Coexpression cluster:C203

Full id: C203_acute_NK_chronic_CD133_lymphoma_immature_Dendritic

Phase1 CAGE Peaks

Hg19::chr10:1999469..1999478,+	p@chr10:1999469..1999478 +
Hg19::chr10:23846022..23846029,+	p@chr10:23846022..23846029 +
Hg19::chr10:23846163..23846169,+	p@chr10:23846163..23846169 +
Hg19::chr10:23846249..23846267,+	p@chr10:23846249..23846267 +
Hg19::chr10:23846319..23846335,+	p@chr10:23846319..23846335 +
Hg19::chr10:23858616..23858621,+	p@chr10:23858616..23858621 +
Hg19::chr11:126310760..126310781,-	p7@KIRREL3
Hg19::chr11:68099033..68099038,-	p@chr11:68099033..68099038 -
Hg19::chr12:133240734..133240764,-	p@chr12:133240734..133240764 -
Hg19::chr12:4501908..4501927,+	p@chr12:4501908..4501927 +
Hg19::chr12:4524557..4524579,+	p@chr12:4524557..4524579 +
Hg19::chr12:4524619..4524632,+	p@chr12:4524619..4524632 +
Hg19::chr13:100927475..100927483,+	p@chr13:100927475..100927483 +
Hg19::chr13:100927491..100927498,+	p@chr13:100927491..100927498 +
Hg19::chr13:100927506..100927512,+	p@chr13:100927506..100927512 +
Hg19::chr13:49001034..49001075,-	p4@LPAR6
Hg19::chr13:49076795..49076798,-	p@chr13:49076795..49076798 -
Hg19::chr13:49076880..49076891,-	p@chr13:49076880..49076891 -
Hg19::chr13:49077016..49077033,-	p@chr13:49077016..49077033 -
Hg19::chr13:49077039..49077054,-	p@chr13:49077039..49077054 -
Hg19::chr13:49077093..49077104,-	p@chr13:49077093..49077104 -
Hg19::chr13:49077121..49077143,-	p@chr13:49077121..49077143 -
Hg19::chr14:77248056..77248105,-	p1@ENST00000556368
Hg19::chr14:93551934..93551950,-	p@chr14:93551934..93551950 -
Hg19::chr15:29745140..29745158,-	p2@FAM189A1
Hg19::chr15:49907736..49907748,+	p@chr15:49907736..49907748 +
Hg19::chr15:94987207..94987211,-	p@chr15:94987207..94987211 -
Hg19::chr15:95120128..95120140,-	p@chr15:95120128..95120140 -
Hg19::chr15:95120151..95120158,-	p@chr15:95120151..95120158 -
Hg19::chr16:4714466..4714476,+	p9@MGRN1
Hg19::chr16:87812662..87812682,-	p@chr16:87812662..87812682 -
Hg19::chr16:89168889..89168898,+	p10@ACSF3
Hg19::chr18:45498690..45498695,-	p@chr18:45498690..45498695 -
Hg19::chr18:45546950..45546957,-	p@chr18:45546950..45546957 -
Hg19::chr18:45546969..45546979,-	p@chr18:45546969..45546979 -
Hg19::chr18:66451511..66451519,-	p@chr18:66451511..66451519 -
Hg19::chr18:66451542..66451549,-	p@chr18:66451542..66451549 -
Hg19::chr18:73353417..73353422,+	p@chr18:73353417..73353422 +
Hg19::chr19:16228733..16228742,+	p@chr19:16228733..16228742 +
Hg19::chr19:1842983..1842999,-	p@chr19:1842983..1842999 -
Hg19::chr19:47226533..47226549,-	p@chr19:47226533..47226549 -
Hg19::chr1:10434688..10434703,+	p@chr1:10434688..10434703 +
Hg19::chr1:198985286..198985295,+	p2@ENST00000432488
Hg19::chr1:198985298..198985308,+	p1@ENST00000432488
Hg19::chr1:198985325..198985330,+	p3@ENST00000432488
Hg19::chr1:222273765..222273768,+	p@chr1:222273765..222273768 +
Hg19::chr1:3536212..3536225,+	p@chr1:3536212..3536225 +
Hg19::chr20:60705265..60705277,+	p@chr20:60705265..60705277 +
Hg19::chr21:16811526..16811529,-	p@chr21:16811526..16811529 -
Hg19::chr21:43542270..43542279,+	p@chr21:43542270..43542279 +
Hg19::chr21:43543479..43543483,-	p@chr21:43543479..43543483 -
Hg19::chr22:22294029..22294045,-	p@chr22:22294029..22294045 -
Hg19::chr2:129248071..129248083,-	p@chr2:129248071..129248083 -
Hg19::chr2:16618404..16618417,-	p@chr2:16618404..16618417 -
Hg19::chr2:16618675..16618679,-	p@chr2:16618675..16618679 -
Hg19::chr2:1997573..1997576,+	p@chr2:1997573..1997576 +
Hg19::chr2:54643949..54643962,+	p@chr2:54643949..54643962 +
Hg19::chr2:54649524..54649529,-	p@chr2:54649524..54649529 -
Hg19::chr2:58941579..58941613,+	p@chr2:58941579..58941613 +
Hg19::chr2:58942626..58942633,+	p@chr2:58942626..58942633 +
Hg19::chr2:58942673..58942680,+	p@chr2:58942673..58942680 +
Hg19::chr2:58942707..58942719,+	p@chr2:58942707..58942719 +
Hg19::chr3:124390180..124390188,+	p@chr3:124390180..124390188 +
Hg19::chr3:194968576..194968594,-	p3@XXYLT1
Hg19::chr4:117194661..117194666,-	p@chr4:117194661..117194666 -
Hg19::chr4:117248477..117248490,-	p@chr4:117248477..117248490 -
Hg19::chr4:2916272..2916283,+	p38@ADD1
Hg19::chr4:55685387..55685409,+	p@chr4:55685387..55685409 +
Hg19::chr5:83260127..83260138,-	p@chr5:83260127..83260138 -
Hg19::chr6:109702885..109702908,-	p5@CD164
Hg19::chr6:135536715..135536763,-	p@chr6:135536715..135536763 -
Hg19::chr6:20565177..20565196,-	p@chr6:20565177..20565196 -
Hg19::chr6:2750288..2750300,-	p@chr6:2750288..2750300 -
Hg19::chr6:33399093..33399111,+	p5@SYNGAP1
Hg19::chr6:6587290..6587314,+	p@chr6:6587290..6587314 +
Hg19::chr6:6588295..6588313,+	p4@LY86
Hg19::chr6:6588316..6588329,+	p3@LY86
Hg19::chr6:74438849..74438886,+	p@chr6:74438849..74438886 +
Hg19::chr7:100884779..100884815,-	p7@FIS1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0000266	mitochondrial fission	0.0392591767343367
GO:0031307	integral to mitochondrial outer membrane	0.0392591767343367
GO:0031306	intrinsic to mitochondrial outer membrane	0.0392591767343367
GO:0016559	peroxisome fission	0.0392591767343367
GO:0032592	integral to mitochondrial membrane	0.0392591767343367
GO:0048285	organelle fission	0.0436123201495787
GO:0007157	heterophilic cell adhesion	0.0475378821576717
GO:0000209	protein polyubiquitination	0.0475378821576717
GO:0002376	immune system process	0.0475378821576717
GO:0005779	integral to peroxisomal membrane	0.0475378821576717
GO:0031231	intrinsic to peroxisomal membrane	0.0475378821576717

