Coexpression cluster:C4271
From FANTOM5_SSTAR
Full id: C4271_cord_migratory_CD14_immature_b_xeroderma_Dendritic
Phase1 CAGE Peaks
Short description | |
---|---|
Hg19::chr3:119278376..119278390,- | p2@CD80 |
Hg19::chr9:114246503..114246515,- | p12@KIAA0368 |
Hg19::chr9:114246521..114246540,- | p5@KIAA0368 |
Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont
link to source dataset
data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner
link to source dataset
data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0045627 | positive regulation of T-helper 1 cell differentiation | 0.00585830455523893 |
GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 0.00585830455523893 |
GO:0045625 | regulation of T-helper 1 cell differentiation | 0.00585830455523893 |
GO:0045624 | positive regulation of T-helper cell differentiation | 0.00585830455523893 |
GO:0045423 | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 0.00585830455523893 |
GO:0045063 | T-helper 1 cell differentiation | 0.00585830455523893 |
GO:0032604 | granulocyte macrophage colony-stimulating factor production | 0.00585830455523893 |
GO:0042253 | granulocyte macrophage colony-stimulating factor biosynthetic process | 0.00585830455523893 |
GO:0045622 | regulation of T-helper cell differentiation | 0.00585830455523893 |
GO:0002294 | CD4-positive, alpha-beta T cell differentiation during immune response | 0.00585830455523893 |
GO:0002292 | T cell differentiation during immune response | 0.00585830455523893 |
GO:0042093 | T-helper cell differentiation | 0.00585830455523893 |
GO:0002366 | leukocyte activation during immune response | 0.00585830455523893 |
GO:0002285 | lymphocyte activation during immune response | 0.00585830455523893 |
GO:0002293 | alpha-beta T cell differentiation during immune response | 0.00585830455523893 |
GO:0002286 | T cell activation during immune response | 0.00585830455523893 |
GO:0002263 | cell activation during immune response | 0.00585830455523893 |
GO:0043367 | CD4-positive, alpha beta T cell differentiation | 0.00585830455523893 |
GO:0045086 | positive regulation of interleukin-2 biosynthetic process | 0.00585830455523893 |
GO:0030433 | ER-associated protein catabolic process | 0.00585830455523893 |
GO:0006515 | misfolded or incompletely synthesized protein catabolic process | 0.00585830455523893 |
GO:0042088 | T-helper 1 type immune response | 0.00610029345454885 |
GO:0030134 | ER to Golgi transport vesicle | 0.00662708906093496 |
GO:0045076 | regulation of interleukin-2 biosynthetic process | 0.00662708906093496 |
GO:0015026 | coreceptor activity | 0.00662708906093496 |
GO:0042094 | interleukin-2 biosynthetic process | 0.00662708906093496 |
GO:0046632 | alpha-beta T cell differentiation | 0.00662708906093496 |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 0.00678970780813472 |
GO:0046631 | alpha-beta T cell activation | 0.00732660892338999 |
GO:0032623 | interleukin-2 production | 0.00782767272809414 |
GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process | 0.00803710586941609 |
GO:0042327 | positive regulation of phosphorylation | 0.00803710586941609 |
GO:0045937 | positive regulation of phosphate metabolic process | 0.00838605134778403 |
