Coexpression cluster:C4136

Full id: C4136_small_Intestinal_endometrial_Mesothelial_Fibroblast_Prostate_colon

Phase1 CAGE Peaks

Hg19::chr2:162930503..162930521,-	p3@DPP4
Hg19::chr2:162930536..162930551,-	p5@DPP4
Hg19::chr2:162930560..162930613,-	p1@DPP4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	6.41e-14	180
muscle precursor cell	6.50e-14	57
myoblast	6.50e-14	57
multi-potent skeletal muscle stem cell	6.50e-14	57
muscle cell	1.11e-12	54
mesodermal cell	2.71e-11	119
contractile cell	9.46e-11	59
smooth muscle cell	1.06e-10	42
smooth muscle myoblast	1.06e-10	42
electrically responsive cell	1.48e-10	60
electrically active cell	1.48e-10	60
vascular associated smooth muscle cell	1.63e-09	32
fibroblast	3.28e-07	75
cardiocyte	4.93e-07	16

Uber Anatomy

Ontology term	p-value	n
trunk mesenchyme	1.80e-15	143
muscle tissue	8.54e-14	63
musculature	8.54e-14	63
musculature of body	8.54e-14	63
epithelial tube	1.46e-13	118
dermomyotome	2.25e-13	70
skeletal muscle tissue	2.71e-13	61
striated muscle tissue	2.71e-13	61
myotome	2.71e-13	61
unilaminar epithelium	5.05e-13	138
splanchnic layer of lateral plate mesoderm	1.26e-11	84
multilaminar epithelium	1.52e-10	82
somite	2.98e-10	83
paraxial mesoderm	2.98e-10	83
presomitic mesoderm	2.98e-10	83
presumptive segmental plate	2.98e-10	83
trunk paraxial mesoderm	2.98e-10	83
presumptive paraxial mesoderm	2.98e-10	83
trunk	5.33e-10	216
mesenchyme	3.58e-09	238
entire embryonic mesenchyme	3.58e-09	238
cardiovascular system	6.39e-08	110
circulatory system	1.63e-07	113
gut epithelium	1.94e-07	54
mesoderm	3.92e-07	448
mesoderm-derived structure	3.92e-07	448
presumptive mesoderm	3.92e-07	448
artery	6.07e-07	42
arterial blood vessel	6.07e-07	42
arterial system	6.07e-07	42

Disease

Ontology term	p-value	n
ovarian cancer	6.13e-09	14
reproductive organ cancer	8.47e-07	29

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CHD2#1106	3	10.3440228341169	0.000903370110274688	0.00661388509968301
CTCF#10664	3	5.36025637307503	0.006492509252767	0.028005582927876
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0326120773796994
EBF1#1879	3	8.906466846569	0.0014152328356098	0.00916793835245332
EP300#2033	3	6.7739417262232	0.00321688050010379	0.0167749042615508
FOXA1#3169	3	11.0814197493855	0.00073475527569867	0.00582268049462731
HDAC2#3066	3	13.4156202366263	0.000414076139985721	0.0039200233850588
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0173231862648405
TCF7L2#6934	3	10.7701765631373	0.000800318129839838	0.00614953098604641

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.