:77050554..77050601,+#_e841a3432f111d994e7bd455bb1c50d5p@chr7:77050554..77050601, +
5.64e-145FFCP PHASE2:Hg19::chr19:18288651..18288682,+#_4916a9b9c0704da6809ebd7b85d81244p5@IFI30
5.64e-145FFCP PHASE1:Hg19::chr19:18288651..18288682,+#_4916a9b9c0704da6809ebd7b85d81244p5@IFI30
4.95e-140FFCP PHASE1:Hg19::chr19:18288828..18288861,+#_4e870d264e07d1512a0c6f103b9d3844p7@IFI30
4.95e-140FFCP PHASE2:Hg19::chr19:18288828..18288861,+#_4e870d264e07d1512a0c6f103b9d3844p7@IFI30
5.06e-140FFCP PHASE2:Hg19::chr5:180242646..180242657,-#_3405d626826116e9d7a2ad94f72e3851p15@MGAT1
5.06e-140FFCP PHASE1:Hg19::chr5:180242646..180242657,-#_3405d626826116e9d7a2ad94f72e3851p15@MGAT1
1.31e-139FFCP PHASE2:Hg19::chr1:161188661..161188679,+#_975dc5c42ca402aa5a8b85edc73f16d7p@chr1:161188661..161188679, +
1.31e-139FFCP PHASE1:Hg19::chr1:161188661..161188679,+#_975dc5c42ca402aa5a8b85edc73f16d7p@chr1:161188661..161188679, +
5.87e-136FFCP PHASE1:Hg19::chr2:38358217..38358244,+#_ac1b976c6aed95772a8b56e4e7465181p1@CYP1B1-AS1
5.87e-136FFCP PHASE2:Hg19::chr2:38358217..38358244,+#_ac1b976c6aed95772a8b56e4e7465181p1@CYP1B1-AS1
5.37e-135FFCP PHASE2:Hg19::chr4:185314125..185314143,-#_b468b272878570395920f3a5fd5b2d3ap@chr4:185314125..185314143, -
5.37e-135FFCP PHASE1:Hg19::chr4:185314125..185314143,-#_b468b272878570395920f3a5fd5b2d3ap@chr4:185314125..185314143, -
3.75e-134FFCP PHASE1:Hg19::chr3:149531627..149531651,+#_49b2d9a7d7054ddb1747f92ab2934413p7@RNF13
3.75e-134FFCP PHASE2:Hg19::chr3:149531627..149531651,+#_49b2d9a7d7054ddb1747f92ab2934413p7@RNF13
6.15e-134FFCP PHASE1:Hg19::chr2:119726719..119726744,+#_dc4daa3781e106c1d0f81085af439047p@chr2:119726719..119726744, +
6.15e-134FFCP PHASE2:Hg19::chr2:119726719..119726744,+#_dc4daa3781e106c1d0f81085af439047p@chr2:119726719..119726744, +
7.41e-134FFCP PHASE2:Hg19::chr1:161187824..161187847,+#_a0022696b9fbe8374086cbdd391e1028p@chr1:161187824..161187847, +
7.41e-134FFCP PHASE1:Hg19::chr1:161187824..161187847,+#_a0022696b9fbe8374086cbdd391e1028p@chr1:161187824..161187847, +
2.24e-133FFCP PHASE1:Hg19::chr17:7482481..7482508,-#_081613de6d26b4a983a0135a61a42d5ep@chr17:7482481..7482508, -
2.24e-133FFCP PHASE2:Hg19::chr17:7482481..7482508,-#_081613de6d26b4a983a0135a61a42d5ep@chr17:7482481..7482508, -
4.55e-133FFCP PHASE2:Hg19::chr19:18286116..18286156,+#_661d2739e36b9cf63f8d0dcfac6a6c65p@chr19:18286116..18286156, +
4.55e-133FFCP PHASE1:Hg19::chr19:18286116..18286156,+#_661d2739e36b9cf63f8d0dcfac6a6c65p@chr19:18286116..18286156, +
1.09e-132FFCP PHASE2:Hg19::chr4:185314151..185314178,-#_07cf5422569fa9c7280df55a0ae98a7fp@chr4:185314151..185314178, -
1.09e-132FFCP PHASE1:Hg19::chr4:185314151..185314178,-#_07cf5422569fa9c7280df55a0ae98a7fp@chr4:185314151..185314178, -