GO:0001934 | positive regulation of protein amino acid phosphorylation | 0.00838605134778403 |
GO:0033240 | positive regulation of amine metabolic process | 0.00838605134778403 |
GO:0045764 | positive regulation of amino acid metabolic process | 0.00838605134778403 |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 0.00846147677070778 |
GO:0042108 | positive regulation of cytokine biosynthetic process | 0.0114266798003558 |
GO:0030217 | T cell differentiation | 0.0114266798003558 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0114266798003558 |
GO:0005793 | ER-Golgi intermediate compartment | 0.0114266798003558 |
GO:0018212 | peptidyl-tyrosine modification | 0.0114266798003558 |
GO:0001932 | regulation of protein amino acid phosphorylation | 0.0114266798003558 |
GO:0033238 | regulation of amine metabolic process | 0.0114266798003558 |
GO:0006521 | regulation of amino acid metabolic process | 0.0114266798003558 |
GO:0005769 | early endosome | 0.0119067654502945 |
GO:0005770 | late endosome | 0.0121287229252704 |
GO:0045727 | positive regulation of translation | 0.0123414047328301 |
GO:0042035 | regulation of cytokine biosynthetic process | 0.0132576707148612 |
GO:0031328 | positive regulation of cellular biosynthetic process | 0.0132576707148612 |
GO:0030133 | transport vesicle | 0.0132576707148612 |
GO:0042325 | regulation of phosphorylation | 0.0132576707148612 |
GO:0030098 | lymphocyte differentiation | 0.0132576707148612 |
GO:0042089 | cytokine biosynthetic process | 0.0132576707148612 |
GO:0042107 | cytokine metabolic process | 0.0132576707148612 |
GO:0051174 | regulation of phosphorus metabolic process | 0.0132576707148612 |
GO:0019220 | regulation of phosphate metabolic process | 0.0132576707148612 |
GO:0005798 | Golgi-associated vesicle | 0.0132576707148612 |
GO:0009891 | positive regulation of biosynthetic process | 0.0132576707148612 |
GO:0000502 | proteasome complex (sensu Eukaryota) | 0.0136963456940561 |
GO:0002250 | adaptive immune response | 0.0136963456940561 |
GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.0136963456940561 |
GO:0051247 | positive regulation of protein metabolic process | 0.0150731348966164 |
GO:0002521 | leukocyte differentiation | 0.0157092605783575 |
GO:0042110 | T cell activation | 0.0168404898544839 |
GO:0001816 | cytokine production | 0.019119673830591 |
GO:0018193 | peptidyl-amino acid modification | 0.0201653291102759 |
GO:0005813 | centrosome | 0.0211799199203176 |
GO:0045595 | regulation of cell differentiation | 0.0231093223870945 |
GO:0030135 | coated vesicle | 0.0231093223870945 |
GO:0005815 | microtubule organizing center | 0.0231093223870945 |
GO:0009967 | positive regulation of signal transduction | 0.023696587742515 |
GO:0046649 | lymphocyte activation | 0.023696587742515 |
GO:0030097 | hemopoiesis | 0.0242791059133819 |
GO:0048534 | hemopoietic or lymphoid organ development | 0.025736321880546 |
GO:0045321 | leukocyte activation | 0.0263156658080161 |
GO:0002520 | immune system development | 0.0263156658080161 |
GO:0006417 | regulation of translation | 0.0263156658080161 |
GO:0005768 | endosome | 0.0272498221085682 |
GO:0031326 | regulation of cellular biosynthetic process | 0.0277432975632526 |
