Coexpression cluster:C12: Difference between revisions
From FANTOM5_SSTAR
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
|ontology_enrichment_uberon=UBERON:0007023!6.30e-26!115;UBERON:0002390!8.79e-25!102;UBERON:0003061!8.79e-25!102;UBERON:0002193!7.26e-22!112;UBERON:0002371!2.40e-18!80;UBERON:0001474!6.14e-16!86;UBERON:0002405!1.17e-13!115;UBERON:0004765!2.45e-10!101;UBERON:0001434!2.45e-10!101;UBERON:0000178!9.54e-07!15;UBERON:0000179!9.54e-07!15;UBERON:0000463!9.54e-07!15 | |ontology_enrichment_uberon=UBERON:0007023!6.30e-26!115;UBERON:0002390!8.79e-25!102;UBERON:0003061!8.79e-25!102;UBERON:0002193!7.26e-22!112;UBERON:0002371!2.40e-18!80;UBERON:0001474!6.14e-16!86;UBERON:0002405!1.17e-13!115;UBERON:0004765!2.45e-10!101;UBERON:0001434!2.45e-10!101;UBERON:0000178!9.54e-07!15;UBERON:0000179!9.54e-07!15;UBERON:0000463!9.54e-07!15 | ||
|pathway_enrichment=0.000674873521766305;0.0328611491752362;6;268;MAPK signaling pathway (KEGG):04010!1.17180970066546e-05;0.00502391603525407;6;128;Osteoclast differentiation (KEGG):04380!0.00076355917120262;0.0345237825265185;4;104;Chagas disease (American trypanosomiasis) (KEGG):05142!7.42685397927728e-05;0.013381692011009;3;21;Nicotine Activity on Dopaminergic Neurons (Wikipathways):WP1602!1.58733524020666e-05;0.00502391603525407;6;135;Adipogenesis (Wikipathways):WP236!0.000294400094082089;0.0250014498491475;3;33;Serotonin HTR1 Group and FOS Pathway (Wikipathways):WP722!0.000282274063921562;0.0250014498491475;4;80;Opioid Signalling (Reactome):REACT_15295!0.00109856861414876;0.0419420489568516;5;197;Synaptic Transmission (Reactome):REACT_13685!0.00045524406662886;0.0288169494176069;5;162;TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9!0.000220217376952482;0.0250014498491475;4;75;Kit Receptor up reg. targets (Netpath):NetPath_6!8.45604550458703e-05;0.013381692011009;6;182;B Cell Receptor down reg. targets (Netpath):NetPath_12!0.000315974089720663;0.0250014498491475;8;433;IL-2 up reg. targets (Netpath):NetPath_14!0.000522575191418878;0.0300718269243773;3;40;IL-3 up reg. targets (Netpath):NetPath_15!0.0006725892375556;0.0328611491752362;2;10;IL-3 down reg. targets (Netpath):NetPath_15!0.00112640573817769;0.0419420489568516;7;406;{GRB2,414} (Static Module):NA!0.000372225637572235;0.0261798698425806;4;86;{JUN,88} (Static Module):NA!0.00106750693941109;0.0419420489568516;3;51;{RXRA,51} (Static Module):NA | |pathway_enrichment=0.000674873521766305;0.0328611491752362;6;268;MAPK signaling pathway (KEGG):04010!1.17180970066546e-05;0.00502391603525407;6;128;Osteoclast differentiation (KEGG):04380!0.00076355917120262;0.0345237825265185;4;104;Chagas disease (American trypanosomiasis) (KEGG):05142!7.42685397927728e-05;0.013381692011009;3;21;Nicotine Activity on Dopaminergic Neurons (Wikipathways):WP1602!1.58733524020666e-05;0.00502391603525407;6;135;Adipogenesis (Wikipathways):WP236!0.000294400094082089;0.0250014498491475;3;33;Serotonin HTR1 Group and FOS Pathway (Wikipathways):WP722!0.000282274063921562;0.0250014498491475;4;80;Opioid