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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:49, 17 September 2013


Full id: C1672_seminal_CD14_Mast_CD34_immature_mesenchymal_pituitary



Phase1 CAGE Peaks

Hg19::chr12:52430722..52430738,-p@chr12:52430722..52430738
-
Hg19::chr12:52444895..52444916,-p@chr12:52444895..52444916
-
Hg19::chr2:157189405..157189420,+p@chr2:157189405..157189420
+
Hg19::chr2:157189464..157189474,+p@chr2:157189464..157189474
+
Hg19::chr8:29208519..29208527,+p@chr8:29208519..29208527
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte4.61e-3442
CD14-positive, CD16-negative classical monocyte4.61e-3442
defensive cell2.46e-2748
phagocyte2.46e-2748
myeloid leukocyte3.31e-2472
granulocyte monocyte progenitor cell1.54e-2367
myeloid lineage restricted progenitor cell5.95e-2266
leukocyte9.12e-22136
macrophage dendritic cell progenitor6.79e-2161
hematopoietic lineage restricted progenitor cell1.29e-20120
monopoietic cell5.72e-2059
monocyte5.72e-2059
monoblast5.72e-2059
promonocyte5.72e-2059
nongranular leukocyte3.77e-19115
hematopoietic stem cell2.27e-13168
angioblastic mesenchymal cell2.27e-13168
hematopoietic cell6.81e-13177
hematopoietic oligopotent progenitor cell1.74e-12161
hematopoietic multipotent progenitor cell1.74e-12161
myeloid cell2.37e-11108
common myeloid progenitor2.37e-11108
stuff accumulating cell1.10e-1087
intermediate monocyte2.66e-079
CD14-positive, CD16-positive monocyte2.66e-079
Uber Anatomy
Ontology termp-valuen
bone marrow3.38e-2176
hematopoietic system5.59e-2098
blood island5.59e-2098
bone element3.29e-1982
skeletal element6.57e-1990
immune system2.29e-1793
skeletal system1.04e-16100
hemolymphoid system1.10e-16108
adult organism6.09e-16114
organ7.59e-07503


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.16.94052
MA0004.10.626788
MA0006.11.14863
MA0007.10.606704
MA0009.11.11255
MA0014.12.48957
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.12.31153
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.13.85027
MA0055.10.0853006
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.860776
MA0061.11.44118
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.11.36174
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.12.53033
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.12.26263
MA0106.10.779931
MA0107.10.985964
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.11.76306
MA0117.12.59297
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.11.39016
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.868598
MA0146.10.333008
MA0147.11.00307
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.23.41529
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.858845
MA0047.20.767096
MA0112.20.839774
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.11.3196
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.12.27598
MA0163.11.99104
MA0164.10.810347
MA0080.20.456437
MA0018.23.06493
MA0099.20.699641
MA0079.27.74761
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672312.11053838593430.001127176470125940.00772702220961488
CCNT2#90556.336201576962639.78880505817628e-050.00138885071521651
CTBP2#1488225.08680013573130.002461438599678380.0138455424092105
E2F1#186954.907389214879320.0003512818099256460.00352358057499275
E2F6#187655.017155731697390.0003144978599297790.00322492312157154
ELK4#2005412.98854532677446.83810524411663e-050.00109066107756612
FOXA1#316936.648851849631270.006389025166568720.027804958720363
MEF2C#4208216.52454179704960.005579850077982050.025240556232431
PAX5#507945.335652424942260.002223389586187790.0127748575117933
SETDB1#9869216.12801047120420.00585057846659340.0262683704257147
SP1#666744.558705102512720.00407573565781680.0194777046017538
SRF#672238.278306957300690.003404846073776150.017355591736986
TCF7L2#6934510.77017656313736.89693748574565e-060.00019953164932792
USF1#739145.089199421766370.00266867775360040.0147140764390388



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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