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Coexpression cluster:C4080: Difference between revisions

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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 12:38, 17 September 2013


Full id: C4080_CD19_CD4_Dendritic_Peripheral_CD14_B_Eosinophils



Phase1 CAGE Peaks

Hg19::chr21:45663884..45663922,-p@chr21:45663884..45663922
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Hg19::chr21:45663952..45663967,-p@chr21:45663952..45663967
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Hg19::chr2:227701085..227701125,-p@chr2:227701085..227701125
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.73e-46136
lymphocyte2.72e-4253
common lymphoid progenitor2.72e-4253
nongranular leukocyte3.41e-42115
lymphoid lineage restricted progenitor cell2.37e-4152
nucleate cell3.33e-4055
hematopoietic lineage restricted progenitor cell4.14e-39120
hematopoietic stem cell2.57e-35168
angioblastic mesenchymal cell2.57e-35168
hematopoietic cell2.77e-32177
lymphocyte of B lineage3.03e-3224
pro-B cell3.03e-3224
hematopoietic oligopotent progenitor cell2.68e-30161
hematopoietic multipotent progenitor cell2.68e-30161
B cell1.53e-2214
mature alpha-beta T cell1.25e-1318
alpha-beta T cell1.25e-1318
immature T cell1.25e-1318
mature T cell1.25e-1318
immature alpha-beta T cell1.25e-1318
CD4-positive, alpha-beta T cell2.23e-106
T cell5.83e-1025
pro-T cell5.83e-1025
classical monocyte6.89e-0942
CD14-positive, CD16-negative classical monocyte6.89e-0942
myeloid leukocyte6.47e-0872
mesenchymal cell2.14e-07354
granulocyte monocyte progenitor cell2.60e-0767
macrophage dendritic cell progenitor3.67e-0761
defensive cell4.05e-0748
phagocyte4.05e-0748
connective tissue cell6.89e-07361
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.23e-13108
hematopoietic system1.68e-1398
blood island1.68e-1398
immune system3.13e-1093
hemopoietic organ4.51e-097
immune organ4.51e-097


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.12.15619
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.12.1667
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.11.52002
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0107199
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538324.35780179230366.91705216281876e-050.00109989343914834
BCL11A#53335328.36945510360714.37778126761649e-050.000778231655844423
BCL3#602223.03140186915890.002464674760842910.013855537051764
BCLAF1#9774321.65264761012189.8473954032885e-050.00139337776524055
BHLHE40#8553229.91454236465160.001467483527106140.00939857190699937
EBF1#187938.9064668465690.00141523283560980.00916395945925056
ELF1#199734.258097958807540.01295179875054610.0463148979561831
FOSL2#2355211.28680040304110.0100534586973120.0376807167733201
FOXA2#3170216.42030916844350.004810682352105480.0225950195256136
GATA3#2625218.15767757147070.003944546819279620.0189539694160913
HNF4G#3174219.16894835096450.003543986611284220.0179744763838341
IRF4#3662321.91451268674419.49854535978121e-050.00136849024531686
MAX#414936.452555509007120.003721913834265510.0186872246015507
MEF2A#4205212.4954872730960.008235029478029740.0324893564391035
MEF2C#4208227.54090299508270.001729119938369690.0106484791109967
MYC#460935.22228187160940.007020843755740150.0294999155538198
NFKB1#479035.488063424193840.006049381815655430.0269984781609862
PAX5#507936.669565531177830.003370290999677260.0173163684614205
PBX3#5090214.60967512449610.006056122473217890.0268427354318382
POU2F2#545239.106124057742520.001324165192682130.0088327577798128
SMARCB1#6598212.16847718743830.008675002221921740.032996159846139
SMARCC1#6599229.10890621308760.001549200814224140.00984346193567893
SMC3#9126210.02995522995520.0126656379767470.0457600776508624
SP1#666735.69838137814090.005403962701712170.0246952157435949
TRIM28#10155212.39368336350830.008368344129438470.0329195635441796
USF1#739136.361499277207960.00388404057290560.0190631755906616
WRNIP1#56897273.21330956625070.000247093641135960.00268562938771969
YY1#752834.911170749853860.008441455341808260.0329921845087611
ZBTB33#10009221.10981668665410.002928597060603240.0156394001335758
ZEB1#6935211.25895467836260.01010222676646330.0378187132146627



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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