Signalling (Reactome):REACT_15295!0.00109856861414876;0.0419420489568516;5;197;Synaptic Transmission (Reactome):REACT_13685!0.00045524406662886;0.0288169494176069;5;162;TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9!0.000220217376952482;0.0250014498491475;4;75;Kit Receptor up reg. targets (Netpath):NetPath_6!8.45604550458703e-05;0.013381692011009;6;182;B Cell Receptor down reg. targets (Netpath):NetPath_12!0.000315974089720663;0.0250014498491475;8;433;IL-2 up reg. targets (Netpath):NetPath_14!0.000522575191418878;0.0300718269243773;3;40;IL-3 up reg. targets (Netpath):NetPath_15!0.0006725892375556;0.0328611491752362;2;10;IL-3 down reg. targets (Netpath):NetPath_15!0.00112640573817769;0.0419420489568516;7;406;{GRB2,414} (Static Module):NA!0.000372225637572235;0.0261798698425806;4;86;{JUN,88} (Static Module):NA!0.00106750693941109;0.0419420489568516;3;51;{RXRA,51} (Static Module):NA | ||
|tfbs_overrepresentation=1,0.853244,1,0.993562,0.999805,0.887454,0.991773,0.99968,0.999942,0.996374,0.999781,0.998883,0.999672,0.999965,0.999992,0.860136,0.999995,0.997031,0.901301,0.999792,0.999958,0.843175,0.998423,0.999915,0.95148,0.999997,0.974527,0.999985,0.999998,0.788962,0.981487,0.999543,0.80364,0.999998,0.888267,0.95312,1,0.660596,0.882457,0.999606,0.956686,0.953008,0.97785,1,0.820061,0.87602,0.995759,0.994284,0.998538,0.996316,0.98589,0.971515,0.998993,0.999703,0.999858,0.914053,0.986669,1,0.980556,0.820708,0.998879,0.999948,0.501397,0.999902,0.953481,0.983808,0.996996,0.688441,0.887348,0.998683,0.999983,0.985973,0.999666,0.998221,0.766619,0.987825,0.998803,0.770847,0.940812,0.751868,0.829403,0.996238,0.879175,0.983991,0.999994,1,0.798201,1,1,0.980742,0.883195,0.999833,0.991461,0.909129,0.990174,0.999293,1,0.999999,0.999337,0.999938,0.998481,1,0.999982,0.985993,0.999999,0.945281,0.999955,1,0.99999,0.993678,0.999999,0.995816,0.991367,0.960795,0.683221,0.399475,0.99581,0.982109,0.999992,0.99894,0.999967,0.999857,0.626245,0.99998,0.992743,0.999987,0.99996,0.974197,0.980458,0.999991,0.943881,0.999221,0.999785,0.750069,0.999925,0.999199,0.998501,0.977016,0.984949,0.770449,0.991115,0.998815,1,0.99259,0.999999,0.981505,0.979462,0.987977,0.798084,0.999989,1,0.999829,0.999886,0.999503,0.929419,0.998573,0.58804,0.998974,0.925642,0.969874,0.973331,0.999988,0.99997,0.999998,0.999894,0.946966,0.983693,0.998762,0.834077,1,0.964096,0.978908,0.995765,0.99999,0.999906,0.952234,0.999994,0.971829,0.867841,0.863242,0.989453,0.876967,0.581276,0.998838,0.99174,0.999918,1,0.937162,0.984849,0.999999,1,0.973548,0.983167,1,0.935629,0.904766,0.999998,0.949842,0.9859,0.952277,0.999992,0.999729,0.974388,0.984276,0.999306,0.999958,0.999971,1,1,0.99999,0.999869,0.934342,0.999899,0.994463,1,0.99999,0.998661,0.998239,0.999017,0.99783,0.996662,0.999998,0.959643,0.997742,0.960295,0.998579,0.999996,0.999335,0.995939,0.99916,1,1,0.989199,0.998821,0.301629,0.999716,0.999667,0.999987,0.996394,0.999982,0.999954,1,0.966766,0.962385,0.99993,1,0.969377,0.999612,1,0.701718,0.999