1.13e-132FFCP PHASE1:Hg19::chr5:131280548..131280574,-#_5c2516a21088a63bed730718ab182e46p1@ENST00000425320
1.13e-132FFCP PHASE2:Hg19::chr5:131280548..131280574,-#_5c2516a21088a63bed730718ab182e46p1@ENST00000425320
1.42e-132FFCP PHASE2:Hg19::chr2:145429606..145429658,+#_d1c446d9e222e70e32838b68a7130ae3p@chr2:145429606..145429658, +
1.42e-132FFCP PHASE1:Hg19::chr2:145429606..145429658,+#_d1c446d9e222e70e32838b68a7130ae3p@chr2:145429606..145429658, +
1.21e-131FFCP PHASE1:Hg19::chr19:18288064..18288080,+#_9f4c7048da34267cdafd81c0996cf60ap@chr19:18288064..18288080, +
1.21e-131FFCP PHASE2:Hg19::chr19:18288064..18288080,+#_9f4c7048da34267cdafd81c0996cf60ap@chr19:18288064..18288080, +
2.27e-131FFCP PHASE2:Hg19::chr1:150724282..150724308,-#_5ac5784d98730952a6bd28b477d07974p8@CTSS
2.27e-131FFCP PHASE1:Hg19::chr1:150724282..150724308,-#_5ac5784d98730952a6bd28b477d07974p8@CTSS
2.82e-131FFCP PHASE1:Hg19::chrX:37664331..37664352,+#_84939333c35ee1388737badb2a88e718p@chrX:37664331..37664352, +
2.82e-131FFCP PHASE2:Hg19::chrX:37664331..37664352,+#_84939333c35ee1388737badb2a88e718p@chrX:37664331..37664352, +
4.07e-131FFCP PHASE1:Hg19::chr4:185314188..185314207,-#_e2ee5799beac351b10c0e5af799123d5p@chr4:185314188..185314207, -
4.07e-131FFCP PHASE2:Hg19::chr4:185314188..185314207,-#_e2ee5799beac351b10c0e5af799123d5p@chr4:185314188..185314207, -
5.24e-131FFCP PHASE2:Hg19::chr15:65174546..65174583,-#_3e621801ab04b9722e3928a656c940a4p@chr15:65174546..65174583, -
5.24e-131FFCP PHASE1:Hg19::chr15:65174546..65174583,-#_3e621801ab04b9722e3928a656c940a4p@chr15:65174546..65174583, -
2.76e-130FFCP PHASE2:Hg19::chr4:159727272..159727307,+#_5e3c44e2014780eb1b0c222bb3660ec1p7@FNIP2
2.76e-130FFCP PHASE1:Hg19::chr4:159727272..159727307,+#_5e3c44e2014780eb1b0c222bb3660ec1p7@FNIP2
3.58e-130FFCP PHASE1:Hg19::chr1:161188746..161188758,+#_0a1780f6da603de717a7e850d0ef9eadp@chr1:161188746..161188758, +
3.58e-130FFCP PHASE2:Hg19::chr1:161188746..161188758,+#_0a1780f6da603de717a7e850d0ef9eadp@chr1:161188746..161188758, +
2.17e-129FFCP PHASE2:Hg19::chr20:1517991..1518011,-#_ed73f72f8f6193ea95552dd0f2278128p@chr20:1517991..1518011, -
2.17e-129FFCP PHASE1:Hg19::chr20:1517991..1518011,-#_ed73f72f8f6193ea95552dd0f2278128p@chr20:1517991..1518011, -
3.46e-129FFCP PHASE2:Hg19::chr18:2847062..2847071,+#_3315df1f42f49b07d7a6d14932675cf6p7@EMILIN2
3.46e-129FFCP PHASE1:Hg19::chr18:2847062..2847071,+#_3315df1f42f49b07d7a6d14932675cf6p7@EMILIN2
1.47e-128FFCP PHASE1:Hg19::chr19:18288514..18288554,+#_5cc219cf1e8ebfe46eea88c60102da7cp6@IFI30
1.47e-128FFCP PHASE2:Hg19::chr19:18288514..18288554,+#_5cc219cf1e8ebfe46eea88c60102da7cp6@IFI30
1.78e-128FFCP PHASE2:Hg19::chr19:18288914..18288931,-#_8020898b0d897b8050e9dbe1fcf3f980p5@CU676849, p5@CU689079
