Coexpression cluster:C2064

Full id: C2064_Intestinal_choriocarcinoma_breast_Prostate_pancreatic_colon_MCF7

Phase1 CAGE Peaks

Hg19::chr10:5535609..5535633,-	p@chr10:5535609..5535633 -
Hg19::chr10:5535635..5535648,-	p@chr10:5535635..5535648 -
Hg19::chr10:5535762..5535773,-	p@chr10:5535762..5535773 -
Hg19::chr6:3789350..3789355,-	p@chr6:3789350..3789355 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
chorionic membrane mesenchymal stem cell	8.57e-16	3
germ line cell	6.79e-12	7
germ cell	6.79e-12	7
endodermal cell	1.13e-09	59
metabolising cell	9.95e-07	12
endopolyploid cell	9.95e-07	12
parenchymal cell	9.95e-07	12
polyploid cell	9.95e-07	12
hepatocyte	9.95e-07	12

Uber Anatomy

Ontology term	p-value	n
acellular anatomical structure	8.57e-16	3
egg chorion	8.57e-16	3
chorion	7.81e-12	7
endo-epithelium	9.23e-12	82
gut epithelium	5.69e-09	54
extraembryonic membrane	8.90e-09	14
membranous layer	8.90e-09	14
epithelium of foregut-midgut junction	1.08e-08	25
anatomical boundary	1.08e-08	25
hepatobiliary system	1.08e-08	25
foregut-midgut junction	1.08e-08	25
septum transversum	1.08e-08	25
epithelial sac	1.18e-08	25
breast	1.70e-08	10
sac	2.74e-08	26
chest	1.00e-07	11
hepatic diverticulum	1.97e-07	22
liver primordium	1.97e-07	22
epithelial bud	2.96e-07	37
mixed endoderm/mesoderm-derived structure	3.57e-07	130
subdivision of digestive tract	3.66e-07	129
endodermal part of digestive tract	3.66e-07	129
digestive system	4.29e-07	155
digestive tract	4.29e-07	155
primitive gut	4.29e-07	155
digestive tract diverticulum	4.39e-07	23
endoderm-derived structure	4.45e-07	169
endoderm	4.45e-07	169
presumptive endoderm	4.45e-07	169

Disease

Ontology term	p-value	n
thoracic cancer	4.09e-21	4
breast cancer	4.09e-21	4
disease of anatomical entity	1.14e-15	39
carcinoma	1.30e-15	106
cell type cancer	1.66e-14	143
cancer	2.25e-08	235
disease of cellular proliferation	4.38e-08	239
adenocarcinoma	9.03e-07	25

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	4	7.97114762582482	0.000247638578809083	0.00267429692195655
EP300#2033	4	6.7739417262232	0.000474845982144264	0.0043338669517753
ESR1#2099	3	23.0764524721159	0.000133910524496857	0.00175697000853357
FOXA1#3169	4	11.0814197493855	6.62943068949433e-05	0.00106896883090952
FOXA2#3170	4	24.6304637526652	2.71504128667089e-06	9.41421636582406e-05
GATA3#2625	3	20.4273872679045	0.000192441557625832	0.00231842240591582
HDAC2#3066	4	13.4156202366263	3.0859005065161e-05	0.000625559710791993
HNF4G#3174	4	28.7534225264468	1.46167379934821e-06	5.65601148314664e-05
SP1#6667	4	5.6983813781409	0.000948260606533398	0.00682908491833827
TCF7L2#6934	4	10.7701765631373	7.42969445082454e-05	0.0011516026398778

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.