997,0.999952,1,0.999907,0.543207,0.999588,0.999881,0.546121,0.994859,1,0.937715,0.999146,1,0.99999,0.947151,0.925596,0.999975,0.994814,0.999803,0.996979,0.999998,0.995347,0.997106,1,0.995546,0.974729,0.999885,0.9999,1,0.998365,1,1,0.999999,1,0.996577,1,1,0.999961,0.99999,0.996821,1,0.995143,1,0.990858,1,0.999617,1,0.999995,0.958631,0.999997,1,1,1,0.99932,0.999995,0.993034,0.999864,0.999988,0.995489,0.999961,1,0.637969,1,0.997878,0.948326,1,0.999642,1,0.999999,0.999801,1,0.999938,0.999931,0.999926,0.993662,1,0.998359,0.999932,1,0.996631,0.999999,0.999996,0.795666,0.999412,0.999999,0.971734,0.99994,0.999847,1,1,1,1,0.999998,0.999995,0.992916,0.999996,0.999851,1,1,1,0.975252,1,0.998098,0.99743,1,1,0.999639,0.999103,0.999974,0.999749,1,1,1,1,0.999689,0.96376,1,0.977161,0.997863,0.999935,1,0.995018,0.996464,0.999998,1,0.999912,0.999999,0.996985,0.990762,0.997989,0.999991,1,1,0.977224,1,0.999756,0.861802,0.999276,0.999715,1,1,0.999985,0.996582,0.999502,0.752961,1,0.999999,0.996699,0.969746,0.996614,0.999479,0.999999,0.999989,0.965017,0.999999,0.964982,1,0.999989,0.999996,0.999986,0.823153,0.998609,0.999747,0.999919,1,0.999987,0.972758,0.999995,1,0.937548,1,0.999378,0.999999,0.999878,0.977661,0.998165,1,1,0.998576,1,1,0.998798,1,0.960182,1,1,1,0.213791,1,0.964068,0.964031,0.999961,0.965704,0.998869,0.756163,0.814786,1,0.999998,0.999752,0.999986,0.99996,1,0.983648,0.572001,0.999995,0.968268,0.990522,0.988811,0.944256,0.987919,0.992438,0.964898,1,0.999602,1,1,0.999993,0.949318,1,0.486458,1,0.993551,0.969373,0.999989,1,0.966765,0.99901,0.234079,0.99986,0.301415,1,0.320522,0.0343982,0.993185,0.968946,0.328046,0.99882,0.974207,1,0.968829,0.764847,0.99919,0.998465,1,0.999999,0.999264,0.99133,3.81272e-16,0.576009,0.999998,0.988455,0.994551,0.99934,0.999982,0.999855,1,0.974308,1,1,0.999346,1,0.999906,0.871397,0.526901,0.998457,0.132916,0.999855,0.999876,1,0.00250471,0.914191,0.996195,0.99864,0.996191,1,0.999956,0.99974,0.97297,0.743938,0.999903,0.999763,0.999995,0.999972,0.955826,0.978964,0.999498,0.999997,0.999412,0.793888,0.999493,0.957544,0.996692,0.999911,0.617419,0.998008,0.849667,0.986884,0.741106,0.906344,0.917032,0.998993,0.796212,0.965867,1,0.999998,0.829476,0.999994,1,0.797701,1,0.982094,0.81215,0.999968,0.999799,0.999924,0.999826,0.954336,0.743518,0.999754,1,0.982682,0.998937,0.521598,0.997263,0.997653,0.999882,0.999763,0.974439,0.934406,0.999987,0.0833681,1,0.999997,0.99999,0.999855,0.966236,1,0.976944,0.828133,0.995405,0.999446,0.984911,1,0.997412,0.857113,0.994541,1,0.219764,0.999933,0.999966,1,0.953516,1,0.999998,0.999089,0.938613,0.941005,0.993665,0.999999,0.999999,0.997656,0.995843,0.999845,0.979987,1,1,0.998769,0.999753,0.585304,0.000321488,1,1,0.992444,0.798813,0.999597,0.999342,0.635542,0.101924,0.963045,0.992174,0.991697,0.957484,0.999704,0.995331,1,1,0.999994,0.895387,0.2673,0.995935,0.974347,0.77294,0.999306,1,0.994216,0.99997,0.95546,0.973265,1,1,0.902639,0.843757,0.727002,0.19094,0.99989,0.870069,0.990143,0.970583,0.981526,0.998359,1,0.999