GO:0001775 | cell activation | 0.0287734637137277 |
GO:0009889 | regulation of biosynthetic process | 0.0295070275349378 |
GO:0050793 | regulation of developmental process | 0.0316950642195714 |
GO:0045941 | positive regulation of transcription | 0.0361358867797147 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 0.0361358867797147 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0361358867797147 |
GO:0019941 | modification-dependent protein catabolic process | 0.0361358867797147 |
GO:0043632 | modification-dependent macromolecule catabolic process | 0.0361358867797147 |
GO:0051603 | proteolysis involved in cellular protein catabolic process | 0.0361358867797147 |
GO:0044257 | cellular protein catabolic process | 0.0361358867797147 |
GO:0016563 | transcription activator activity | 0.0378099684071082 |
GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0419746224953009 |
GO:0031988 | membrane-bound vesicle | 0.0421184849722903 |
GO:0030163 | protein catabolic process | 0.0421414493810656 |
GO:0031325 | positive regulation of cellular metabolic process | 0.0427463215061124 |
GO:0009893 | positive regulation of metabolic process | 0.045296838372318 |
GO:0044431 | Golgi apparatus part | 0.0477196729912479 |
GO:0051246 | regulation of protein metabolic process | 0.0477196729912479 |
GO:0031410 | cytoplasmic vesicle | 0.0477196729912479 |
GO:0031982 | vesicle | 0.0480156090498826 |
GO:0043285 | biopolymer catabolic process | 0.0499449550303376 |
Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji
links to source dataset
cell_data
uberon_data
Ontology term | p-value | n |
---|---|---|
granulocyte monocyte progenitor cell | 6.58e-18 | 67 |
macrophage dendritic cell progenitor | 6.01e-17 | 61 |
myeloid lineage restricted progenitor cell | 3.69e-16 | 66 |
classical monocyte | 6.28e-16 | 42 |
CD14-positive, CD16-negative classical monocyte | 6.28e-16 | 42 |
defensive cell | 6.86e-16 | 48 |
phagocyte | 6.86e-16 | 48 |
monopoietic cell | 8.58e-16 | 59 |
monocyte | 8.58e-16 | 59 |
monoblast | 8.58e-16 | 59 |
promonocyte | 8.58e-16 | 59 |
myeloid leukocyte | 2.15e-15 | 72 |
myeloid cell | 3.12e-15 | 108 |
common myeloid progenitor | 3.12e-15 | 108 |
leukocyte | 3.57e-12 | 136 |
hematopoietic oligopotent progenitor cell | 2.08e-11 | 161 |
hematopoietic multipotent progenitor cell | 2.08e-11 | 161 |
hematopoietic stem cell | 2.98e-11 | 168 |
angioblastic mesenchymal cell | 2.98e-11 | 168 |
hematopoietic lineage restricted progenitor cell | 8.78e-11 | 120 |
hematopoietic cell | 1.07e-10 | 177 |
nongranular leukocyte | 2.12e-10 | 115 |
Ontology term | p-value | n |
---|---|---|
immune system | 3.73e-15 | 93 |
bone marrow | 1.23e-14 | 76 |
bone element | 2.31e-14 | 82 |
hemolymphoid system | 1.27e-13 | 108 |
skeletal element | 3.61e-13 | 90 |
hematopoietic system | 5.31e-13 | 98 |
blood island | 5.31e-13 | 98 |
skeletal system | 1.26e-10 | 100 |
Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon
link to source data
Novel motifs
data
Jaspar motifs
data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 1.0927 |
MA0004.1 | 0.826076 |
MA0006.1 | 0.639288 |
MA0007.1 | 0.804807 |
MA0009.1 | 1.3275 |
MA0014.1 | 1.24048 |
MA0017.1 | 0.686276 |