1.78e-128FFCP PHASE1:Hg19::chr19:18288914..18288931,-#_8020898b0d897b8050e9dbe1fcf3f980p5@CU676849, p5@CU689079
2.01e-128FFCP PHASE2:Hg19::chr5:180242576..180242585,-#_9dd64fdae37d93929d661a5f9eff1e1dp12@MGAT1
2.01e-128FFCP PHASE1:Hg19::chr5:180242576..180242585,-#_9dd64fdae37d93929d661a5f9eff1e1dp12@MGAT1
2.32e-127FFCP PHASE1:Hg19::chr17:40168698..40168726,-#_3f2620f5c9e56d754afd26e3c4827d02p1@AK126179
2.32e-127FFCP PHASE2:Hg19::chr17:40168698..40168726,-#_3f2620f5c9e56d754afd26e3c4827d02p1@AK126179
2.49e-127FFCP PHASE2:Hg19::chr17:7483714..7483726,+#_c945b31e2eb3132953fb90433bb45ce9p@chr17:7483714..7483726, +
2.49e-127FFCP PHASE1:Hg19::chr17:7483714..7483726,+#_c945b31e2eb3132953fb90433bb45ce9p@chr17:7483714..7483726, +
1.19e-126FFCP PHASE1:Hg19::chr22:46998103..46998127,-#_f7b204f17ca4c68e13f25a4e6ad941dbp@chr22:46998103..46998127, -
1.19e-126FFCP PHASE2:Hg19::chr22:46998103..46998127,-#_f7b204f17ca4c68e13f25a4e6ad941dbp@chr22:46998103..46998127, -
2.16e-126FFCP PHASE2:Hg19::chr19:18285955..18285972,+#_3f71b355ac70ebde7217920f15cce7dep@chr19:18285955..18285972, +
2.16e-126FFCP PHASE1:Hg19::chr19:18285955..18285972,+#_3f71b355ac70ebde7217920f15cce7dep@chr19:18285955..18285972, +
3.83e-126FFCP PHASE1:Hg19::chr19:51625924..51625942,+#_6100f824c480533c174ce83d183b2892p@chr19:51625924..51625942, +
3.83e-126FFCP PHASE2:Hg19::chr19:51625924..51625942,+#_6100f824c480533c174ce83d183b2892p@chr19:51625924..51625942, +
7.27e-126FFCP PHASE2:Hg19::chr4:185266972..185267007,+#_30217061e294eb9814d7f98f97b516a8p@chr4:185266972..185267007, +
7.27e-126FFCP PHASE1:Hg19::chr4:185266972..185267007,+#_30217061e294eb9814d7f98f97b516a8p@chr4:185266972..185267007, +
2.66e-125FFCP PHASE2:Hg19::chrX:152086449..152086473,+#_17870b170cb29e36c8d280277d0c859bp4@ZNF185
2.66e-125FFCP PHASE1:Hg19::chrX:152086449..152086473,+#_17870b170cb29e36c8d280277d0c859bp4@ZNF185
7.73e-125FFCP PHASE1:Hg19::chr2:145276939..145276960,+#_800526383474788672660c5440a0fe92p2@ZEB2-AS1
7.73e-125FFCP PHASE2:Hg19::chr2:145276939..145276960,+#_800526383474788672660c5440a0fe92p2@ZEB2-AS1
8.12e-125FFCP PHASE2:Hg19::chr15:59469817..59469836,+#_26c2162030fbd71556499818047d2916p@chr15:59469817..59469836, +
8.12e-125FFCP PHASE1:Hg19::chr15:59469817..59469836,+#_26c2162030fbd71556499818047d2916p@chr15:59469817..59469836, +
1.56e-124FFCP PHASE2:Hg19::chr20:1517945..1517963,-#_72a3edb409981b3f5d0a998451d887d9p@chr20:1517945..1517963, -
1.56e-124FFCP PHASE1:Hg19::chr20:1517945..1517963,-#_72a3edb409981b3f5d0a998451d887d9p@chr20:1517945..1517963, -
1.65e-124FFCP PHASE1:Hg19::chr8:116588888..116588904,+#_42552d71e39c9a0ac9456dd061a75e56p@chr8:116588888..116588904, +
1.65e-124FFCP PHASE2:Hg19::chr8:116588888..116588904,+#_42552d71e39c9a0ac9456dd061a75e56p@chr8:116588888..116588904, +