403,0.999826,0.991515,0.94433,1,0.999589,1,0.999991,1,0.998948,0.999954,0.999793,0.947253,1,0.999175,0.999896,0.945239,0.533539,0.999919,0.99996,1,0.940076,0.997103,0.999865,0.999903,0.600788,1,0.994591,0.996777,0.949123,0.988317,0.994686,0.997989,0.999965,0.999994,0.998333,1,1,1,0.999974,1,0.999876,0.99678,0.996202,0.999999,0.9999,1,0.985533,0.918589,0.980623,0.99995,0.999994,0.999923,0.910615,1,1,0.999705,0.984171,0.999878,0.999999,1,0.872825,0.999995,0.999953,0.992607,0.933826,1,0.999381,0.999956,0.137798,1,0.999693,0.999703,1,1,1,0.996377,0.72583,1,0.986066,0.999758,0.855543,0.843908,0.991105,1,0.998239,0.575116,0.999954,0.336729,0.963286,1,1,1,0.999428,1,1,1,0.999962,1,1,0.996413,0.934554,0.946179,0.919509,0.994987,0.995865,0.994863,0.998817,0.100253,1,1,1,0.999833,1,1,0.224522,1,1,1,1,0.998243,1,0.558288,1,1,1,0.137722,0.959894,0.577191,0.303915,0.904384,0.768517,0.170744,0.85208,0.324681,0.746222,0.998926,0.837872,1,0.0833052,0.440289,0.043752,0.999754,0.99791,0.0813769,0.710394,0.171134,0.964629,1,0.988679,0.99862,0.71321,0.989314,0.9205,1,0.999999,0.997908,0.94396,1,1,0.0320567,0.99995,0.995948,1,1,0.996393,0.99823,1,0.999869,1,0.843742,0.999999,0.986114,0.999383,0.999999,0.99916,1,1,0.999204,0.999413,0.999993,0.957122,0.999977,0.894276,0.432544,0.962436,0.290135,0.975251,0.903892,0.76105,1,0.999593,0.032239,0.918583,0.995054,0.969985,0.917251,1,0.00156663,0.902611,0.801102,0.999936,1,0.18256,0.998321,0.989327,0.866133,0.881728,0.997695,1,1,0.999997,0.974763,1,1,1,0.999835,1,0.994669,1,0.997718,0.99999,0.999989,0.897194,1,0.797354,1,0.99216,0.99981,1,0.996561,0.999577,0.993114,0.999709,0.998356,0.938042,0.99983,1,0.99978,1,1,0.990928,0.999922,0.976205,0.997272,0.999976,0.992581,0.866175,0.889462,0.99925,0.999946,0.999701,1,0.431469,0.999915,0.983288,0.999995,0.956,0.99992,1,0.98375,1,0.459997,0.989485,0.66927,0.99819,0.992789,0.978755,1,0.871934,0.998226,0.974082,0.999387,0.999826,0.995893,0.999908,0.998078,0.993639,0.83862,0.969493,0.993181,1,0.735172,0.940241,0.999928,0.953467,0.834151,0.0747486,0.957611,0.90034,0.999774,0.999021,0.994182,0.992968,0.369269,0.999997,0.911828,0.999975,0.886115,0.983638,0.99998,0.746681,0.999937,0.999897,0.999471,0.993785,0.999961,0.969636,0.998152,0.862932,0.979052,0.999998,0.924191,0.997627,0.999998,0.971995,0.221828,0.99638,0.4033,0.896172,0.988967,0.779332,0.999143,0.999812,0.908497,0.998949,0.992756,0.666617,0.992287,0.475793,0.964835,0.999999,0.993417,0.989745,0.875587,0.993468,1,0.999992,0.996707,0.999997,0.994446,0.999985,0.999989,0.991571,0.946856,0.998858,0.923584,0.994232,0.999998,0.323882,0.354275,0.991662,0.999019,0.0598631,0.996237,0.927716,0.999999,0.999257,0.944061,0.844776,0.999147,0.997595,0.999765,0.999921,0.996234,0.999193,0.928824,0.99998,0.999487,0.999996,0.99978,0.974064,0.937531,0.996428,0.916589,0.995615,0.998756,0.958215,1,0.361526,0.126961,0.998626,0.999939,0.915496,0.989518,0.943774,0.926982,0.999954,0.997332,0.999725,0.998001,0.999683,0.997675,0.96835,0.967025,0.994816,0.999974,0.98075,0.915628,0.999268,0.99995,0.999099,0.997858,0.999994,0.998948,0.996499,0.999996,0.845474,0.999998,1,0.999839,0.976426,1,0.999923,0.999981,0.999945,0.998828,0.999991,0.999956,0.999685,0.99958,0.999985 | |||