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	2.27e-47	172
angioblastic mesenchymal cell	2.27e-47	172
hematopoietic cell	9.28e-46	182
hematopoietic oligopotent progenitor cell	2.74e-44	165
hematopoietic multipotent progenitor cell	2.74e-44	165
myeloid cell	7.88e-37	112
common myeloid progenitor	7.88e-37	112
leukocyte	5.82e-35	140
hematopoietic lineage restricted progenitor cell	1.34e-28	124
nongranular leukocyte	9.37e-27	119
granulocyte monocyte progenitor cell	9.06e-24	71
myeloid leukocyte	2.18e-23	76
myeloid lineage restricted progenitor cell	6.55e-21	70
macrophage dendritic cell progenitor	7.81e-21	65
monopoietic cell	1.20e-19	63
monocyte	1.20e-19	63
monoblast	1.20e-19	63
promonocyte	1.20e-19	63
CD14-positive, CD16-negative classical monocyte	2.13e-16	42
classical monocyte	6.81e-16	45
lymphocyte	1.40e-07	53
common lymphoid progenitor	1.40e-07	53
lymphoid lineage restricted progenitor cell	1.54e-07	52

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.93e-25	102
blood island	1.93e-25	102
hemolymphoid system	2.69e-25	112
bone marrow	3.37e-19	80
immune system	7.70e-19	115
bone element	1.57e-17	86
adult organism	8.11e-12	115
skeletal element	1.89e-11	101
skeletal system	1.89e-11	101

Disease

Ontology term	p-value	n
hematologic cancer	2.37e-18	51
immune system cancer	2.37e-18	51
leukemia	4.18e-16	39
myeloid leukemia	1.04e-12	31

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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