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Coexpression cluster:C575

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Full id: C575_embryonic_CD14_CD34_immature_chorionic_Mast_testis



Phase1 CAGE Peaks

Hg19::chr10:106008834..106008840,+p@chr10:106008834..106008840
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Hg19::chr10:132517789..132517796,+p@chr10:132517789..132517796
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Hg19::chr10:81088710..81088726,+p@chr10:81088710..81088726
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Hg19::chr12:111842525..111842550,+p@chr12:111842525..111842550
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Hg19::chr12:90354099..90354111,-p@chr12:90354099..90354111
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Hg19::chr17:76858299..76858316,+p@chr17:76858299..76858316
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Hg19::chr19:55919546..55919557,-p5@UBE2S
Hg19::chr22:30602042..30602074,+p@chr22:30602042..30602074
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Hg19::chr5:1082038..1082051,-p4@SLC12A7
Hg19::chr5:1138370..1138374,-p@chr5:1138370..1138374
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Hg19::chr6:126240167..126240193,-p@chr6:126240167..126240193
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Hg19::chr6:160137409..160137424,+p@chr6:160137409..160137424
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Hg19::chr6:30685210..30685218,+p@chr6:30685210..30685218
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Hg19::chr8:125283938..125283961,+p2@ENST00000517482
Hg19::chr9:38170884..38170888,-p@chr9:38170884..38170888
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0015379potassium:chloride symporter activity0.0141286590560376
GO:0015377cation:chloride symporter activity0.0211904930526434
GO:0015296anion:cation symporter activity0.0458944863739359



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
classical monocyte1.81e-1945
CD14-positive, CD16-negative classical monocyte8.35e-1842
leukocyte1.29e-14140
myeloid leukocyte4.82e-1476
granulocyte monocyte progenitor cell8.62e-1471
macrophage dendritic cell progenitor3.13e-1365
myeloid lineage restricted progenitor cell3.60e-1370
monopoietic cell2.87e-1263
monocyte2.87e-1263
monoblast2.87e-1263
promonocyte2.87e-1263
hematopoietic cell8.27e-12182
animal cell1.94e-11679
eukaryotic cell1.94e-11679
hematopoietic stem cell2.99e-11172
angioblastic mesenchymal cell2.99e-11172
hematopoietic lineage restricted progenitor cell5.03e-11124
myeloid cell1.25e-10112
common myeloid progenitor1.25e-10112
nongranular leukocyte3.10e-10119
hematopoietic oligopotent progenitor cell1.35e-09165
hematopoietic multipotent progenitor cell1.35e-09165
native cell1.49e-07722
Uber Anatomy
Ontology termp-valuen
bone marrow4.59e-1280
bone element6.26e-1286
hematopoietic system7.42e-10102
blood island7.42e-10102
hemolymphoid system3.43e-09112
immune system5.01e-09115
skeletal element4.92e-08101
skeletal system4.92e-08101
Disease
Ontology termp-valuen
carcinoma3.83e-11106
cell type cancer7.45e-08143
disease of cellular proliferation9.85e-08239
cancer1.65e-07235


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235363.599182123557760.003862286837325890.0190495100355834
FOSL1#806137.94271594327460.005785445903376980.0260139572352344
FOSL2#235544.514720161216450.009808741154451470.0368680312902094
JUN#372554.170943064112110.004945731421922860.0231087707576146
JUNB#372648.16283537595230.001162842816154370.00794960665551785
NFYA#480044.913488186621470.007300144479678050.0301960390238463
SIRT6#51548330.7276807980050.0001180432296896320.00160357919687246
STAT3#677474.909083665338650.0002260185316605590.00249473149736812
TRIM28#1015556.196841681754170.0008567651390713570.00644898698086295



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.