}} | }} | ||
Revision as of 17:08, 8 August 2012
Full id: C12_Mast_Basophils_immature_chorionic_mature_CD14_Eosinophils
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 0.000674873521766305 | 0.0328611491752362 | 6 | 268 | MAPK signaling pathway (KEGG):04010 |
| 1.17180970066546e-05 | 0.00502391603525407 | 6 | 128 | Osteoclast differentiation (KEGG):04380 |
| 0.00076355917120262 | 0.0345237825265185 | 4 | 104 | Chagas disease (American trypanosomiasis) (KEGG):05142 |
| 7.42685397927728e-05 | 0.013381692011009 | 3 | 21 | Nicotine Activity on Dopaminergic Neurons (Wikipathways):WP1602 |
| 1.58733524020666e-05 | 0.00502391603525407 | 6 | 135 | Adipogenesis (Wikipathways):WP236 |
| 0.000294400094082089 | 0.0250014498491475 | 3 | 33 | Serotonin HTR1 Group and FOS Pathway (Wikipathways):WP722 |
| 0.000282274063921562 | 0.0250014498491475 | 4 | 80 | Opioid Signalling (Reactome):REACT_15295 |
| 0.00109856861414876 | 0.0419420489568516 | 5 | 197 | Synaptic Transmission (Reactome):REACT_13685 |
| 0.00045524406662886 | 0.0288169494176069 | 5 | 162 | TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9 |
| 0.000220217376952482 | 0.0250014498491475 | 4 | 75 | Kit Receptor up reg. targets (Netpath):NetPath_6 |
| 8.45604550458703e-05 | 0.013381692011009 | 6 | 182 | B Cell Receptor down reg. targets (Netpath):NetPath_12 |
| 0.000315974089720663 | 0.0250014498491475 | 8 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
| 0.000522575191418878 | 0.0300718269243773 | 3 | 40 | IL-3 up reg. targets (Netpath):NetPath_15 |
| 0.0006725892375556 | 0.0328611491752362 | 2 | 10 | IL-3 down reg. targets (Netpath):NetPath_15 |
| 0.00112640573817769 | 0.0419420489568516 | 7 | 406 | {GRB2,414} (Static Module):NA |
| 0.000372225637572235 | 0.0261798698425806 | 4 | 86 | {JUN,88} (Static Module):NA |
| 0.00106750693941109 | 0.0419420489568516 | 3 | 51 | {RXRA,51} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030019 | tryptase activity | 7.43611367369899e-05 |
| GO:0004295 | trypsin activity | 0.000323373398854325 |
| GO:0005515 | protein binding | 0.00138938624136048 |
| GO:0006469 | negative regulation of protein kinase activity | 0.002887730609746 |
| GO:0033673 | negative regulation of kinase activity | 0.002887730609746 |
| GO:0032502 | developmental process | 0.002887730609746 |
| GO:0051348 | negative regulation of transferase activity | 0.002887730609746 |
| GO:0007275 | multicellular organismal development | 0.00321797878216874 |
| GO:0044464 | cell part | 0.00321797878216874 |
| GO:0007165 | signal transduction | 0.00354595518452706 |
| GO:0007154 | cell communication | 0.00610559733144884 |
| GO:0030097 | hemopoiesis | 0.00610559733144884 |
| GO:0048869 | cellular developmental process | 0.00610559733144884 |
| GO:0030154 | cell differentiation | 0.00610559733144884 |
