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Coexpression cluster:C1597

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Full id: C1597_tongue_esophagus_tonsil_salivary_Urothelial_uterus_Sebocyte



Phase1 CAGE Peaks

Hg19::chr10:88780049..88780051,+p1@FAM25A
p1@FAM25B
p1@FAM25C
p1@FAM25G
Hg19::chr18:28682042..28682065,-p1@DSC2
Hg19::chr1:152881014..152881031,+p1@IVL
Hg19::chr1:152956549..152956566,+p1@SPRR1A
Hg19::chr5:175837706..175837718,-p@chr5:175837706..175837718
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001533cornified envelope4.97273171415869e-05
GO:0018149peptide cross-linking4.97273171415869e-05
GO:0030216keratinocyte differentiation4.97273171415869e-05
GO:0031424keratinization6.02634697148427e-05
GO:0009913epidermal cell differentiation8.0631044571239e-05
GO:0048730epidermis morphogenesis8.48377189719717e-05
GO:0048729tissue morphogenesis0.000125121378813316
GO:0030674protein binding, bridging0.000175335735425548
GO:0008544epidermis development0.000343951134968523
GO:0007398ectoderm development0.000362182563126683
GO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine0.000896639637616591
GO:0018262isopeptide cross-linking0.000896639637616591
GO:0018199peptidyl-glutamine modification0.000896639637616591
GO:0009888tissue development0.00112951219199769
GO:0010224response to UV-B0.00233098856281588
GO:0018205peptidyl-lysine modification0.00327766317991456
GO:0009653anatomical structure morphogenesis0.0106752079742699
GO:0009411response to UV0.0106752079742699
GO:0048513organ development0.0114829820279232
GO:0005856cytoskeleton0.0167343191641621
GO:0048731system development0.020371068107999
GO:0009416response to light stimulus0.0214083531263655
GO:0048869cellular developmental process0.0225762523406492
GO:0030154cell differentiation0.0225762523406492
GO:0009314response to radiation0.0234772039668322
GO:0048856anatomical structure development0.0254717113136489
GO:0018193peptidyl-amino acid modification0.0260273918288617
GO:0043687post-translational protein modification0.0292534242733274
GO:0007275multicellular organismal development0.0298465535499906
GO:0009628response to abiotic stimulus0.0319013040474445
GO:0005911intercellular junction0.0323614306114214
GO:0006464protein modification process0.0361448543059518
GO:0007156homophilic cell adhesion0.0361448543059518
GO:0005515protein binding0.0361448543059518
GO:0043412biopolymer modification0.0366866041825411
GO:0043232intracellular non-membrane-bound organelle0.0372597586169451
GO:0043228non-membrane-bound organelle0.0372597586169451
GO:0032502developmental process0.0472438379781197



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
endo-epithelial cell1.14e-1243
epithelial cell1.35e-12254
endodermal cell1.52e-1059
Disease
Ontology termp-valuen
carcinoma6.78e-07106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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