Coexpression cluster:C4330

Full id: C4330_leiomyoma_Smooth_Fibroblast_Preadipocyte_Mesenchymal_mesenchymal_Adipocyte

Phase1 CAGE Peaks

Hg19::chr3:45266600..45266635,-	p2@TMEM158
Hg19::chr3:45266648..45266677,-	p3@TMEM158
Hg19::chr3:45267139..45267195,-	p1@ENST00000325090

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
electrically responsive cell	2.65e-23	61
electrically active cell	2.65e-23	61
muscle precursor cell	2.14e-20	58
myoblast	2.14e-20	58
multi-potent skeletal muscle stem cell	2.14e-20	58
muscle cell	2.07e-19	55
smooth muscle cell	2.63e-19	43
smooth muscle myoblast	2.63e-19	43
non-terminally differentiated cell	9.54e-19	106
contractile cell	6.19e-18	59
vascular associated smooth muscle cell	4.87e-17	32
aortic smooth muscle cell	5.45e-10	10
mesodermal cell	5.39e-09	121
embryonic cell	3.90e-08	250
neuronal stem cell	1.93e-07	8

Uber Anatomy

Ontology term	p-value	n
paraxial mesoderm	6.01e-24	72
presumptive paraxial mesoderm	6.01e-24	72
somite	1.28e-23	71
presomitic mesoderm	1.28e-23	71
presumptive segmental plate	1.28e-23	71
dermomyotome	1.28e-23	71
trunk paraxial mesoderm	1.28e-23	71
dense mesenchyme tissue	2.46e-23	73
epithelial vesicle	1.06e-19	78
multilaminar epithelium	4.17e-19	83
artery	4.30e-18	42
arterial blood vessel	4.30e-18	42
arterial system	4.30e-18	42
skeletal muscle tissue	5.28e-18	62
striated muscle tissue	5.28e-18	62
myotome	5.28e-18	62
muscle tissue	6.23e-17	64
musculature	6.23e-17	64
musculature of body	6.23e-17	64
trunk mesenchyme	1.34e-14	122
systemic artery	5.59e-14	33
systemic arterial system	5.59e-14	33
epithelial tube open at both ends	9.29e-12	59
blood vessel	9.29e-12	59
blood vasculature	9.29e-12	59
vascular cord	9.29e-12	59
unilaminar epithelium	3.10e-11	148
splanchnic layer of lateral plate mesoderm	3.53e-10	83
blood vessel smooth muscle	5.45e-10	10
arterial system smooth muscle	5.45e-10	10
artery smooth muscle tissue	5.45e-10	10
aorta smooth muscle tissue	5.45e-10	10
mesenchyme	9.00e-09	160
entire embryonic mesenchyme	9.00e-09	160
smooth muscle tissue	9.04e-09	15
vessel	1.26e-08	68
trunk	2.02e-08	199
mesoderm	2.89e-08	315
mesoderm-derived structure	2.89e-08	315
presumptive mesoderm	2.89e-08	315
dermis	1.37e-07	9
dermatome	1.37e-07	9
future dermis	1.37e-07	9
vasculature	4.40e-07	78
vascular system	4.40e-07	78

Disease

Ontology term	p-value	n
ovarian cancer	3.89e-10	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0326735754734825
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0323494432600741
SMC3#9126	2	10.0299552299552	0.012665637976747	0.0457743291803405

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.