| GO:0043086 | negative regulation of catalytic activity | 0.00621226600627567 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.00698126053173538 |
| GO:0043565 | sequence-specific DNA binding | 0.00765930947354699 |
| GO:0002520 | immune system development | 0.00765930947354699 |
| GO:0016020 | membrane | 0.00765930947354699 |
| GO:0008283 | cell proliferation | 0.0102666293675061 |
| GO:0003700 | transcription factor activity | 0.0106647296757731 |
| GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 0.0111136459218742 |
| GO:0050789 | regulation of biological process | 0.0113441880629517 |
| GO:0004252 | serine-type endopeptidase activity | 0.0125388208720837 |
| GO:0005886 | plasma membrane | 0.0125388208720837 |
| GO:0006366 | transcription from RNA polymerase II promoter | 0.0142514343960738 |
| GO:0050794 | regulation of cellular process | 0.0148406718969135 |
| GO:0030201 | heparan sulfate proteoglycan metabolic process | 0.0153030598693199 |
| GO:0048856 | anatomical structure development | 0.0153030598693199 |
| GO:0045859 | regulation of protein kinase activity | 0.0153030598693199 |
| GO:0065009 | regulation of a molecular function | 0.0153030598693199 |
| GO:0043549 | regulation of kinase activity | 0.0153030598693199 |
| GO:0006351 | transcription, DNA-dependent | 0.0153030598693199 |
| GO:0051338 | regulation of transferase activity | 0.0153030598693199 |
| GO:0008236 | serine-type peptidase activity | 0.0153030598693199 |
| GO:0007243 | protein kinase cascade | 0.0153030598693199 |
| GO:0017171 | serine hydrolase activity | 0.0153030598693199 |
| GO:0032774 | RNA biosynthetic process | 0.0153030598693199 |
| GO:0042113 | B cell activation | 0.0153030598693199 |
| GO:0044459 | plasma membrane part | 0.0169373556327751 |
| GO:0065007 | biological regulation | 0.01880045159054 |
| GO:0003677 | DNA binding | 0.0189931796699053 |
| GO:0006350 | transcription | 0.0217531781152329 |
| GO:0043229 | intracellular organelle | 0.0217531781152329 |
| GO:0043226 | organelle | 0.0217531781152329 |
| GO:0051059 | NF-kappaB binding | 0.0217531781152329 |
| GO:0000188 | inactivation of MAPK activity | 0.0217531781152329 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0220307576354492 |
| GO:0048523 | negative regulation of cellular process | 0.0222145898774114 |
| GO:0044425 | membrane part | 0.0222145898774114 |
| GO:0008134 | transcription factor binding | 0.0230828957669353 |
| GO:0030166 | proteoglycan biosynthetic process | 0.0243284837612225 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.024651213513139 |
| GO:0050790 | regulation of catalytic activity | 0.0248297243648196 |
| GO:0005634 | nucleus | 0.0250551574024361 |
| GO:0002376 | immune system process | 0.0250551574024361 |
| GO:0048731 | system development | 0.0250551574024361 |
| GO:0048519 | negative regulation of biological process | 0.0251662602808191 |
| GO:0045449 | regulation of transcription | 0.0268894621412778 |
