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Coexpression cluster:C3743: Difference between revisions

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|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.027935202646963!CTCFL#140690;3:19.7464743589744:0.000129837200555116:0.00171668152788654!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325220583960964!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322058135462694!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0320501110189384!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128014779574606!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.0066393505969015!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0276590976537911!SMARCB1#6598;3:18.2527157811574:0.00016439776067989:0.0020297361068267!SMC3#9126;3:15.0449328449328:0.000293582542037187:0.00308962788269062!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0246348520560505!TCF7L2#6934;3:10.7701765631373:0.000800318129839838:0.00613463670916278!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0140112628381328
|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.027935202646963!CTCFL#140690;3:19.7464743589744:0.000129837200555116:0.00171668152788654!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325220583960964!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322058135462694!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0320501110189384!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128014779574606!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.0066393505969015!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0276590976537911!SMARCB1#6598;3:18.2527157811574:0.00016439776067989:0.0020297361068267!SMC3#9126;3:15.0449328449328:0.000293582542037187:0.00308962788269062!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0246348520560505!TCF7L2#6934;3:10.7701765631373:0.000800318129839838:0.00613463670916278!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0140112628381328
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}}
}}

Revision as of 16:19, 26 November 2012


Full id: C3743_Smooth_Fibroblast_clear_basal_normal_sacrococcigeal_Preadipocyte



Phase1 CAGE Peaks

Hg19::chr18:9334755..9334778,+p2@TWSG1
Hg19::chr18:9334786..9334844,+p1@TWSG1
Hg19::chr18:9334857..9334871,+p3@TWSG1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multilaminar epithelium8.72e-1483
somite1.83e-1371
presomitic mesoderm1.83e-1371
presumptive segmental plate1.83e-1371
dermomyotome1.83e-1371
trunk paraxial mesoderm1.83e-1371
dense mesenchyme tissue1.91e-1373
unilaminar epithelium2.10e-13148
paraxial mesoderm4.49e-1372
presumptive paraxial mesoderm4.49e-1372
mesenchyme5.24e-13160
entire embryonic mesenchyme5.24e-13160
organism subdivision1.45e-12264
surface structure3.95e-1299
skeletal muscle tissue8.70e-1262
striated muscle tissue8.70e-1262
myotome8.70e-1262
muscle tissue9.65e-1264
musculature9.65e-1264
musculature of body9.65e-1264
epithelial vesicle1.44e-1178
trunk mesenchyme1.81e-11122
multi-cellular organism7.66e-11656
vasculature1.79e-1078
vascular system1.79e-1078
trunk3.12e-10199
splanchnic layer of lateral plate mesoderm2.51e-0983
integument4.00e-0946
integumental system4.00e-0946
artery1.25e-0842
arterial blood vessel1.25e-0842
arterial system1.25e-0842
epithelial tube open at both ends3.21e-0859
blood vessel3.21e-0859
blood vasculature3.21e-0859
vascular cord3.21e-0859
systemic artery4.89e-0833
systemic arterial system4.89e-0833
skin of body5.95e-0841
anatomical system6.10e-08624
vessel8.75e-0868
anatomical group8.76e-08625
multi-tissue structure2.44e-07342
cardiovascular system7.91e-07109


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.027935202646963
CTCFL#140690319.74647435897440.0001298372005551160.00171668152788654
E2F1#186934.907389214879320.008460985347239390.0325220583960964
E2F6#187635.017155731697390.00791769806886330.0322058135462694
EGR1#195834.988179094810140.008056488137383440.0320501110189384
IRF1#365937.63716375356390.002244692747297240.0128014779574606
RAD21#5885310.35503389545630.0009004912073565420.0066393505969015
SIN3A#2594235.408884726815140.006318961977991520.0276590976537911
SMARCB1#6598318.25271578115740.000164397760679890.0020297361068267
SMC3#9126315.04493284493280.0002935825420371870.00308962788269062
SP1#666735.69838137814090.005403962701712170.0246348520560505
TCF7L2#6934310.77017656313730.0008003181298398380.00613463670916278
ZBTB7A#5134137.35190930787590.002516255860282270.0140112628381328



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.