1.87e-124FFCP PHASE2:Hg19::chr1:161188686..161188721,+#_6380f99099a7f98468aed618a40c6a21+, p@chr1:161188686..161188721
1.87e-124FFCP PHASE1:Hg19::chr1:161188686..161188721,+#_6380f99099a7f98468aed618a40c6a21p@chr1:161188686..161188721, +
7.08e-124FFCP PHASE2:Hg19::chr5:77845080..77845099,-#_e6f6a9543cf57aed119f7d2df5a96b3bp10@LHFPL2
7.08e-124FFCP PHASE1:Hg19::chr5:77845080..77845099,-#_e6f6a9543cf57aed119f7d2df5a96b3bp10@LHFPL2
1.48e-123FFCP PHASE2:Hg19::chr9:137264970..137264982,+#_bf843d4008f5bf9d6a74bc52d9427fffp@chr9:137264970..137264982, +
1.48e-123FFCP PHASE1:Hg19::chr9:137264970..137264982,+#_bf843d4008f5bf9d6a74bc52d9427fffp@chr9:137264970..137264982, +
6.01e-123FFCP PHASE2:Hg19::chr17:47294661..47294681,+#_92ffb12b3d87f73acb495beb9acb8f64p@chr17:47294661..47294681, +
6.01e-123FFCP PHASE1:Hg19::chr17:47294661..47294681,+#_92ffb12b3d87f73acb495beb9acb8f64p@chr17:47294661..47294681, +
1.14e-122FFCP PHASE1:Hg19::chr1:108593061..108593077,+#_ed234a5288fbfbca21c2f99d62cf14a3p@chr1:108593061..108593077, +
1.14e-122FFCP PHASE2:Hg19::chr1:108593061..108593077,+#_ed234a5288fbfbca21c2f99d62cf14a3p@chr1:108593061..108593077, +
2.07e-122FFCP PHASE2:Hg19::chrX:153286067..153286101,-#_039ebdc09084b301ef30d4ef6e2903cfp@chrX:153286067..153286101, -
2.07e-122FFCP PHASE1:Hg19::chrX:153286067..153286101,-#_039ebdc09084b301ef30d4ef6e2903cfp@chrX:153286067..153286101, -
3.07e-122FFCP PHASE2:Hg19::chr14:103587759..103587770,+#_9856679a3f38884ddca0316db28a22c5p@chr14:103587759..103587770, +
3.07e-122FFCP PHASE1:Hg19::chr14:103587759..103587770,+#_9856679a3f38884ddca0316db28a22c5p@chr14:103587759..103587770, +
7.82e-122FFCP PHASE1:Hg19::chr1:17945095..17945126,+#_003f551dad7de92870eed6c206c9c85ap7@ARHGEF10L
7.82e-122FFCP PHASE2:Hg19::chr1:17945095..17945126,+#_003f551dad7de92870eed6c206c9c85ap7@ARHGEF10L
3.27e-121FFCP PHASE2:Hg19::chr16:50313426..50313459,+#_3ee52232ca68108bb4a2c2b96e1fbcd1p@chr16:50313426..50313459, +
3.27e-121FFCP PHASE1:Hg19::chr16:50313426..50313459,+#_3ee52232ca68108bb4a2c2b96e1fbcd1p@chr16:50313426..50313459, +
3.74e-121FFCP PHASE1:Hg19::chr10:20105868..20105875,+#_0e5a23faf85f7ce6aa9a9ac43c46fecfp8@PLXDC2
3.74e-121FFCP PHASE2:Hg19::chr10:20105868..20105875,+#_0e5a23faf85f7ce6aa9a9ac43c46fecfp8@PLXDC2
7.36e-121FFCP PHASE2:Hg19::chr1:150705526..150705571,-#_cbe6b5dc2466eda566cfcc2f54c2b409-, p@chr1:150705526..150705571
7.36e-121FFCP PHASE1:Hg19::chr1:150705526..150705571,-#_cbe6b5dc2466eda566cfcc2f54c2b409p@chr1:150705526..150705571, -
1.75e-120FFCP PHASE1:Hg19::chr19:18283959..18283993,+#_cb01dc8c4e4d3b6ef42e2c487297fbaep@chr19:18283959..18283993, +
1.75e-120FFCP PHASE2:Hg19::chr19:18283959..18283993,+#_cb01dc8c4e4d3b6ef42e2c487297fbaep@chr19:18283959..18283993, +