| GO:0044424 | intracellular part | 0.0275993945202318 |
| GO:0005856 | cytoskeleton | 0.0275993945202318 |
| GO:0042127 | regulation of cell proliferation | 0.0283218012972411 |
| GO:0043407 | negative regulation of MAP kinase activity | 0.0283218012972411 |
| GO:0002521 | leukocyte differentiation | 0.0283218012972411 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0283218012972411 |
| GO:0043227 | membrane-bound organelle | 0.0283218012972411 |
| GO:0030674 | protein binding, bridging | 0.0283218012972411 |
| GO:0043405 | regulation of MAP kinase activity | 0.0296890120911624 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0297000382258562 |
| GO:0006584 | catecholamine metabolic process | 0.0305816502651164 |
| GO:0018958 | phenol metabolic process | 0.03250449324834 |
| GO:0005157 | macrophage colony stimulating factor receptor binding | 0.0334989599277837 |
| GO:0005020 | stem cell factor receptor activity | 0.0334989599277837 |
| GO:0004398 | histidine decarboxylase activity | 0.0334989599277837 |
| GO:0045746 | negative regulation of Notch signaling pathway | 0.0334989599277837 |
| GO:0006029 | proteoglycan metabolic process | 0.034543671757502 |
| GO:0030183 | B cell differentiation | 0.034543671757502 |
| GO:0009968 | negative regulation of signal transduction | 0.0355357073999626 |
| GO:0046983 | protein dimerization activity | 0.0407228993601328 |
| GO:0010468 | regulation of gene expression | 0.0418766635113604 |
| GO:0019222 | regulation of metabolic process | 0.049941600173736 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic stem cell | 1.09e-33 | 172 |
| angioblastic mesenchymal cell | 1.09e-33 | 172 |
| hematopoietic cell | 2.65e-31 | 182 |
| hematopoietic oligopotent progenitor cell | 3.56e-31 | 165 |
| hematopoietic multipotent progenitor cell | 3.56e-31 | 165 |
| leukocyte | 5.36e-30 | 140 |
| myeloid cell | 2.30e-28 | 112 |
| common myeloid progenitor | 2.30e-28 | 112 |
| myeloid leukocyte | 1.12e-24 | 76 |
| hematopoietic lineage restricted progenitor cell | 4.65e-24 | 124 |
| CD14-positive, CD16-negative classical monocyte | 1.78e-22 | 42 |
| granulocyte monocyte progenitor cell | 5.80e-22 | 71 |
| classical monocyte | 1.79e-21 | 45 |
| myeloid lineage restricted progenitor cell | 4.32e-21 | 70 |
| nongranular leukocyte | 8.21e-21 | 119 |
| macrophage dendritic cell progenitor | 1.51e-18 | 65 |
| monopoietic cell | 2.01e-17 | 63 |
| monocyte | 2.01e-17 | 63 |
| monoblast | 2.01e-17 | 63 |
| promonocyte | 2.01e-17 | 63 |
| Ontology term | p-value | n |
|---|---|---|
| adult organism | 6.30e-26 | 115 |
| hematopoietic system | 8.79e-25 | 102 |
| blood island | 8.79e-25 | 102 |
| hemolymphoid system | 7.26e-22 | 112 |
| bone marrow | 2.40e-18 | 80 |
| bone element | 6.14e-16 | 86 |
| immune system | 1.17e-13 | 115 |
| skeletal element | 2.45e-10 | 101 |
| skeletal system | 2.45e-10 | 101 |
| blood | 9.54e-07 | 15 |
| haemolymphatic fluid | 9.54e-07 | 15 |
| organism substance | 9.54e-07 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.