MA0019.1 | 0.990656 |
MA0024.1 | 1.21731 |
MA0025.1 | 1.46617 |
MA0027.1 | 2.95767 |
MA0028.1 | 0.658629 |
MA0029.1 | 1.23771 |
MA0030.1 | 1.22561 |
MA0031.1 | 1.15713 |
MA0038.1 | 0.94098 |
MA0040.1 | 1.24388 |
MA0041.1 | 0.847069 |
MA0042.1 | 0.810843 |
MA0043.1 | 1.32783 |
MA0046.1 | 1.31611 |
MA0048.1 | 0.341392 |
MA0050.1 | 0.81185 |
MA0051.1 | 0.936307 |
MA0052.1 | 1.24796 |
MA0055.1 | 0.190716 |
MA0056.1 | 0 |
MA0057.1 | 0.333427 |
MA0058.1 | 0.716037 |
MA0059.1 | 0.714521 |
MA0060.1 | 0.492218 |
MA0061.1 | 1.15625 |
MA0063.1 | 0 |
MA0066.1 | 0.941452 |
MA0067.1 | 1.65513 |
MA0068.1 | 0.405474 |
MA0069.1 | 1.31207 |
MA0070.1 | 1.30033 |
MA0071.1 | 0.897953 |
MA0072.1 | 1.29561 |
MA0073.1 | 0.0185922 |
MA0074.1 | 2.15449 |
MA0076.1 | 0.734647 |
MA0077.1 | 1.28751 |
MA0078.1 | 1.04495 |
MA0081.1 | 0.714712 |
MA0083.1 | 1.33535 |
MA0084.1 | 1.84562 |
MA0087.1 | 1.29304 |
MA0088.1 | 0.257905 |
MA0089.1 | 0 |
MA0090.1 | 0.751469 |
MA0091.1 | 0.829044 |
MA0092.1 | 0.785956 |
MA0093.1 | 0.642957 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.956299 |
MA0101.1 | 1.55947 |
MA0103.1 | 0.628063 |
MA0105.1 | 1.5295 |
MA0106.1 | 0.986396 |
MA0107.1 | 0.556367 |
MA0108.2 | 1.15387 |
MA0109.1 | 0 |
MA0111.1 | 0.767139 |
MA0113.1 | 1.00436 |
MA0114.1 | 0.549955 |
MA0115.1 | 1.57693 |
MA0116.1 | 0.560723 |
MA0117.1 | 1.36676 |
MA0119.1 | 0.695578 |
MA0122.1 | 1.39371 |
MA0124.1 | 1.53432 |
MA0125.1 | 1.44766 |
MA0130.1 | 0 |
MA0131.1 | 1.06461 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.35921 |
MA0136.1 | 0.948776 |
MA0139.1 | 0.440097 |
MA0140.1 | 0.894983 |
MA0141.1 | 0.712476 |
MA0142.1 | 1.12317 |
MA0143.1 | 1.00455 |
MA0144.1 | 0.531867 |
MA0145.1 | 0.273764 |
MA0146.1 | 1.16674 |
MA0147.1 | 0.565108 |
MA0148.1 | 0.854239 |
MA0149.1 | 0.884158 |
MA0062.2 | 0.449458 |
MA0035.2 | 0.894194 |
MA0039.2 | 0.757898 |
MA0138.2 | 1.04628 |
MA0002.2 | 0.476938 |
MA0137.2 | 0.666381 |
MA0104.2 | 0.491226 |
MA0047.2 | 0.973066 |
MA0112.2 | 0.264678 |
MA0065.2 | 0.277623 |
MA0150.1 | 0.744617 |
MA0151.1 | 0 |
MA0152.1 | 0.902317 |
MA0153.1 | 1.43021 |
MA0154.1 | 0.838867 |
MA0155.1 | 0.711948 |
MA0156.1 | 0.669101 |
MA0157.1 | 1.09377 |
MA0158.1 | 0 |
MA0159.1 | 0.565904 |
MA0160.1 | 0.871361 |
MA0161.1 | 0 |
MA0162.1 | 0.149099 |
MA0163.1 | 1.84145 |
MA0164.1 | 1.01792 |
MA0080.2 | 0.643061 |
MA0018.2 | 0.987913 |
MA0099.2 | 0.902716 |
MA0079.2 | 0.311277 |
MA0102.2 | 1.88331 |
MA0258.1 | 0.519674 |
MA0259.1 | 0.575594 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner
link to source dataset
data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
BATF#10538 | 2 | 16.2385345282024 | 0.00491746240780997 | 0.0230024121650587 |
CTCF#10664 | 3 | 5.36025637307503 | 0.006492509252767 | 0.0280356889874197 |
FOSL1#8061 | 2 | 26.4757198109153 | 0.00186983370259098 | 0.0110273624747247 |
FOSL2#2355 | 2 | 11.2868004030411 | 0.010053458697312 | 0.0376861265887285 |
SMARCB1#6598 | 2 | 12.1684771874383 | 0.00867500222192174 | 0.0330021694188353 |
YY1#7528 | 3 | 4.91117074985386 | 0.00844145534180826 | 0.0330329781723973 |
Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA
link to data source
data
This analysis result is provided for C0 - C305 clusters.